here is a wealth of literature dedicated to the pathogenesis, diagnosis, and clinical behavior of infantile hemangiomas (IHs), which are the most common benign tumors of infancy. Therapeutic strategies, however, are less well studied, and continue to evolve as laser, surgical, and medical interventions are refined to attain the best cosmetic and functional outcomes. Infantile hemangiomas of the nose (IHNs) comprise a special subset of these tumors owing to their effect on a structure with known functional, aesthetic, and psychosocial importance. Because of the relatively low incidence of IHNs, the timing, type, duration, and extent of treatment are topics of debate. Recently, a more aggressive approach for a wider range of tumors has been gaining strength because of the excellent efficacy and safety profile of β-blockers and the availability of a US Food and Drug Administration-approved formulation for infants with IHs. [1][2][3] The paucity of outcomes data for management of IHN, however, makes planning of generalized treatment difficult. Because of this difficulty, we hypothesized that a standardized therapeutic protocol for IHNs that is capable of achieving acceptable aesthetic and functional outcomes by 2.5 to 3 years of age (when a sense of self begins to form) could be developed from consensus literature reports and personal experience. 1,4 To address this hypothesis, we performed a retrospective record review of treatment approaches and outcomes in our patient population and compared this experience with that in the literature.
Methods
Primary StudyWe performed a retrospective review of all patients with IHNs treated by a single surgeon (M.H.) in a tertiary referral private practice between January 1, 1999, and December 31, 2015. Inclusion criteria were diagnosis of IHN, documentation of medical and/or surgical interventions, and duration of follow-up of 1 year or more. Patients were excluded if management consisted solely of observation for tumors or anomalies other than IHNs and if the IHN was confined solely to the glabella. Patient records were mined for demographic data, tumor-specific variables, clinical data, therapeutic interventions, and outcomes. Tumor-specific variables were as follows: (1) depth of involvement, characterized as superficial lesions extending to the dermis only, deep lesions confined to the subcutaneous or subdermal tissue, and compound lesions with simultaneous superficial and deep components; (2) tumor distribution, characterized as focal tumors involved in solitary nasal subunits and segmental tumors involved in multifocal and/or dermatomal distributions; and (3) tumor life IMPORTANCE Current treatment approaches for infantile hemangiomas of the nose include observation, pharmacologic agents, surgery, and/or laser therapy. Because of the known functional, social, and cosmetic effect of nasal deformities, obtaining the best possible result is critical. Optimal timing, type, duration, and extent of therapy remain unclear.OBSERVATIONS Results of a review of 86 patients (64 female...