Treatment of multiple brain metastases using gadolinium nanoparticles and radiotherapy: NANO-RAD, a phase I study protocol

Verry, Camille; Sancey, Lucie; Dufort, Sandrine; Duc, Géraldine Le; Mendoza, Carmen; Lux, François; Grand, Sylvie; Arnaud, Josiane; Quesada, Javier Luna; Villa, Julie; Tillement, Olivier; Balosso, Jacques

doi:10.1136/bmjopen-2018-023591

Cited by 111 publications

(106 citation statements)

References 28 publications

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“…Although there are currently no nanoparticles approved for radiotherapy, several of them are being investigated in clinical studies. Nanoparticles made of polysiloxane matrix and gadolinium chelates (AGuIX; NCT02820454) have undergone a phase 1 study for treating patients with multiple brain metastases through whole brain radiotherapy [147]. Hafnium oxide nanoparticles (NBTXR3) are under a phase 1-2 study for treating liver cancer patients in conjunction with stereotactic body radiation therapy (NCT02721056).…”

Section: Current Challenges and Clinical Translationmentioning

confidence: 99%

Nanoparticles for targeted cancer radiotherapy

Pallares

Abergel

2020

Nano Res.

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Radiotherapy, where ionizing radiation is locally delivered either through an external beam or by surgically implanting radionuclidebased seeds in the tumor, is one of the gold standard treatments for cancer. Due to the non-selective nature of radiation, healthy tissue surrounding the cancerous region is usually affected by the treatment. Hence, new strategies, including targeted alpha therapy, are being studied to improve the selectivity of the treatment and minimize side effects. Several challenges, however, limit the current development of targeted radiotherapy, such as the functionalization of the therapeutic agent with targeting vectors and controlling the release of recoiling daughters. Nanoparticles offer unique opportunities as drug delivery vehicles, since they are biocompatible, enhance the cellular uptake of drugs, and are easily functionalized with targeting molecules. In this review, we examine how nanoparticles can be used for targeted radiotherapy, either as sensitizers of external beams or as delivery vehicles for therapeutic radionuclides. We describe the clinical relevance of different types of nanoparticles, followed by an analysis of how these nanoconstructs can solve some of the main limitations of conventional radiotherapy. Finally, we critically discuss the current situation of nanoparticle-based radiotherapy in clinical settings and challenges that need to be overcome in the future for further development of the field.

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Section: Current Challenges and Clinical Translationmentioning

confidence: 99%

Nanoparticles for targeted cancer radiotherapy

Pallares

Abergel

2020

Nano Res.

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“…Nowadays, ultrasmall nanoparticles (1-3 nm cores) are widely used for medical applications because of their advantages regarding biodistribution, targeting features, adsorption, easy surface modifications and pharmacokinetics [18,[41][42][43]. Gadolinium ultrasmall nanoparticles achieved theranostic potential without considerable toxicity in vivo in the case of brain cancers [44]. Another example is represented by ultrasmall silica nanoparticles functionalized with antibody fragments used to target HER2-overexpressed breast cancer as imaging agents [42].…”

Section: Engineered Nanomaterials -Health and Safetymentioning

confidence: 99%

Theranostic Nanoparticles and Their Spectrum in Cancer

Onaciu¹,

Jurj²,

Moldovan³

et al. 2020

Engineered Nanomaterials - Health and Safety

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Nanoparticles offer a lot of advantageous backgrounds for many applications due to their physical, chemical and biological properties. Their different composition (metals, lipids, polymers, peptides) and shapes (spheres, rods, pyramids, flowers and so on) are influenced by the synthesis methods and functionalization procedures. However, in the medical field, researchers focus on the biocompatibility and biodegradability of the nanoparticles in their attempts for a targeted therapy in which the nanocarriers need to bypass certain biological barriers. Moreover, the increased interest in molecular imaging has brought nanoparticles in the spotlight for their applications in two distinct directions: therapy and diagnosis. Furthermore, recent advances in nanoparticle designs have introduced novel nano-objects suitable as both detection and delivery systems at the same time, thus providing theranostic applications.

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“…These nanoparticles are also used in liver and head and neck tumors and oligometastases. Other nanoparticles have been used with a theranostic approach (i.e., with imaging and therapeutic aims), such as gadolinium nanoparticles [162]. Several early-phase trials have been initiated (see ClinicalTrials.gov).…”

Section: Nanoparticle-enhanced Radiationmentioning

confidence: 99%

Hadrontherapy Interactions in Molecular and Cellular Biology

Thariat

Valable

Laurent

et al. 2019

IJMS

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The resistance of cancer cells to radiotherapy is a major issue in the curative treatment of cancer patients. This resistance can be intrinsic or acquired after irradiation and has various definitions, depending on the endpoint that is chosen in assessing the response to radiation. This phenomenon might be strengthened by the radiosensitivity of surrounding healthy tissues. Sensitive organs near the tumor that is to be treated can be affected by direct irradiation or experience nontargeted reactions, leading to early or late effects that disrupt the quality of life of patients. For several decades, new modalities of irradiation that involve accelerated particles have been available, such as proton therapy and carbon therapy, raising the possibility of specifically targeting the tumor volume. The goal of this review is to examine the up-to-date radiobiological and clinical aspects of hadrontherapy, a discipline that is maturing, with promising applications. We first describe the physical and biological advantages of particles and their application in cancer treatment. The contribution of the microenvironment and surrounding healthy tissues to tumor radioresistance is then discussed, in relation to imaging and accurate visualization of potentially resistant hypoxic areas using dedicated markers, to identify patients and tumors that could benefit from hadrontherapy over conventional irradiation. Finally, we consider combined treatment strategies to improve the particle therapy of radioresistant cancers.

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Treatment of multiple brain metastases using gadolinium nanoparticles and radiotherapy: NANO-RAD, a phase I study protocol

Cited by 111 publications

References 28 publications

Nanoparticles for targeted cancer radiotherapy

Nanoparticles for targeted cancer radiotherapy

Theranostic Nanoparticles and Their Spectrum in Cancer

Hadrontherapy Interactions in Molecular and Cellular Biology

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