Treatment of multiple eccrine hidrocystomas with isotretinoin followed by carbon dioxide laser

Park, Hyun C.; Kim, Eun J.; Kim, Jeong Eun; Ro, Young Suck; Ko, Joo Yeon

doi:10.1111/1346-8138.12059

Cited by 11 publications

(9 citation statements)

References 4 publications

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“…Han et al 19 described a case of cutaneous Rosai‐Dorfman Disease managed with 10 mg twice daily isotretinoin and pulsed dye laser treatment with no adverse events. Park et al 21 treated a 57‐year‐old woman with multiple eccrine hidrocystoma with 20 mg daily isotretinoin followed by a single CO 2 laser session. Good effect was achieved, though eventually the lesion recurred.…”

Section: Resultsmentioning

confidence: 99%

“…It is important to consider the limitation of all studies included in this review, including pre‐intervention (eg, confounding, selection), peri‐intervention (eg, classification), and post‐intervention (eg, reporting) bias. Eight studies 7,8,18,19,21,22,29,31 were critically biased due to the inherent limitations of case reports and expert opinions of selective reporting and negative self‐controls. The remainder were moderately biased, due to no pre‐registered protocols, variable isotretinoin dosages and laser settings, and the subjective nature of outcome measures.…”

Section: Discussionmentioning

confidence: 99%

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Concomitant use of isotretinoin and lasers with implications for future guidelines: An updated systematic review

Mirza

Khatri

2020

Dermatologic Therapy

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It is generally believed that intervention on skin while on isotretinoin or within 6 to 12 months after treatment can lead to prolonged healing and abnormal scarring. The objective of this systematic review is to evaluate the body of evidence on concomitant use of isotretinoin and lasers for adverse events as a consequence of treatment. A PRISMA-compliant systematic review (Systematic Review Registration Number: CRD42017056492) of 12 electronic databases was conducted for the terms "laser" and "isotretinoin" or associated brand names from inception until June 2020. Subsequent reference search of studies meeting predefined inclusion criteria were conducted, and all articles were evaluated for bias and assigned levels of evidence to facilitate data synthesis. The search strategy produced 29 studies. Of 871 patients included in the studies of interest, 12 experienced transient adverse effects that resolved spontaneously, and only two presented with keloid formation, both from case reports. This systematic review suggests the risk associated with concomitant isotretinoin and laser use is small to absent. Further studies are needed, but these results suggest that current contraindications may be overly cautious.

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Section: Resultsmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Concomitant use of isotretinoin and lasers with implications for future guidelines: An updated systematic review

Mirza

Khatri

2020

Dermatologic Therapy

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“…Although seborrhea recurred after the cessation of isotretinoin, the papular, dome-shaped hidrocystoma lesions showed significant improvement during an 8-month follow-up period. 32…”

Section: Oral Isotretinoin and Concomitant Skin Treatment Chemical Pementioning

confidence: 99%

Indications and Use of Isotretinoin in Facial Plastic Surgery

et al. 2018

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Isotretinoin is a first generation retinoid with pleiotropic effects on keratinocyte differentiation, proliferation, and activity of sebaceous glands. For years, there has been intense debate on whether the use of isotretinoin combined with cosmetic or surgical procedures is safe and potentially more efficient than either therapy alone. Due to delays in wound healing and keloid formation, conservative recommendations were not to combine isotretinoin with any plastic surgery or local treatment at 6 to 12 months after discontinuation of the drug. However, there is increasing evidence that a combination approach is not only safe, but may also provide excellent cosmetic outcomes in acne scars, sebaceous gland hyperplasia, and thick-skinned patients undergoing facial plastic surgery. In particular, low-dose regimens of isotretinoin may offer advantages over standard dosage treatments because of better tolerability and safety in long-term use adjunct with surgical interventions. In this article, the authors aim to summarize the current evidence on the use of isotretinoin in facial plastic surgery and to share their experience from selected patients.

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“…A solitary lesion can be excised, but excision of multiple lesions is impractical and may lead to scarring. One case involved a combination of isotretinoin orally for 6 weeks followed by ultrapulse CO 2 laser, which resulted in semi‐permanent removal of the lesions . Various topical agents have been tried, including topical atropine ointment 1% or scopolamine cream 0.01% (1.2 mL of scopolamine 0.25% eyedrops in 30 g of emollient cream) applied once daily, though anticholinergic adverse effects (AEs) such as mydriasis can be a deterrent to its use.…”

mentioning

confidence: 99%

“…One case involved a combination of isotretinoin orally for 6 weeks followed by ultrapulse CO 2 laser, which resulted in semi-permanent removal of the lesions. 2 Various topical agents have been tried, including topical atropine ointment 1% or scopolamine cream 0.01% (1.2 mL of scopolamine 0.25% eyedrops in 30 g of emollient cream) applied once daily, though anticholinergic adverse effects (AEs) such as mydriasis can be a deterrent to its use. One report described the successful treatment of multiple facial EHs associated with craniofacial hyperhidrosis, using glycopyrrolate 0.5% aqueous solution applied locally for 1 week.…”

mentioning

confidence: 99%

A simple, safe and cheap treatment of eccrine hidrocystomas: topical aluminium hexachloride

2018

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Treatment of multiple eccrine hidrocystomas with isotretinoin followed by carbon dioxide laser

Cited by 11 publications

References 4 publications

Concomitant use of isotretinoin and lasers with implications for future guidelines: An updated systematic review

Concomitant use of isotretinoin and lasers with implications for future guidelines: An updated systematic review

Indications and Use of Isotretinoin in Facial Plastic Surgery

A simple, safe and cheap treatment of eccrine hidrocystomas: topical aluminium hexachloride

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