Treatment of Mycosis Fungoides With 6-Azauracilriboside

Záruba, F

doi:10.1016/s0140-6736(63)91003-1

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1967

1975

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Cited by 16 publications

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“…The reaction seen in rheumatoid arthritis after 6-AzUrd-TA tends to point to an activation of the basic pathological process. As already stated, 6-AzUrd-TA is very weIl tolerated in psoriasis.t?-11 in mycosis fungoides, 12 in herpes," and in smallpox," even in doses over 250 mg. per kilogram per day. In rheumatoid arthritis this is not so, although there is dose dependence.…”

Section: Discussionmentioning

confidence: 85%

Side effects of 6‐azauridine triacetate in rheumatoid arthritis

Elis

Slavik

Rašková

1970

Clin Pharma and Therapeutics

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Section: Discussionmentioning

confidence: 85%

Side effects of 6‐azauridine triacetate in rheumatoid arthritis

Elis

Slavik

Rašková

1970

Clin Pharma and Therapeutics

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Pharmacological Differences, Qualitative and Quantitative, Between Man and Other Species

Welch

1967

Novartis Foundation Symposia

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Teratogenic effect of 6‐azauridine in rats

1971

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The embryotoxic effects of 6-azauridine, given during different periods of gestation in rats, are described. Administration on days 1-6 was lethal or without any effect. Days 6-12 was the period of greatest embryonic susceptibility. 330 and 110 mg/kg caused 100% resorption; 36 mg/kg embryolethality in 85%, teratogenicity in 53.8%. After 12 mg/kg 5.8% of the fetuses were malformed, mostly with encephalocele and gastroschisis. Administered on days 12-18, 3 g/kg was 100% embryolethal and 1 g/kg 32.7% embryolethal and 100% teratogenic, causing malformations of extremities. After 330 mg/kg 65.2% of fetuses survived without any visible damage. Following single administrations of 6-azauridine embryolethality was commonest after 3 g/kg on days 8 and 11. The teratogenic effect was best expressed after 3 g/kg on day 15, 1 g/kg on day 13, and 330 mg/kg on day 8. Malformations observed were cleft palate, gastroschisis, and dysmelia.

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Treatment of Mycosis Fungoides With 6-Azauracilriboside

Cited by 16 publications

References 0 publications

Side effects of 6‐azauridine triacetate in rheumatoid arthritis

Side effects of 6‐azauridine triacetate in rheumatoid arthritis

Pharmacological Differences, Qualitative and Quantitative, Between Man and Other Species

Teratogenic effect of 6‐azauridine in rats

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