Treatment of Mild-to-Moderate Hypertension

Determination of doxazosin and verapamil in human serum by fast LC–MS/MS: Application to document non-compliance of patients

“…Exclusion of secondary hypertension, including endocrine hypertension (mainly primary aldosteronism, but also pheochromocytoma and hypercortisolism) is recommended in these patients. Therefore the patients are switched to a drug combination of alpha 1 adrenoreceptor antagonists (A1AAs) [2,3] and/or calcium channel blockers (CCBs) [4][5][6], which does not affect plasma concentration of the endogenous hormones connected to secondary hypertension. Doxazosin and verapamil ( Fig.…”