Treatment of metastatic lung cancer via inhalation administration of curcumin composite particles based on mesoporous silica

Su, Wenqiang; Wei, Tongxin; Lu, Manqi; Meng, Zhiping; Chen, Xuanyu; Jie, Jing; Li, Junsong; Yao, Weiwei; Zhu, Hua; Fu, Tingming

doi:10.1016/j.ejps.2019.04.025

Cited by 32 publications

(21 citation statements)

References 38 publications

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“…Las paredes de los poros de MSNs tienen una alta densidad de grupos silanoles en la superficie que pueden reaccionar frente a moléculas huésped apropiadas (Sousa et al, 2008). Dichos materiales, tienen la ventaja de ser biocompatibles y bioactivos, por lo que han adquirido diversas aplicaciones, tales como: liberación controlada de fármacos (Vivero-Escoto et al, 2009;Ferreira et al, 2018;Gema et al, 2017;Zanjanizadeh et al, 2018), regeneración de tejido óseo (Su et al, 2012;Lozano et al, 2012;Yachao et al, 2018) o aplicados para la liberación de drogas en células cancerosas (Wang et al, 2011;Su et al,2019).…”

Section: Resultados Materiales Mesoporosos Empleados En La Bioingenieria Del Tejido óSeounclassified

Aplicaciones De Materiales Mesoporosos en La Ingeniería Del Tejido Óseo

Contreras-Vargas¹,

Noris-Suárez²,

González

2021

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La ingeniería de tejidos se define como un área multidisciplinaria e interdisciplinaria cuya función principal es proponer soluciones novedosas que promuevan la regeneración o reemplazo de tejidos dañados. Las patologías óseas han sido tratadas tradicionalmente con implantes de tejido donado (injertos, aloinjertos o xenoinjertos), sin embargo, dichos tratamientos han presentado limitaciones que han promovido el desarrollo y evolución de nuevas estrategias, como es el desarrollo de la ingeniería de tejidos y de biomateriales que puedan fungir como andamios y/o matrices que puedan funcionar como liberadores de drogas. En este sentido, los materiales mesoporosos se proponen como biomateriales bioactivos, cuya característica resaltante es la gran área superficial que presentan debido a sus canales de dimensiones nanométricas. En los últimos años se ha tenido un especial interés en la sílice mesoporosa, ya que es capaz de adsorber una alta cantidad de fármaco y proporcionar una liberación controlada del mismo; también ha resultado ser estimuladora de la osteogénesis aplicándose con grandes expectativas en la regeneración ósea. El presente artículo hace una revisión de las aplicaciones de los materiales mesoporosos a base de sílice en la ingeniería del tejido óseo, tomando en cuenta la importancia del tamaño del poro y biocompatibilidad en el momento de emplearlos como sistemas de adhesión de células y liberación de fármacos.

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Section: Resultados Materiales Mesoporosos Empleados En La Bioingenieria Del Tejido óSeounclassified

Aplicaciones De Materiales Mesoporosos en La Ingeniería Del Tejido Óseo

Contreras-Vargas¹,

Noris-Suárez²,

González

2021

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“…The properties of nanostructured silica in to carry, to protect, and to deliver the entrapped antigens or compounds are attributed to its hexagonal nanostructured pores, which protect compounds against proteolysis, organic solvents, high shear stresses, and low pH (57,76,77). Previous data from our group demonstrated that silica does not alter some of the mediators known to be responsible for the antinociceptive effect of CTX (37).…”

