Treatment of malaria from monotherapy to artemisinin-based combination therapy by health professionals in urban health facilities in Yaoundé, central province, Cameroon

Sayang, Collins; Gausseres, Mathieu; Vernazza-Licht, Nicole; Malvy, Denis; Bley, Daniel; Millet, Pascal

doi:10.1186/1475-2875-8-176

Cited by 31 publications

(46 citation statements)

References 9 publications

(8 reference statements)

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“…[25] This promotes drug resistance [2] and reduces the proportion of patients receiving appropriate treatment, especially when stock is in short supply. [26] Substandard, counterfeit and self-medication pose challenges to malaria interventions in Cameroon. [27,28,29] Poor legislation led to the influx of 32%, 10% and 13% of substandard and cheap chloroquine, quinine and sulphadoxine pyrimethamine respectively into Cameroon, [28] including ACT used as recommended first-line treatment of uncomplicated malaria.…”

Section: Case Managementmentioning

confidence: 99%

Enhancing Malaria Prevention in Cameroon Through Community Participation: An in-Depth Review

Mbako¹

2017

CAJPH

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Abstract:Despite 66 percent reduction in mortality between 2000 and 2015, malaria remains a major global public health problem, affecting mostly Sub-Saharan Africa. Cameroon remains endemic to malaria, with about 41 percent suffering at least one episode of malaria, annual overall mortality of 30 to 35 percent and 67 percent childhood mortality. Cameroon government's subsidy on artemisinin combination therapy (ACT) for uncomplicated malaria, intermittent preventive treatment for pregnant women (IPTp), free distribution of insecticide treated bed nets (ITNs) to pregnant women and under-fives have been more of a top-down approach, with the affected communities mainly at the receiving end. Challenges of failed adherence to test results, drug and insecticide resistance, substandard and self-medication, low ITN ownership and utilisation have been identified, especially in the rural areas. This study reviews malaria prevention in Cameroon and proposes community based context-specific complementary interventions strategies that will promote community participation in prevention and mitigate the effects of poverty towards achievement of the sustainable development goals targets for malaria. The study involved an in-depth review of secondary data from electronic and non-electronic documents. Electronic search was done in Global Health, PubMed, governmental and non-governmental organisation websites, journals and google scholar. Non-electronic documents from the University of Leeds and World Health Organisation (WHO), Geneva libraries were also used. A conceptual framework on integrated community-based approach on intervention to prevent neglected tropical diseases and infectious diseases of poverty was adapted and used, while different intervention strategies were analysed. A total of 96 publications were eligible for inclusion. Analysis of the factors influencing malaria prevention in Cameroon, reveals that current measures alone are insufficient. Therefore, a combination of multiple delivery strategies using an integrated community-based approach is likely to be more effective in breaking the transmission cycle than single programme interventions. Concurrent implementation of community mobilisation through social groups and Village Development Committees, education on house screening, training of mothers and caregivers and health promotion through environmental management were recommended as the best and most feasible strategies to complement current interventions in Cameroon.

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Section: Case Managementmentioning

confidence: 99%

Enhancing Malaria Prevention in Cameroon Through Community Participation: An in-Depth Review

Mbako¹

2017

CAJPH

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“…Furthermore, lumefantrine, widely prescribed in Africa with artemether, is well known to also select the pfmdr1 genotype leading to a lesser susceptibility to aryl amino alcohols (7,22). Added to this, the prevalence of pfmdr1 amplification may be increased by some combined formulations, such as MQ plus artesunate and MQ plus sulfadoxinepyrimethamine, used in several African countries although not supported by official health policies (14,20). The global switch from CQ to aryl amino alcohol-based ACTs would be a critical conjunction for the emergence of clones with drug resistance related to the pfmdr1 genotype.…”

Section: Case Reportmentioning

confidence: 99%

pfmdr1 Amplification Associated with Clinical Resistance to Mefloquine in West Africa: Implications for Efficacy of Artemisinin Combination Therapies

et al. 2010

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We describe here a clinical failure in the treatment with mefloquine of acute falciparum malaria contracted in Africa and associated with in vitro mefloquine resistance and pfmdr1 copy number amplification. This case raises the question of the presence and the evolution of this genotype in Africa, which is also known to alter the susceptibility to artemisinin combination therapy (ACT).

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“…In sub Saharan Africa, 80% of children less than five years old die from malaria [6,7]. In Cameroon, malaria accounts for 30% of all morbidity cases, 36% of outpatient consultations, 67% of childhood deaths and 48% of all hospital admissions [8,9].…”

Section: Introductionmentioning

confidence: 99%

Community Health Workers’ Knowledge, Attitudes and Practices Regarding Malaria Control and Prevention in Bamenda, Cameroon: A Community Based Study

N¹,

An²,

Muluh³

et al. 2017

J Health Med Inform

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Background: Malaria is a major public health problem with about 3.4 billion people at risk worldwide. Community health workers (CHWs) are being used to control and prevent malaria in Cameroonian communities. This study's objectives were to assess CHWs' knowledge, attitudes and practices and the correlates of CHWs' knowledge regarding malaria prevention and control.Methods: A community based cross sectional survey involving 135 CHWs was conducted at the Bamenda Health District from March -May 2015. Data was collected using a structured questionnaire and analysed using Epi Info version 3.5.4. Result:All the participants had heard of malaria, 97.8% of them knew malaria was transmitted by mosquitos, 95.5% of them knew the most common sign/symptom of malaria was high temperature/fever and 98.5% of the CHWs knew that sleeping under bed nets protects against mosquito bites. The attitudes of CHWs regarding malaria prevention and control were somewhat good with 97.0% of them believing malaria is a life threatening disease and 92.6% of them believing it is best treated in a hospital. Few CHWs (4.0%) believed that malaria is caused by witchcraft and 3.3% of the CHWs think malaria is best treated by traditional doctors with herbs. CHWs' practices regarding malaria were also good with most CHWs involved in distribution of nets (82.7%). Only being single had a statistically significant association with having knowledge on malaria prevention and control. Conclusion:Participants knowledge on malaria was high and their attitudes and practices regarding malaria control were also good. Only being single had a statistically significant association to having knowledge on malaria prevention and control. CHWs still need some education and training on malaria prevention/control to provide missing knowledge. Further studies involving larger samples of CHWs for longer periods of time need to be conducted to find other correlates of CHWs' knowledge on malaria prevention and control.

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Treatment of malaria from monotherapy to artemisinin-based combination therapy by health professionals in urban health facilities in Yaoundé, central province, Cameroon

Cited by 31 publications

References 9 publications

Enhancing Malaria Prevention in Cameroon Through Community Participation: An in-Depth Review

Enhancing Malaria Prevention in Cameroon Through Community Participation: An in-Depth Review

pfmdr1 Amplification Associated with Clinical Resistance to Mefloquine in West Africa: Implications for Efficacy of Artemisinin Combination Therapies

Community Health Workers’ Knowledge, Attitudes and Practices Regarding Malaria Control and Prevention in Bamenda, Cameroon: A Community Based Study

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