Treatment of Laryngeal Sarcoidosis with Intralesional Steroid Injection

Krespi, Yosef P.; Husain, S. Adil; Mitrani, Moises; Meltzer, Charles

doi:10.1177/000348948709600622

Cited by 64 publications

(41 citation statements)

References 10 publications

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“…In the adult age group, LTS without evident etiology or LTS presenting with atypical endoscopic features should always be biopsied to identify possible rare conditions such as Wegener's granulomatosis [35][36][37], relapsing polychondritis [38,39], other autoimmune disorders [40], tuberculosis [41][42][43], sarcoidosis [44,45] or idiopathic SGS [46][47][48] and amyloidosis [49], to name just a few among the most frequently described in the literature.…”

Section: Bronchoesophagoscopymentioning

confidence: 99%

Preoperative assessment and classification of benign laryngotracheal stenosis: a consensus paper of the European Laryngological Society

Monnier

Dikkers

Eckel

et al. 2015

Eur Arch Otorhinolaryngol

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Adult and pediatric laryngotracheal stenoses (LTS) comprise a wide array of various conditions that require precise preoperative assessment and classification to improve comparison of different therapeutic modalities in a matched series of patients. This consensus paper of the European Laryngological Society proposes a five-step endoscopic airway assessment and a standardized reporting system to better differentiate fresh, incipient from mature, cicatricial LTSs, simple one-level from complex multilevel LTSs and finally ''healthy'' from ''severely morbid'' patients. The proposed scoring system, which integrates all of these parameters, may be used to help define different groups of LTS patients, choose the best treatment modality for each individual patient and assess distinct post-treatment outcomes accordingly.

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Section: Bronchoesophagoscopymentioning

confidence: 99%

Preoperative assessment and classification of benign laryngotracheal stenosis: a consensus paper of the European Laryngological Society

Monnier

Dikkers

Eckel

et al. 2015

Eur Arch Otorhinolaryngol

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“…Intralesional steroid injection in combination with mucosa-sparing laser surgery has recently been described with good results [19]. Steroid can be administered either by inhalation [20] or intralesionally [5,15,21]. Another combined local approach is laser surgery and application of mitomycin-C [22].…”

Section: Introductionmentioning

confidence: 99%

Clinically isolated laryngeal sarcoidosis

Plaschke¹,

Owen²,

Rasmussen³

2010

Eur Arch Otorhinolaryngol

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Laryngeal sarcoidosis is rare (0.5% of patients with sarcoidosis), the pathogenesis is unknown and the optimal treatment remains a matter of debate. We undertook this study to elucidate possible pathogenic factors in clinically isolated laryngeal sarcoidosis and to describe results of supraglottoplastic surgery. From 1995 to 2009, we identified six patients with histologically proven sarcoidosis of the larynx treated at Rigshospitalet. All patients were subjected to a panel of blood tests and MR scan of the head and neck. All patients had dyspnoea at admission, and five were subjected to a combination of CO(2)-laser excision of supraglottic tissue and closure of the incision with sutures. All serological tests were negative or normal, including angiotensin 1 converting enzyme. The clinical expression was uniform with pale, smooth swellings of the supraglottic structures. Surgery proved successful to maintain normal breathing. None of the many parameters examined--some previously having been found to be abnormal in sarcoidosis--were abnormal in the present cohort. We are therefore unable to elucidate the pathogenesis. The combined surgical approach re-established normal airway function for all five patients and complete remission without further swellings was seen in two patients.

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“…The primary symptoms of laryngeal sarcoidosis are dysphonia and dyspnea [2,10,13], and the symptoms are caused by airway obstruction. Thus, in cases that do not resolve spontaneously, treatment for laryngeal sarcoidosis should be performed to remove obstruction in the airway.…”

Section: Discussionmentioning

confidence: 99%

“…Sarcoidosis is a chronic disease characterized by noncaseating granulomatous inflammation, usually in multiple organs, and commonly in the lungs and lymph nodes as well as in the spleen, liver, eyes, skin, bones, and nervous system [7,10]. Laryngeal sarcoidosis is estimated to occur in 1-6% of patients who experience the generalized condition [6,9,12].…”

Section: Introductionmentioning

confidence: 99%

Polypoid type of laryngeal sarcoidosis - case report and review of the literature

Sakamoto

Ishizawa

Kitahara³

2000

European Archives of Oto-Rhino-Laryngology

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A 45-year-old mentally retarded woman was discovered to produce a stridor upon inhalation. Fiberoptic laryngoscopic study revealed a smooth-surfaced, wide, and pedunculated tumor on the right arytenoid and the right aryepiglottic fold. Histopathological study revealed that the tumor was characterized by granulomatous inflammation. The condition was diagnosed as laryngeal sarcoidosis. The tumor was resected surgically. Surgical resection of the tumor and injection of corticosteroid should be performed for polypoid-type laryngeal sarcoidosis. The case is discussed in detail, along with a review of the literature pertaining to sarcoidosis of the larynx.

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Treatment of Laryngeal Sarcoidosis with Intralesional Steroid Injection

Cited by 64 publications

References 10 publications

Preoperative assessment and classification of benign laryngotracheal stenosis: a consensus paper of the European Laryngological Society

Preoperative assessment and classification of benign laryngotracheal stenosis: a consensus paper of the European Laryngological Society

Clinically isolated laryngeal sarcoidosis

Polypoid type of laryngeal sarcoidosis - case report and review of the literature

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