Treatment of keratoacanthomas with intralesional methotrexate

Intralesional methotrexate treatment for keratoacanthoma tumors: A retrospective study and review of the literature

“…However, surgical intervention may lead to substantial defects with significant functional or cosmetic morbidity, depending on size and location. 15,27 In addition, patients with comorbid conditions may be poor surgical candidates. In these circumstances, intralesional MTX may offer the advantage of being relatively noninvasive, less expensive, quickly administered, and tissue sparing.…”

“…1,2 Several treatment options exist, including standard excision, 1,2 Mohs excision, 3,4 systemic retinoids, 5 radiotherapy, 6,7 curettage and electrodessication, [8][9][10] intralesional 5-fluorouracil, [11][12][13][14] and intralesional methotrexate (MTX). [15][16][17][18][19][20][21][22] Less established methods of treatment in the recent literature include intralesional interferon alfa-2b 23 and topical imiquimod. 24 Previous case reports have demonstrated intralesional MTX to be an effective, minimally invasive treatment for KA tumors, however, overall tumor cure rates and adverse events have not been systematically examined.…”

“…24 Previous case reports have demonstrated intralesional MTX to be an effective, minimally invasive treatment for KA tumors, however, overall tumor cure rates and adverse events have not been systematically examined. [15][16][17][18][19][20][21] Our purpose was to collect data from our institution, providing the largest published series of KA treated with intralesional MTX. In addition, we performed a review of the literature on treatment of KA with intralesional MTX and pooled these data with our own.…”

Plattenepithelkarzinome des Gesichtes mit neurotropem Wachstum

“…Dennoch wird die Dignität neurotroper KA unterschiedlich beurteilt.In einigen Arbeiten wird das KA trotz neurotropem Wachstums als benigne eingestuft [13,22,28,33,47]. Wichtig erscheint bei neurotropem Wachstum eine komplette Exzision oder intraläsionale MethotrexatInjektion [63], um ein weiteres Tiefenwachstum zu unterbinden.…”

Management of Keratoacanthoma

“…Systemic retinoids [21] may be useful in some situations and could be used in multiple lesions. Intralesional therapies such as intra-lesional methotrexate (IL-MTX) [22][23][24][25][26][27][28]29••] and 5-fluorouracil [22,30] have been used for solitary lesions with various success rates and side effects. In our center we examined retrospectively 46 patients who were treated with IL-MTX [29••].…”