Treatment of MN subgroup incompatibility with intravenous immunoglobulin in a newborn

Abstract

Key wordsanti-M , hemolytic disease of the newborn , intravenous immunoglobulin .

Hemolytic Disease of the Newborn Caused by Irregular Blood Subgroup (Kell, C, c, E, and e) Incompatibilities: Report of 106 Cases at a Tertiary-Care Centre

“…15,20,21 There are only few reports about the use of IVIG in hemolytic disease of newborn due to subgroup incompatibility. 5,9,20 Although the exact mechanism of action of IVIG is still unknown, it is thought to exert its effect mainly through Fc receptor blockade of the reticuloendothelial system. IVIG therapy was shown to reduce the need for exchange transfusions in babies with RhD and ABO hemolytic disease.…”

“…Many different blood group systems such as RhD, ABO, Kidd, Duffy, MNS, Kell, C, and E systems have been reported as causes of hemolysis in the newborn period. [1][2][3][4][5][6] Treatment modalities for the hemolytic disease of the newborn are phototherapy, exchange transfusion, and intrauterine or extrauterine transfusion in selected cases. Highdose intravenous immunoglobulin (IVIG) therapy has been suggested also as an alternative therapy for isoimmune hemolytic jaundice observed in neonates to reduce the need for exchange transfusion.…”

“…Highdose intravenous immunoglobulin (IVIG) therapy has been suggested also as an alternative therapy for isoimmune hemolytic jaundice observed in neonates to reduce the need for exchange transfusion. 5,[7][8][9] There is a paucity of data regarding the significance and therapeutic management of Kell, C, c, E, and e subgroup incompatibilities on neonatal hyperbilirubinemia. The aim of this study was therefore to determine the clinical spectrum of hemolytic disease due to irregular blood subgroups incompatibility in hospitalized neonates.…”