Treatment of Male Infertility

Palermo, Gianpiero D.; Kocent, Justin; Monahan, D.; Neri, Q.V.; Rosenwaks, Zev

doi:10.1007/978-1-4939-0659-8_18

Cited by 33 publications

(24 citation statements)

References 94 publications

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“…A gene discovery approach based on hybridization/ microarrays technologies and followed by specific target identification using high throughput sequencing are required to further our comprehension of the molecular mechanism and signaling pathways underlying the male reproductive function in general and specifically the aging process [ 282 ]. A suitable choice of the type of tissues/fluids, the stage, and the factors to be investigated are also key elements to be considered (Figure 1 ), [ 283 - 285 ].…”

Section: Introductionmentioning

confidence: 99%

Effects of increased paternal age on sperm quality, reproductive outcome and associated epigenetic risks to offspring

Sharma

Agarwal

Rohra

et al. 2015

Reprod Biol Endocrinol

328

242

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Over the last decade, there has been a significant increase in average paternal age when the first child is conceived, either due to increased life expectancy, widespread use of contraception, late marriages and other factors. While the effect of maternal ageing on fertilization and reproduction is well known and several studies have shown that women over 35 years have a higher risk of infertility, pregnancy complications, spontaneous abortion, congenital anomalies, and perinatal complications. The effect of paternal age on semen quality and reproductive function is controversial for several reasons. First, there is no universal definition for advanced paternal ageing. Secondly, the literature is full of studies with conflicting results, especially for the most common parameters tested. Advancing paternal age also has been associated with increased risk of genetic disease. Our exhaustive literature review has demonstrated negative effects on sperm quality and testicular functions with increasing paternal age. Epigenetics changes, DNA mutations along with chromosomal aneuploidies have been associated with increasing paternal age. In addition to increased risk of male infertility, paternal age has also been demonstrated to impact reproductive and fertility outcomes including a decrease in IVF/ICSI success rate and increasing rate of preterm birth. Increasing paternal age has shown to increase the incidence of different types of disorders like autism, schizophrenia, bipolar disorders, and childhood leukemia in the progeny. It is thereby essential to educate the infertile couples on the disturbing links between increased paternal age and rising disorders in their offspring, to better counsel them during their reproductive years.

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Section: Introductionmentioning

confidence: 99%

Effects of increased paternal age on sperm quality, reproductive outcome and associated epigenetic risks to offspring

Sharma

Agarwal

Rohra

et al. 2015

Reprod Biol Endocrinol

328

242

View full text Add to dashboard Cite

show abstract

“…If men do over-report male-controlled methods, our definition would over-estimate current contraceptive use and underestimate unmet need. Additionally, this study relied on women's reports of fecundity in the calculation of couple unmet need, and it is possible that we are underestimating couple infecundity due to male causes, which account for 25-50% of infertility cases in developed countries (Palermo et al 2014). If couples are not using contraception due to male infecundity, the present study may be overestimating couple unmet need.…”

Section: Discussionmentioning

confidence: 99%

Couples' Unmet Need for Family Planning in Three West African Countries

Pearson

Becker

2014

Studies in Family Planning

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Unmet need for family planning is typically calculated for currently married women, but excluding husbands may provide misleading estimates of couples’ unmet need for family planning. This study builds on previous work and proposes a method of calculating couples’ unmet need for family planning based on spouses’ independent fertility intentions. Demographic and Health Survey (DHS) couple data from West Africa are used. Across the three countries, less than half of the couples with any unmet need had concordant unmet need (41.2-48.8%). A similar percentage of couples had wife-only unmet need (33.0-40.4%). A smaller percentage had husband-only unmet need (15.1-22.9%). Calculating unmet need based only on women's fertility intentions overestimates concordant unmet need. Additionally, that approximately 15-23% of couples have husband-only unmet need suggests that men could be an entry point for contraceptive use for some couples. To calculate husbands’ unmet need, population-based surveys should consider collecting the necessary data consistently.

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“…2015 ). Indeed at our center, there has also been a progressive increase in ICSI utilization starting at 32.2% in 1993 rising to 48.8% in 1995, 73.6% by 2002 and 79.29% in 2016 ( Palermo et al . 2015 b , Dyer et al .…”

Section: Introductionmentioning

confidence: 88%

Intracytoplasmic sperm injection: state of the art in humans

et al. 2017

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Among infertile couples, 25% involve both male and female factors, while male factor alone accounts for another 25% due to oligo-, astheno-, teratozoospermia, a combination of the three, or even a complete absence of sperm cells in the ejaculate and can lead to a poor prognosis even with the help of assisted reproductive technology (ART). Intracytoplasmic sperm injection (ICSI) has been with us now for a quarter of a century and in spite of the controversy generated since its inception, it remains in the forefront of the techniques utilized in ART. The development of ICSI in 1992 has drastically decreased the impact of male factor, resulting in millions of pregnancies worldwide for couples who, without ICSI, would have had little chance of having their own biological child. This review focuses on the state of the art of ICSI regarding utility of bioassays that evaluate male factor infertility beyond the standard semen analysis and describes the current application and advances in regard to ICSI, particularly the genetic and epigenetic characteristics of spermatozoa and their impact on reproductive outcome.

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Treatment of Male Infertility

Cited by 33 publications

References 94 publications

Effects of increased paternal age on sperm quality, reproductive outcome and associated epigenetic risks to offspring

Effects of increased paternal age on sperm quality, reproductive outcome and associated epigenetic risks to offspring

Couples' Unmet Need for Family Planning in Three West African Countries

Intracytoplasmic sperm injection: state of the art in humans

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