Treatment of Lymphedema of the Arms and Legs with 5,6-Benzo-[alpha]-pyrone

Casley‐Smith, J. R.; Morgan, R. Gwyn; Piller, Neil

doi:10.1056/nejm199310143291604

Cited by 230 publications

(131 citation statements)

References 6 publications

Supporting

Mentioning

122

Contrasting

Unclassified

Order By: Relevance

“…Only two used validated Palliative Medicine QoL instruments. 25,27 One of these two studies reported significant improvement of QoL in the treatment group, while the other was a pilot trial with insufficient power to detect any difference in QoL. All evaluated treatments appeared to be safe, although three studies did not state whether side effects were specifically assessed.…”

Section: Patient-reported Outcomes and Side Effects Of Treatmentsmentioning

confidence: 99%

See 1 more Smart Citation

The management of secondary lower limb lymphoedema in cancer patients: A systematic review

2014

View full text Add to dashboard Cite

Background: Lower limb lymphoedema is a recognised complication of cancer commonly encountered in palliative care, associated with reduced mobility and poor quality of life. Aim: To evaluate the available evidence for the treatment of secondary lower limb lymphoedema in patients with malignancies. Design: A systematic review of the literature. Data sources: The MEDLINE, Embase, LILACS, Science Citation Index, Cochrane Databases and conference proceedings for published data from date of inception to July 2014 were searched. Relevant unpublished studies via relevant databases, Internet searches and hand-searches of the bibliographies of relevant papers were performed. Results: From 1617 citations, 32 papers were selected for full-text assessment. Two randomised trials and five observational studies were identified. The two randomised controlled trials evaluated graded compression stockings and Coumarin capsules, respectively. The five observational studies evaluated lymphovenous microsurgical shunts, pneumatic compression devices, compression bandages alone, manual lymphatic drainage with compression and a herbal remedy combining Coumarin, Ginkgo and Melitoto (with or without manual lymphatic drainage), respectively. The extracted studies showed substantial heterogeneity. Hence, a meta-analysis was inappropriate and not performed. Conclusion: Few studies have evaluated the clinical effectiveness and potential side effects of treatments for lower limb lymphoedema. Moreover, symptoms and quality-of-life assessments were inconsistently reported. All included studies report lower limb volume reduction after treatment, which includes complex decongestion therapy, graded compression stockings and lymphovenous microsurgical shunts. Adequately powered randomised controlled trials of these interventions are recommended. Effort should be made to establish standardised outcomes, to minimise bias and to improve reporting quality in future trials of treatment for lower limb lymphoedema.

show abstract

Section: Patient-reported Outcomes and Side Effects Of Treatmentsmentioning

confidence: 99%

“…Although our results provided limited evidence to support current clinical decision-making, the included studies [24][25][26][27][28][29][30] could guide the planning of future studies.…”

Section: Recommendations For Future Studies On the Management Of Lllmentioning

confidence: 99%

The management of secondary lower limb lymphoedema in cancer patients: A systematic review

2014

View full text Add to dashboard Cite

show abstract

“…• Benzopyrones, such as coumarin, 6 are not available for routine use in the U.S. at this time. Although bioflavenoids 7 are readily available, long term studies have not yet documented the efficacy of this pharmacologic approach.…”

mentioning

confidence: 99%

Workgroup III

Rockson¹,

Miller²,

Senie³

et al. 1998

Cancer

123

View full text Add to dashboard Cite

“…Flavonoids help to prevent platelets sickness and hence platelets aggregation [57]. The presence of coumarin in P. amarus, E. heterophylla, P. nigrum, A. conyzoides and G. latifolium enable these plants to carry out various pharmacological activities such as edema modification, faster reabsorption of edematous fluids, treatment of lymphedema, etc [58].…”

Section: Phytochemical Screening Of Plants Extractsmentioning

confidence: 99%

Qualitative and Quantitative Phytochemical Screening of Some Plants Used in Ethnomedicine in the Niger Delta Region of Nigeria

Ajuru¹,

Williams²,

Ajuru³

2017

JFNS

View full text Add to dashboard Cite

Qualitative and quantitative phytochemical screening of six plants used in ethnomedicine in the Niger Delta region of Nigeria was carried out to identify and quantify the bioactive compounds present in these highly medicinal plants. The plants studied were Phyllanthus amarus Schum and Thonn, Euphorbia heterophylla Linn., Senna occidentalis L., Piper nigrum L., Ageratum conyzoides L. and Gongronema latifolium Benth. Ethanolic and aqueous extracts of leaves of the plant species were screened for the presence of alkaloid, anthraquinone, coumarin, flavonoid, phenol, quinone, saponin, tannin, sugar and glycoside and quantitative study was also carried out using Standard method. Qualitative study indicated the presence of all the phytochemicals in the ethanolic extracts of P. amarus and E. heterophylla, and absence of anthraquinone in S. occidentalis, P. nigrum, A. conyzoides and G. latifolium. Also, absence of coumarin in S. occidentalis, and phenol in G. latifolium. The aqueous extract indicated the presence of all the phytochemicals in A. conyzoides and presence of alkaloid, tannin, sugar and glycoside in other plant species studied. Quantitative analysis showed variable amounts of pharmacologically important secondary metabolites such as alkaloids, tannins, flavonoid, saponins and phenol in all the plants investigated. The different phytochemicals are shown to perform different biological activities in humans and animals. These compounds can be harnessed for industrial and pharmaceutical utilization.

show abstract

Treatment of Lymphedema of the Arms and Legs with 5,6-Benzo-[alpha]-pyrone

Abstract: 5,6-Benzo-[alpha]-pyrone results in slow but safe reduction of lymphedema of the extremities.

Cited by 230 publications

References 6 publications

The management of secondary lower limb lymphoedema in cancer patients: A systematic review

The management of secondary lower limb lymphoedema in cancer patients: A systematic review

Workgroup III

Qualitative and Quantitative Phytochemical Screening of Some Plants Used in Ethnomedicine in the Niger Delta Region of Nigeria

Contact Info

Product

Resources

About