“…When compared with ILP, ILI is technically simpler, has a significantly shorter treatment duration, may be considered in a broader group of patients (medically compromised, frail and elderly patients), and is possible with regional anesthesia. 32 Melphalan, a nitrogen mustard alkylating agent, is the chemotherapeutic agent most commonly used with ILP/ILI. Modification of melphalan-based regimens with addition of tumor necrosis factor alpha (TNF) has been well described with somewhat conflicting outcomes.…”