Treatment of leiomyomata uteri with leuprolide acetate depot: A double‐blind, placebo‐controlled, multicenter study

Aj, Friedman; Hoffman, D I; Comite, Florence; Browneller, RW; Miller, J. D.

doi:10.1016/0020-7292(92)90069-u

Cited by 79 publications

(94 citation statements)

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“…It has been reported that the uterine volume reduced following subcutaneous injection of 3.75 mg of GnRHa. The uterine cavity and glandular lumen volumes of mice narrowed and the uterine wall became thinner significantly, particularly the uterine endometrium (Friedman et al 1991;Shunichiro et al 2006). However, there was no significant difference between the efficacies of different doses and durations of GnRHa (Jasonni et al 2001).…”

Section: Discussionmentioning

confidence: 99%

“…The uterine volume was reduced by 36% at 12 weeks and 45% at 24 weeks following subcutaneous injection of 3.75 mg of GnRHa, once every 4 weeks, for 24 weeks (Friedman et al 1991). However, there was no significant difference between the degrees of uterine volume reduction following administration of 3.75 mg leuprolide acetate (Jasonni et al 2001).…”

Section: Introductionmentioning

confidence: 88%

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GnRHa active immunity regulates expression of LHR protein and development of uteri in ewes

Wei¹,

Ouyang²,

Guli³

et al. 2013

Journal of Applied Animal Research

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To investigate the LHR protein expressions in the ovine uteri and LH secretion, and to determine whether the alarelin active immunity affects the uterine development in ewes. Twenty-eight ewes (five to six months) were assigned to four experimental groups. Animals in EG-1, EG-2 and EG-3 were subcutaneously injected with 200, 300 and 400 mg alarelin antigens (day 0 and 14), respectively. Animals in the CG were injected with 2.0 mL solvent (day 0 and 14). Uterine horns were dissected aseptically on day 70. The serum LH concentrations were measured using ELISA. Tissue slices were observed and photographed under optical and electron microscopes. The images were measured using Images software. The results showed that the expressions of LHR protein in EGs increased. The level of LHR protein in EG-3 was higher than that in CG (P B0.05). Serum LH concentrations in EGs were lower than that in CG from day 21 to day 45 (P B0.05). Uterine weights in EG-1, EG-2 and EG-3 reduced by 4.66%, 10.20% and 16.63% (PB0.05), respectively. Uterine wall thickness (UWT) in EG-1, EG-2 and EG-3 reduced by 1.41%, 5.84% and 8.75% (P B0.05), respectively. The endometrial epithelium thickness (EET) in EG-1, EG-2 and EG-3 decreased too (P B0.05). The uterine wall shrank obviously and the glandular cavity reduced. The microvilli shortened. The mitochondria and mitochondrial crista decreased. Summarily, alarelin immunity could promote LHR protein expression in the uteri, and decreased serum LH concentrations, including decreased EET, UWT and uterine weights, could affect the uterine microstructure and ultrastructure, resulting in the inhibition of uterine development dose-dependently.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 88%

GnRHa active immunity regulates expression of LHR protein and development of uteri in ewes

Wei¹,

Ouyang²,

Guli³

et al. 2013

Journal of Applied Animal Research

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show abstract

“…For example, the uterine volume was reduced by 36% at 12 weeks and 45% at 24 weeks after subcutaneous injection of 3.75 mg of GnRH (Friedman et al, 1991). Moreover, the uterine weights in mice treated with GnRH agonist immunization decreased by 34.43%-55.74% when compared with controls, and uterine wall thickness was reduced by 8.64%-14.03% (Wei et al, 2011).…”

Section: Discussionmentioning

confidence: 97%

“…Administration of progesterone, progesterone analogues, and prostaglandins modify the luteal phase of the cycle (Abecia et al, 2012). Moreover, it also induces uterine contractions due to ecbolic properties, and it has an ovulatory effect, which is due to the immediate rise in gonadotropins (Friedman et al, 1991). Cloprostenol (CLO) is a potent prostaglandin (PGF) F2α analogue that influences the estrus of animals by lysing appearance of the corpus lutein (Crawford et al, 2009).…”

Section: Introductionmentioning

confidence: 99%

Cloprostenol and pregnant mare serum gonadotropin promote estrus synchronization, uterine development, and follicle-stimulating hormone receptor expression in mice

Wei¹,

Gong²,

An³

et al. 2015

Genet. Mol. Res.

