Treatment of male pattern alopecia with platelet-rich plasma: A double-blind controlled study with analysis of platelet number and growth factor levels

Rodrigues, Bruno; Montalvão, Silmara Aparecida de Lima; Cancela, Rebeca Brito Bonani; Silva, Francesca A. R.; Urban, Aline; Huber, Stephany Cares; Júnior, José Luiz Rosenberis Cunha; Lana, José Fábio Santos Duarte; Annichinno-Bizzacchi, Joyce M.

doi:10.1016/j.jaad.2018.09.033

Cited by 73 publications

(74 citation statements)

References 16 publications

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“…Three studies applied co‐interventions (minoxidil, finasteride, or polydeoxyribonucleotide) in addition to PRP in the experimental group and applied the same intervention in the control group without PRP . The rest of 10 studies compared platelet‐rich plasma to placebo (normal saline or distilled water) . If studies included males, then the studies used the Hamilton‐Norwood classification to categorize progression of male pattern hair loss.…”

Section: Resultsmentioning

confidence: 99%

“…We included 13 RCTs. [32][33][34][35][36][37][38][39][40][41][42][43][44] Among four records retrieved from ClinicalTrials.gov, we identified two potentially relevant ongoing RCTs as follows. A study by the Wake Forest University plans to use a half-head design to compare PRP vs placebo 45 and a study by the Northwestern University plans to use a crossover design to compare PRP vs placebo.…”

Section: Data Collection and Analysismentioning

confidence: 99%

“…The 13 included studies randomized 356 participants or half heads, 343 analyzed. Seven studies [33][34][35][36][37][38][39]43 compared scalp patches between two halves of the head and the rest of six studies 32,38,[40][41][42]44 compared two groups of participants in a simple parallel design. The studies were set in various countries including Brazil, Egypt, India, Italy, Iran, Korea, Mexico, Spain, and the USA.…”

Section: Baseline Datamentioning

confidence: 99%

“…All studies appeared to be conducted in single centers. Six studies included only men, [35][36][37]39,41,42 three studies included only women, 38,40,43 and the rest of four studies included men and women. [32][33][34]44 Mean age was roughly 30-45 years ranging from 18 to 63 years.…”

Section: Baseline Datamentioning

confidence: 99%

“…In five studies, 32,34,38,41,42 the assessment resulted in the judgement of a high risk in at least one item. In one of those five studies, 34 the high risk was supported by two different types of co-interventions, though a single type of co-intervention was applied to a single person in the experimental as well as in the control group.…”

Section: Risk Of Biasmentioning

confidence: 99%

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Autologous platelet‐rich plasma therapy for pattern hair loss: A systematic review

Dervishi

Peternel

et al. 2019

J of Cosmetic Dermatology

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Background Androgenetic alopecia (male pattern and female pattern hair loss) is characterized by thinning of the scalp hair. Intradermal injection of autologous platelet‐rich plasma (PRP) might have an effect on hair regrowth. Aims The aim was to evaluate efficacy and safety of platelet‐rich plasma compared to placebo or no treatment in people with pattern hair loss. Patients/Methods We searched the databases CENTRAL and MEDLINE on December 24, 2018 and included randomized controlled trials (RCTs). Primary outcomes were mean change of hair density from baseline and serious treatment‐related adverse events. Secondary outcome was mean change of hair thickness from baseline. Time point of outcome assessment was 6 months after start of treatment. Results We identified 13 relevant randomized controlled trials with 356 randomized (343 analyzed) people or half‐head areas who received PRP in a simple parallel or half‐head design. The pooled data of seven studies (171 analyzed people or half‐head areas) were favorable in the PRP group on hair density. We estimated a mean difference from baseline of 30.35 associated with a wide 95% confidence interval (1.77‐58.93), a considerable heterogeneity (I2 = 100%), and unclear risk of bias in most of the studies. Regarding hair thickness, data were also favorable in the PRP group, but these data were limited to a single study. We did not identify serious treatment‐related adverse events. Conclusion The results of seven RCTs indicated that autologous platelet‐rich plasma was associated with an increase of hair density when compared to placebo.

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Section: Resultsmentioning

confidence: 99%