Treatment of lung cancer via telomerase inhibition: Self-assembled nanoplexes versus polymeric nanoparticles as vectors for 2′-O-Methyl-RNA

Nafee, Noha; Schneider, Marc; Friebel, Kristin; Meng, Di; Schaefer, Ulrich F.; Mürdter, Thomas E.; Lehr, Claus‐Michael

doi:10.1016/j.ejpb.2011.11.019

Cited by 31 publications

(11 citation statements)

References 45 publications

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“…With the same concept, Davis developed a four-component formulation containing imidazole-modified CD polymer for si-RNA delivery [43]. However, the slower growth rate of Caco-2 cells relative to A549 cells as well as the mucoadhesive properties of chitosan and its effect on tight junctions interfered with particle uptake/transport in various cell lines such as Calu-3 and Caco-2 [41,44].…”

Section: Uptake Studiesmentioning

confidence: 97%

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Cyclodextrin-based star polymers as a versatile platform for nanochemotherapeutics: Enhanced entrapment and uptake of idarubicin

Nafee

Hirosue

Loretz

et al. 2015

Colloids and Surfaces B: Biointerfaces

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Section: Uptake Studiesmentioning

confidence: 97%

“…Many previous studies demonstrated the efficient role of chitosan in improving the cellular uptake of nanoparticles [41]. Recent researches proved the ability of chitosan-coating to reduce phagocytosis by macrophages of the mononuclear phagocytic system after intestinal uptake [42].…”

Section: Uptake Studiesmentioning

confidence: 99%

Cyclodextrin-based star polymers as a versatile platform for nanochemotherapeutics: Enhanced entrapment and uptake of idarubicin

Nafee

Hirosue

Loretz

et al. 2015

Colloids and Surfaces B: Biointerfaces

Self Cite

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“…During cytotoxicity assays, chitosan-coated triangular silver NPs were efficiently taken by the cancer cells and exhibited low cytotoxicity on normal embryonoic cells. Nafee and his groups in another work embellished chitosan-modified PLGA NPs with antisense oligonucleotide, 2′-O-Methyl-RNA (OMR-a potential telomerase inhibitor which prevents telomere shortening during cell proliferation in NSCLC tissues) and successfully transfected OMR to A549 cells and Calu-3 cells [27]. Often various polymer NPs are modified with chitosan for oral delivery of chemotherapeutic drugs and genes to deeply embedded lung cancer cells.…”

Section: Chitosan Nanoparticlesmentioning

confidence: 98%

Natural and Semisynthetic Nanoparticles in Lung Cancer Diagnosis and Therapy

Bandyopadhyay

Das

Yeasmin

2014

SpringerBriefs in Molecular Science

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Natural and semisynthetic nanoparticles have significantly attracted lung cancer therapy owing to their high biocompatibility and biodegradability. Most of them are suitable as carriers of drugs, genes, imaging probes, and various macromolecules. This chapter focuses on utilitarian properties with examples (both preclinical and clinical trials) of various natural and semisynthetic nanoparticles for the early-stage diagnosis and treatment of lung cancer.

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“…They concluded that the potential for the system was safe, non-invasive, and an effective treatment for lung. 40 Ramy Said-Elbahr et al 2016 studied about ligand conjugated mesoporous silica nanoparticles based on the enzyme targeted prodrug delivery system. Their study shows that silica nanoparticles are non-toxic and used for targeted drug delivery for cancer therapy.…”

Section: Synthetic (Organic) Nanoparticles Polymer Nanoparticles (Pns)mentioning

confidence: 99%

Nanoparticles for the Treatment of Lung Cancers

Raahulan¹,

Mallukaraj²,

Kadavakollu³

et al. 2018

JYP

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On the row of various cancers in the world, the Lung cancer falls to number two in both female and male. Various surgical and non-surgical therapeutic approaches including chemotherapy, photodynamic therapy, and radiotherapy are employed in the treatment of lung cancer. However, most of these techniques are costly, complex and lacks patient compliance. In case of chemotherapy, it is associated with lack of specific tumour targeting, with limited drug solubility leads insufficient amount of drug reaches to a tumor site. To overcome these demerits associated with chemotherapy, various types of nanoparticles (both organic and inorganic) are synthesized and studied in treating lung cancers. In this article, we have reviewed the various types of nanoparticles that have been used in treating lung cancers. This review was carried out by searches of relevant published articles, reviews and abstracts in PubMed/Medline, Web of Science, clinicaltrials.gov, Cochrane Database of Systematic Reviews and Google Scholar of all English language articles. The following search terms were used: Lung cancer, Target delivery, animal models, Nanoformulation, Nanoparticles and Polymeric Nanoparticles.

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Treatment of lung cancer via telomerase inhibition: Self-assembled nanoplexes versus polymeric nanoparticles as vectors for 2′-O-Methyl-RNA

Cited by 31 publications

References 45 publications

Cyclodextrin-based star polymers as a versatile platform for nanochemotherapeutics: Enhanced entrapment and uptake of idarubicin

Cyclodextrin-based star polymers as a versatile platform for nanochemotherapeutics: Enhanced entrapment and uptake of idarubicin

Natural and Semisynthetic Nanoparticles in Lung Cancer Diagnosis and Therapy

Nanoparticles for the Treatment of Lung Cancers

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