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ABSTRACT. This study investigated the effects of pregnant mare serum gonadotropin (PMSG) and cloprostenol (CLO) on estrus induction and synchronization, uterine development, and follicle-stimulating hormone receptor (FSHR) expression in mice. A total of 105 Kunming pre-puberty mice were divided into seven subgroups. Three PMSG subgroups were injected intraperitoneally with 10, 20, and 40 IU PMSG twice (on days 0 and 4), and three CLO subgroups were injected intraperitoneally with 10, 15, and 20 μg cloprostenol acetate twice (on days 0 and 4). The results showed that 93.33 and 66.67% of synchronized mice displayed estrus within 18.68-37.59 h following CLO and PMSG exposure, respectively. Estrus numbers, estrus onset time, and estrus rates in CLO and PMSG groups were greater than in control groups (CG) (P < 0.05). Uterine weights of the PMSG group were higher than 7185 Uterine FHSR expression and development ©FUNPEC-RP www.funpecrp.com.br Genetics and Molecular Research 14 (2): 7184-7195 (2015) that of CLO and CG groups, and the uterine horn longitudinal diameters in experimental mice were greater than CG. Expression levels of FSHR proteins in CLO and PMSG groups increased slightly when compared to CG. In conclusion, CLO and PMSG administration did not clearly affect the expression of uterine FSHR proteins in mice. Moreover, PMSG and CLO treatments synchronized estrus and enhanced the uterine development of mice. The efficacy of CLO on estrus synchronization was greater than PMSG, and the effects of PMSG on uterine development were stronger than CLO. These results have important significance regarding the modulation of animal reproductive functions.

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“…[5] No mutations have been found in human uterine leiomyomas (n=6). CONCLUSIONS: hRPS19 overexpression migh be a universal signal in rapid cell growth tissues.…”

Section: Introductionmentioning

confidence: 99%

Identification of differentially expressed genes in human uterine leiomyomas using differential display

Sun

et al. 2002

Cell Res

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In searching of differentially expressed genes in human uterine leiomyomas, differential display was used with twelve pairs of primers to compare human uterine leiomyomas with matched myometrium. False positives were eliminated by reverse Northern analysis. Positives were confirmed by Northern blot analysis. RESULTS: [1] Four of 69 cDNA fragments (3 up-regulated named L1, L2 and L3 and 1 down-regulated named M1 in leiomyoma) were confirmed by Northern analysis.[2] Sequence comparison and Northern analysis proved that L1 is exactly the human ribosomal protein S19.[3] It was present ubiquitously in 13 tissues tested but in various levels and even in different size.[4] L1 was highly expressed in parotidean cystadenocarcinoma, pancreatic cancer and breast cancer examined. [5] No mutations have been found in human uterine leiomyomas (n=6). CONCLUSIONS: hRPS19 overexpression migh be a universal signal in rapid cell growth tissues.

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Treatment of leiomyomata uteri with leuprolide acetate depot: A double‐blind, placebo‐controlled, multicenter study

Cited by 79 publications

References 0 publications

GnRHa active immunity regulates expression of LHR protein and development of uteri in ewes

GnRHa active immunity regulates expression of LHR protein and development of uteri in ewes

Cloprostenol and pregnant mare serum gonadotropin promote estrus synchronization, uterine development, and follicle-stimulating hormone receptor expression in mice

Identification of differentially expressed genes in human uterine leiomyomas using differential display

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