Treatment of Metastatic Breast Cancer with Trastuzumab and Vinorelbine During Pregnancy

Fanale, Michelle A.; Uyei, Anne; Theriault, Richard L.; Adam, Karolina; Thompson, Rachel

doi:10.3816/cbc.2005.n.040

Cited by 88 publications

(51 citation statements)

References 15 publications

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“…Finally, there are only case reports documenting the use of trastuzumab on pregnancy. Watson describes a case of reversible anhydramnios, while two other case reports report no immediate fetal or neonatal complications [74][75][76]. Tamoxifen therapy during pregnancy has been associated with ambiguous genitalia and Goldenhar's syndrome while other authors note no fetal/neonatal complication [77][78][79][80][81][82].…”

Section: Systemic Therapymentioning

confidence: 97%

Pregnancy-Associated Breast Cancer: A Literature Review

Barnes

Newman

2007

Surgical Clinics of North America

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Breast cancer, along with cervical cancer, is one of the most commonly diagnosed cancers of pregnancy. Most would define gestational breast cancer as breast cancer that is diagnosed during pregnancy, lactation, and up to 12 months post-partum. The diagnostic and therapeutic implications in this clinical setting are special. These women typically present with a more advanced-stage disease that carries an associated poorer prognosis. Physicians thus are challenged to balance aggressive maternal care with appropriate modifications that will ensure fetal protection. . Of women diagnosed with breast cancer younger than 40 years, only approximately 10% will be pregnant [2,3]. These data certainly suggest a low incidence of pregnancy-associated breast cancer. In fact, historically, the incidence is estimated at 1 in 3000 pregnancies [4][5][6]. Despite the overall low incidence, however, gestational breast cancer is one of the most common pregnancy-associated malignancies, second only to cervical cancer [4,6]. Notably, many have offered that this incidence will only increase as more women delay childbearing until later in life [4,7]. This concern is based on the fact that pregnancy-associated breast cancer is age-related, and women

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Section: Systemic Therapymentioning

confidence: 97%

Pregnancy-Associated Breast Cancer: A Literature Review

Barnes

Newman

2007

Surgical Clinics of North America

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“…These have concentrated on the fetal effects; there were three cases of anhydramnios 2,7,8 and three cases of neonatal respiratory distress. 6,9,10 Out of these seven cases there has been one infant death due to multi-organ failure 10 and one pregnancy with no fetal or maternal complications. 11 Trastuzamab does cross the placenta and it is known that the epidermal growth factor receptor group which includes HER2 does play a crucial role in fetal renal and pulmonary development.…”

Section: Discussionmentioning

confidence: 99%

Trastuzamab (Herceptin^®)-related cardiotoxicity in pregnancy

Roberts

Auld

2010

J R Soc Med

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“…To date, a total of 15 breast cancer patients have been reported to have been exposed to trastuzumab during pregnancy [40][41][42][43][44][45][46][47][48][49][50][51][52][53]. In four cases, the patients elected to receive trastuzumab following the first trimester (i.e., the period of organogenesis) [42,43,45,51].…”

Section: Trastuzumab In Pregnancymentioning

confidence: 99%

“…In four cases, the patients elected to receive trastuzumab following the first trimester (i.e., the period of organogenesis) [42,43,45,51]. The remaining cases unintentionally became pregnant during the course of trastuzumab.…”

Section: Trastuzumab In Pregnancymentioning

confidence: 99%