Treatment of Knee Osteoarthritis With Autologous Mesenchymal Stem Cells

Orozco, Lluís; Munar, Anna; Soler, Robert; Alberca, Mercedes; Soler, Francesc; Huguet, Marina; Sentís, Joan; Sánchez, Abraham; García‐Sancho, Javier

doi:10.1097/tp.0b013e318291a2da

Cited by 414 publications

(267 citation statements)

References 47 publications

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“…34,35 Some studies include case series and clinical trials with BM mesenchymal cells; some of them administered the cells by means of surgical intervention 13,[36][37][38] and others with intra-articular injection. 12,[39][40][41][42] We evaluated our results by means of VAS and WOMAC scales, since these have been used in many other knee OA studies, 40 in order to determine knee function and pain, and found that there was an improvement from the first week in the BM-SC group. In this setting it is possible that SCs have an antiinflammatory effect, which could explain the short-term clinical improvement.…”

Section: Discussionmentioning

confidence: 99%

The effect of intra‐articular injection of autologous bone marrow stem cells on pain and knee function in patients with osteoarthritis

et al. 2017

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Aim: Management of osteoarthritis (OA) is basically symptomatic. Recently, stem cells (SC) have been used in the search for an optimum treatment. We decided to conduct a controlled clinical trial to determine if a single intra-articular injection of in vivo stimulated bone marrow SC could lead to an improvement in pain management and quality of life in patients with knee OA.Method: This was a prospective, open-label, phase I/II clinical trial to assess the safety and efficacy of a single intra-articular injection of autologous stimulated bone marrow stem cells (BM-SC) in patients with knee OA. Individuals of both genders older than 30 years with confirmed diagnosis of OA who signed informed consent were included in two groups: SC group received in vivo BM stimulation with subcutaneous administration of granulocyte colony stimulating factor (G-CSF). SC were obtained by BM aspiration and administered in a single intra-articular injection. The control group received exclusively oral acetaminophen. Visual analogue scale and Western Ontario and McMaster Universities Osteoarthritis Index scores were performed at 1 week, 1 month and 6 months in both groups. This trial was registered in ClinialTrials.gov NCT01485198.Results: A total of 61 patients were included. Socio-demographic characteristics, OA grades and initial scores were similar in both groups. The BM-SC group showed significant improvement in knee pain and quality of life during the 6-month follow-up. Conclusion:The study demonstrates feasibility and supports efficacy of a completely ambulatory procedure in treatment of knee OA.

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Section: Discussionmentioning

confidence: 99%

The effect of intra‐articular injection of autologous bone marrow stem cells on pain and knee function in patients with osteoarthritis

et al. 2017

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“…Magnetic resonance imaging (MRI) scans performed one year after the surgical intervention showed significantly better Magnetic Resonance Observation of Cartilage Repair Tissue (MOCART) scores for the cell-recipient group than the microfracture alone group (28 patients) [76]. In a pilot study of 12 OA patients with intra-articular injection of 40 million autologous expanded BM-MSCs, the patients showed a large improvement in algofunctional indices by one year, and MRI scanning exhibited a 27% decrease in poor cartilage areas with improvement of cartilage quality in 11 of the 12 patients [77]. Most recently, two clinical trials have attracted a lot of interest.…”

Section: Msc Therapy For Oamentioning

confidence: 96%

Treatment of osteoarthritis with mesenchymal stem cells

Wang

Cao

2014

Sci. China Life Sci.

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Osteoarthritis (OA) is one of the most prevalent joint diseases with prominent symptoms affecting the daily life of millions of middle aged and elderly people. Despite this, there are no successful medical interventions that can prevent the progressive destruction of OA joints. The onset of pathological changes in OA is associated with deviant activity of mesenchymal stem cells (MSCs), the multipotent precursors of connective tissue cells that reside in joints. Current therapies for OA have resulted in poor clinical outcomes without repairing the damaged cartilage. Intra-articular delivery of culture-expanded MSCs has opened new avenues of OA treatment. Pre-clinical and clinical trials demonstrated the feasibility, safety, and efficacy of MSC therapy. The Wnt/β-catenin, bone morphogenetic protein 2, Indian hedgehog, and Mitogen-activated protein kinase signaling pathways have been demonstrated to be involved in OA and the mechanism of action of MSC therapies. osteoarthritis, mesenchymal stem cells, intra-articular delivery Citation:Wang W, Cao W. Treatment of osteoarthritis with mesenchymal stem cells.

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“…26,27 Intra-articular injection of autologous MSCs in to the knee joints of patients with OA has been well tolerated and a significant reduction in pain has been observed, with paracrine anti-inflammatory activity of MSCs postulated to contribute to this outcome. [28][29][30] Furthermore, treatment of patients undergoing partial meniscectomy surgery with an intra-articular injection of allogeneic MSCs has resulted in meniscal regeneration as well as a significant reduction in pain. 31 To achieve successful regeneration with tissue engineering approaches in an osteoarthritic joint, an in-depth understanding is required of how OA-associated inflammation impacts chondrocyte and progenitor cell behavior.…”

Section: -24mentioning

confidence: 99%

Immune Modulation to Improve Tissue Engineering Outcomes for Cartilage Repair in the Osteoarthritic Joint

Fahy

Farrell

Ritter

et al. 2015

Tissue Engineering Part B: Reviews

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Treatment of Knee Osteoarthritis With Autologous Mesenchymal Stem Cells

Abstract: MSC therapy may be a valid alternative treatment for chronic knee osteoarthritis. The intervention is simple, does not require hospitalization or surgery, provides pain relief, and significantly improves cartilage quality.

Cited by 414 publications

References 47 publications

The effect of intra‐articular injection of autologous bone marrow stem cells on pain and knee function in patients with osteoarthritis

The effect of intra‐articular injection of autologous bone marrow stem cells on pain and knee function in patients with osteoarthritis

Treatment of osteoarthritis with mesenchymal stem cells

Immune Modulation to Improve Tissue Engineering Outcomes for Cartilage Repair in the Osteoarthritic Joint

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