1994
DOI: 10.1002/1097-0142(19941115)74:10<2749::aid-cncr2820741003>3.0.co;2-m
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Treatment of liver metastases from colorectal cancer with hepatic artery occlusion, intraportal 5-fluorouracil infusion, and oral allopurinol. A randomized clinical trial

Abstract: Background. Regional therapy for colorectal liver metastases aimed at prolonging survival has not been tested fully in a randomized trial with untreated control subjects. This study explored the efficacy of temporary hepatic artery occlusion followed by intraportal infusion of 5‐fluorouracil(5‐FU) and oral allopurinol as biochemical modulators in prolonging the survival of patients with nonresectable liver metastases and no extrahepatic cancer. Methods. Eighty‐four patients were considered for randomization, o… Show more

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Cited by 31 publications
(10 citation statements)
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“…Two trials included patients with other digestive tract tumours in addition to colorectal cancer. 9 10 One trial specified an upper age limit of 70 years,11 seven trials had an upper age limit of 75 years, 9 1217 and one trial was performed exclusively in patients aged 70 years or older 10…”
Section: Resultsmentioning
confidence: 99%
“…Two trials included patients with other digestive tract tumours in addition to colorectal cancer. 9 10 One trial specified an upper age limit of 70 years,11 seven trials had an upper age limit of 75 years, 9 1217 and one trial was performed exclusively in patients aged 70 years or older 10…”
Section: Resultsmentioning
confidence: 99%
“…No differences in survival were seen between the two groups. In the last trial, 60 patients with disease limited to the liver were randomised between temporary hepatic artery occlusion with intraportal chemotherapy or to a control group (67). Hepatic artery occlusion has not been found to in uence survival.…”
Section: In Uence On Sur×i×almentioning
confidence: 99%
“…5-Fluorouracil (5-FU) is one of the cytostatic agents that, as a single agent (but in combination with folinic acid), produces response rates averaging 20% (Skibber et al, 2000); irinotecan, raltitrexed and oxaliplatin have in some studies achieved similar response rates (Cunningham et al, 1995;Becouarn et al, 1998;Diaz-Rubio et al, 1998;Saltz et al, 2000). 5-Fluorouracil leads to a modest survival benefit when compared to approaches such as best supportive care (Nodic Gastrointestinal Tumor Adjuvant Therapy Group, 1992;Allen-Mersh et al, 1994;Hafstrom et al, 1994). Moreover, chemotherapy delays the occurrence or progression of symptoms by 6 months and improves symptoms without severe toxicity in 40% (Nordic Gastrointestinal Tumor Adjuvant Therapy Group, 1992;Glimelius, 1993;Allen-Mersh et al, 1994).…”
mentioning
confidence: 99%