1993
DOI: 10.1093/schbul/19.4.817
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Treatment of Late-life Schizophrenia With Neuroleptics

Abstract: There is a death of literature on the effects of neuroleptics in older schizophrenia patients. In this article, we review the available literature and present findings from our own studies. Neuroleptics are effective in the treatment of late-life schizophrenia, although older patients generally need lower dosages than younger subjects. Neuroleptics, however, carry a relatively high risk of side effects such as tardive dyskinesia (TD) in middle-aged and elderly patients. By the end of 1 year of a prospective lo… Show more

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Cited by 91 publications
(29 citation statements)
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“…It has been suggested that increased likelihood of TD emergence in older adults with schizophrenia may be due to interaction between neurodevelopmental and neurodegenerative processes with advancing age and medication response (Waddington and Youssef, 1996). Reported risk factors for increased risk of TD in the elderly include prior exposure to antipsychotic medications, history of alcohol abuse, pre-existing movement disorder, and use of antipsychotic medication at daily doses above 150 mg/day of chlorpromazine (Jeste et al, 1993). Individuals in the study reported here have a number of these risk factors.…”
Section: Discussionmentioning
confidence: 99%
“…It has been suggested that increased likelihood of TD emergence in older adults with schizophrenia may be due to interaction between neurodevelopmental and neurodegenerative processes with advancing age and medication response (Waddington and Youssef, 1996). Reported risk factors for increased risk of TD in the elderly include prior exposure to antipsychotic medications, history of alcohol abuse, pre-existing movement disorder, and use of antipsychotic medication at daily doses above 150 mg/day of chlorpromazine (Jeste et al, 1993). Individuals in the study reported here have a number of these risk factors.…”
Section: Discussionmentioning
confidence: 99%
“…2 Nevertheless, sensitivity to antipsychotic medication has been identified in a number of treatment studies of late-onset psychosis, and necessitates a cautious approach by the clinician in considering this treatment option. [37][38][39] Extrapyramidal and anticholinergic sideeffects, and drug interactions, are more common than in younger patients, resulting in significant morbidity. In addition, the risk of tardive dykinesia is markedly greater in elderly patients taking antipsychotic medication.…”
Section: Treatment and Longitudinal Coursementioning
confidence: 99%
“…The collection and analysis of such data are imperative, if useful criteria for their longitudinal identification are to be developed and optimal treatment duration for different types of BPSD can be determined. The identification of specific treatment durations for specific symptoms is important because the use of psychotropic medication is related to increasing side effects with advancing age [10].…”
Section: Introductionmentioning
confidence: 99%