Treatment of Melanoma by Electroporation of Bacillus Calmette-Guerin

Nikolova, Biliana; Tsoneva, Iana; Peycheva, E.

doi:10.5504/bbeq.2011.0059

Cited by 5 publications

(3 citation statements)

References 15 publications

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“…Electrically induced movement, while not ideal, has not prevented EBTs from being established as safe and effective treatment options for cancer [2,3,5,17,18] and other non-cancerous pathologies [19]. However, there has been a growing emphasis in the literature on developing novel techniques for performing electroporation that reduce the intensity or extent of muscle contractions [20][21][22][23][24].…”

Section: Introductionmentioning

confidence: 99%

Advances in Therapeutic Electroporation to Mitigate Muscle Contractions

Arena¹,

Davalos²

2012

J Membra Sci Technol

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Section: Introductionmentioning

confidence: 99%

Advances in Therapeutic Electroporation to Mitigate Muscle Contractions

Arena¹,

Davalos²

2012

J Membra Sci Technol

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“…The electroporation was performed by an electroporator Chemopulse III, generating bipolar pulses, used for both in vivo and in vitro studies [3,4,6,7,15,21]. Briefly, the instrument is equipped with a large voltage control within 100–2,200 V, simplified operations, a lock against unauthorized manipulations, a battery supply, an enhanced protection against electrical hazards, an autonomy providing more than 200 electroporations with one battery charge, and a recharging time for a depleted battery of less than 10 hours [6].…”

Section: Methodsmentioning

confidence: 99%

Fluorescent Imaging for Assessment of the Effect of Combined Application of Electroporation and Rifampicin on HaCaT Cells as a New Therapeutic Approach for Psoriasis

Nikolova

Kostadinova

Dimitrov

et al. 2013

Sensors

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The study aimed to clarify the role of electric pulses in combination with chemotherapy on the viability of keratinocyte cell line HaCaT, in the context of its application as a new therapeutic approach for psoriasis. The data show that electroporation of HaCaT cells in combination with rifampicin induces cytoskeleton disruption and increases permeability of cell monolayer due to cell-cell junctions' interruption, visualized by fluorescent imaging of E-cadherin and actin integrity. This was accompanied with synergistic reduction of cell viability. The study proposes a new opportunity for more effective skin treatment than chemotherapy. The future application of this electrochemotherapeutic approach for combined local treatment of psoriasis may have serous benefits because of a high possibility to avoid side-effects of conventional chemotherapy.

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“…this pulse sequence has been optimized during long series of clinical tests with companion animals (20,21,22) and human patients and was implemented in a family of instruments currently used in the medical practice (14,16).…”

Section: New Modality For Electrochemotherapy Of Surface Tumorsmentioning

confidence: 99%