Treatment of Melanotic Freckle With X-rays

Assessment of changes in lentigo maligna during radiotherapy byin-vivoreflectance confocal microscopy: a pilot study

“…In addition, permanent hair loss, less good cosmetic results on the body or the extremities, and radiodermatitis are further challenges . Treatment failures have also been reported, especially in the U.S.A . Although imiquimod has been shown to be an effective alternative with self‐administration and reduced costs of treatment, radiotherapy still has its place as individual therapy, especially in patients with limited compliance.…”

A retrospective study of 150 patients with lentigo maligna and lentigo maligna melanoma and the efficacy of radiotherapy using Grenz or soft X-rays

“…X‐ray 16 therapy has been used in Europe for many years as the primary treatment for LM using the Miescher technique, with a success rate of 95% 17 . This technique uses high doses of Grenz or soft X‐rays (12–50 kV) 16,17 . For over 50 years, conventional fractionated radiotherapy has been used at the Department of Dermatology, University of Zurich (Switzerland) as a treatment modality for selected patients.…”

Surgery of Extensive, Subclinical Lentigo Maligna

“…In the European literature, the Miescher technique of radiotherapy of lentigo maligna has been used with reported success 11,12 . This superficial radiation technique was used by Kopf and associates and discontinued 4 . Of sixteen patients, five had recurrences or persistence of their lesions.…”

“…Lentigo maligna is histologically a superficial lesion since the atypical melanocytes are located along the basal layer of the epidermis. However, atypical melanocytes can also be found along the basal layer of the external sheath of the hair follicle and even along the sweat gland apparatus 4 . Therefore, any resective or ablative procedure should involve the deepest level of the adnexal structures in the adipose layers.…”