Treatment of Major Depression in General Practice: A Double‐blind Comparison of Paroxetine and Lofepramine

Ca, Moon; Vince, M.

doi:10.1111/j.1742-1241.1996.tb09542.x

Cited by 18 publications

References 19 publications

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Paroxetine versus other anti-depressive agents for depression

Purgato

Papola

Gastaldon

et al. 2014

Cochrane Database of Systematic Reviews

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Some possibly clinically meaningful differences between paroxetine and other ADs exist, but no definitive conclusions can be drawn from these findings. In terms of response, there was a moderate quality of evidence that citalopram was better than paroxetine in the acute phase (six to 12 weeks), although only one study contributed data. In terms of early response to treatment (one to four weeks) there was moderate quality of evidence that mirtazapine was better than paroxetine and that paroxetine was better than reboxetine. However there was no clear evidence that paroxetine was better or worse compared with other antidepressants at increasing response to treatment at any time point. Even if some differences were identified, the findings from this review are better thought as hypothesis forming rather than hypothesis testing and it would be reassuring to see the conclusions replicated in future trials. Finally, most of included studies were at unclear or high risk of bias, and were sponsored by the drug industry. The potential for overestimation of treatment effect due to sponsorship bias should be borne in mind.

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Paroxetine versus other anti-depressive agents for depression

Purgato

Papola

Gastaldon

et al. 2014

Cochrane Database of Systematic Reviews

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Randomization in psychiatric intervention research in the general practice setting

Feltz-Cornelis

Adèr

2000

Int J Methods Psych Res

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Most studies of psychiatric interventions in general practice settings conform only in part to the requirements of randomization, placebo control and blinding as formulated by the Cochrane Collaboration. It is possible, nonetheless, to develop experimental research designs that are sufficiently near to this standard. These must deal with certain methodological issues specific to psychiatric research. This article discusses scientific standards of psychiatric research with special consideration of interventions in general practice settings. These issues are accompanied by concrete examples and suggestions on how to confront the problems. In psychiatric intervention research, equivalence studies with single-blind outcome assessment, a tested and ethically justified method, are generally used in place of placebo-controlled studies. The article also examines randomization procedures in greater depth. Randomization can be applied across trial subjects or across doctors' practices. Practical consequences of randomizing across subjects, and specific implementations of it such as crossover and pre-post designs in general practice settings, are clarified. Overall, a research design using randomization across doctors' practices is judged preferable to one that randomizes across trial subjects. One potential problem is that the control group may become too small, especially when considerable effects are expected from the intervention being studied. One might consider making the control condition smaller in the first place, or, if indicated on ethical grounds, performing an intermediate analysis and then breaking off the study as soon as a statistically significant effect has been demonstrated. Multilevel statistical techniques offer new opportunities for analysis within such designs.

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Beeinflussen Therapieleitlinien die Behandlungsqualität depressiver Erkrankungen?

Calker¹,

Berger²

2002

Depressionen

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Treatment of Major Depression in General Practice: A Double‐blind Comparison of Paroxetine and Lofepramine

Cited by 18 publications

References 19 publications

Paroxetine versus other anti-depressive agents for depression

Paroxetine versus other anti-depressive agents for depression

Randomization in psychiatric intervention research in the general practice setting

Beeinflussen Therapieleitlinien die Behandlungsqualität depressiver Erkrankungen?

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