Section: Discussionmentioning

confidence: 99%

The Crotoxin:SBA-15 Complex Down-Regulates the Incidence and Intensity of Experimental Autoimmune Encephalomyelitis Through Peripheral and Central Actions

et al. 2020

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Crotoxin (CTX), the main neurotoxin from Crotalus durissus terrificus snake venom, has antiinflammatory, immunomodulatory and antinociceptive activities. However, the CTX-induced toxicity may compromise its use. Under this scenario, the use of nanoparticle such as nanostructured mesoporous silica (SBA-15) as a carrier might become a feasible approach to improve CTX safety. Here, we determined the benefits of SBA-15 on CTX-related neuroinflammatory and immunomodulatory properties during experimental autoimmune encephalomyelitis (EAE), an animal model of multiple sclerosis that replicates several histopathological and immunological features observed in humans. We showed that a single administration of CTX:SBA-15 (54 mg/kg) was more effective in reducing pain and ameliorated the clinical score (motor impairment) in EAE animals compared to the CTXtreated EAE group; therefore, improving the disease outcome. Of interest, CTX:SBA-15, but not unconjugated CTX, prevented EAE-induced atrophy and loss of muscle function. Further supporting an immune mechanism, CTX:SBA-15 treatment reduced both recruitment and proliferation of peripheral Th17 cells as well as diminished IL-17 expression and glial cells activation in the spinal cord in EAE animals when compared with CTX-treated EAE group. Finally, CTX:SBA-15, but not unconjugated CTX, prevented the EAE-induced cell infiltration in the CNS. These results provide evidence that SBA-15 maximizes the immunomodulatory and anti-inflammatory effects of CTX in an EAE model; therefore, suggesting that SBA-15 has the potential to improve CTX effectiveness in the treatment of MS.

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“…Low dose curcumin even for the long-term, has been found to eliminate curcumin’s carcinogenic problem and helped to alleviate therapy resistance opening the possibility for combination with other treatments [ 105 , 106 ]. To solve the bioavailability issue, a technique employing inhalable curcumin composite particles for direct lung delivery was recently introduced [ 107 ].…”

Section: The Potential Use Of Phytochemical Compounds For Prevention and Targeting Cscs In Lung Cancermentioning

confidence: 99%

Understanding Lung Carcinogenesis from a Morphostatic Perspective: Prevention and Therapeutic Potential of Phytochemicals for Targeting Cancer Stem Cells

Heng

Kruyt

Cheah

2021

IJMS

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Lung cancer is still one of the deadliest cancers, with over two million incidences annually. Prevention is regarded as the most efficient way to reduce both the incidence and death figures. Nevertheless, treatment should still be improved, particularly in addressing therapeutic resistance due to cancer stem cells—the assumed drivers of tumor initiation and progression. Phytochemicals in plant-based diets are thought to contribute substantially to lung cancer prevention and may be efficacious for targeting lung cancer stem cells. In this review, we collect recent literature on lung homeostasis, carcinogenesis, and phytochemicals studied in lung cancers. We provide a comprehensive overview of how normal lung tissue operates and relate it with lung carcinogenesis to redefine better targets for lung cancer stem cells. Nine well-studied phytochemical compounds, namely curcumin, resveratrol, quercetin, epigallocatechin-3-gallate, luteolin, sulforaphane, berberine, genistein, and capsaicin, are discussed in terms of their chemopreventive and anticancer mechanisms in lung cancer and potential use in the clinic. How the use of phytochemicals can be improved by structural manipulations, targeted delivery, concentration adjustments, and combinatorial treatments is also highlighted. We propose that lung carcinomas should be treated differently based on their respective cellular origins. Targeting quiescence-inducing, inflammation-dampening, or reactive oxygen species-balancing pathways appears particularly interesting.

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Treatment of metastatic lung cancer via inhalation administration of curcumin composite particles based on mesoporous silica

Cited by 32 publications

References 38 publications

Aplicaciones De Materiales Mesoporosos en La Ingeniería Del Tejido Óseo

Aplicaciones De Materiales Mesoporosos en La Ingeniería Del Tejido Óseo

The Crotoxin:SBA-15 Complex Down-Regulates the Incidence and Intensity of Experimental Autoimmune Encephalomyelitis Through Peripheral and Central Actions

Understanding Lung Carcinogenesis from a Morphostatic Perspective: Prevention and Therapeutic Potential of Phytochemicals for Targeting Cancer Stem Cells

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