1987
DOI: 10.1200/jco.1987.5.9.1340
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Treatment of malignant lymphoma in 100 patients with chemotherapy, total body irradiation, and marrow transplantation.

Abstract: Between July 1970 and January 1985, 100 patients with malignant lymphoma were treated with high-dose chemoradiotherapy and bone marrow transplantation. Twenty-eight of the 100 are alive and the actuarial probability of disease-free survival 5 years from transplantation is 22%. The most common reason for treatment failure was disease recurrence, with an actuarial probability of 60%. A proportional hazards regression analysis showed that the likelihood of disease-free survival was less in those patients transpla… Show more

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Cited by 225 publications
(79 citation statements)
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“…The dose of etoposide was reduced by 25% in two patients (Philip et al, 1987). Moreover, long term disease free survival is around 20% in non selected groups of patient, (Takvorian et al, 1987;Appelbaum et al, 1987;Phillips et al, 1990) results not much better than those achieved with conventional salvage therapy alone. This indicates that in relapsed NHL, intensive chemotherapy with ABMT only has a place in patients who have sensitive disease and low tumour burden after salvage therapy (Philip et al, 1987;Takvorian et al, 1987).…”
Section: Patient Selectionmentioning
confidence: 95%
See 1 more Smart Citation
“…The dose of etoposide was reduced by 25% in two patients (Philip et al, 1987). Moreover, long term disease free survival is around 20% in non selected groups of patient, (Takvorian et al, 1987;Appelbaum et al, 1987;Phillips et al, 1990) results not much better than those achieved with conventional salvage therapy alone. This indicates that in relapsed NHL, intensive chemotherapy with ABMT only has a place in patients who have sensitive disease and low tumour burden after salvage therapy (Philip et al, 1987;Takvorian et al, 1987).…”
Section: Patient Selectionmentioning
confidence: 95%
“…When comparing these regimens in terms of response it is clearly crucial to be mindful of the difference in case selection (Press et al, 1991). Patients with primary resistant lymphomas and resistant relapse do particularly badly (Cabanillas et al, 1982;Cabanillas et al, 1987;Philip et al, 1987;Takvorian et al, 1987;Appelbaum et al, 1987;Phillips et al, 1990). Several othe prognostic features for relapsed lymphoma have been reported.…”
Section: Patient Selectionmentioning
confidence: 99%
“…The median time to reach more than 0.5 × 10 9 /l ANC was 16 (range, [10][11][12][13][14][15][16][17][18][19][20][21][22][23][24][25][26][27] …”
Section: Engraftmentmentioning
confidence: 99%
“…Non-randomized studies demonstrated a reduction of relapse by approximately half compared to autologous transplantation, but this advantage was upset by the high treatment-related mortality. [12][13][14][15] Nevertheless, some patients with poor prognosis NHL attain long-term clinical remissions. [16][17][18][19][20] As other hematologic malignances NHLs are characterized by non-random genetic alterations.…”
Section: Introductionmentioning
confidence: 99%
“…Several studies in patients with NHL have reported lower relapse rates after allogeneic BMT than after autologous transplant. [5][6][7][8][9] Lastly, in recent years, the risk of long-term complications such as myelodysplasia and secondary leukemias following autologous BMT for lymphoma has been recognized with increasing frequency. 10,11 If the morbidity and mortality associated with allogeneic transplantation could be reduced, then it might prove a superior alternative to autologous transplant procedures in certain patients with recurrent lymphoma.…”
mentioning
confidence: 99%