Treatment of nasal polyps with intranasal beclomethasone dipropionate aerosol

Mygind, Niels; Pedersen, Carsten; Prytz, S.; Sørensen, H.

doi:10.1111/j.1365-2222.1975.tb01848.x

Cited by 100 publications

(51 citation statements)

References 4 publications

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“…On rare occasions, polyps may arise from the turbinates, and sometimes also from the maxillary sinuses, then constitut ing the so-called antrochoanal polyps. The symptoms, treatment and histology of nasal polyps are well docu mented [1][2][3][4][5][6][7][8], However, in a recent study by Larsen and Tos [9], support is given that the nasal polyp may origi nate from the nasal mucosa, but the study cannot pre clude the presence of underlying ethmoid involvement.…”

Section: Introductionmentioning

confidence: 99%

The So-Called ‘Allergic’ Nasal Polyp

Davidsson¹,

Hellquist²

1993

ORL

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A series of 95 consecutive patients who have had a polypectomy was investigated with regard to clinical history and the morphology of the polyps. The results were compared with a series of 203 patients with allergy, of whom 12 had been polypectomized. The study revealed that a high percentage of the 95 patients had subjective complaints, particularly nasal congestion, nasal discharge, sneezing, headache, snoring and a loss of smell. The latter was present in nearly 58 % of the patients, and persisted long after the operation in a third of the cases. More than 50 % of the 95 patients had had 3 or more polypectomies. Rather few patients suffered from allergy-like conditions. Eighty-two of the 95 polyps were of the ordinary, oedematous, eosinophilic type; 7 were neutrophilic, fibro-inflammatory; 5 showed pronounced hyperplasia of the seromucinous glands, and 1 was a so-called polyp with atypical stroma. Only 6 % of the 203 patients with allergy had had a polypectomy. Ten of the 12 polyps removed from the series of patients with allergy were of the ordinary type and 2 of the fibro-inflammatory type. A review of the literature is done concerning the association between nasal polyp and different diseases. The results of the present study support the concept that allergy is not the only cause for nasal polyps and that the accumulation of eosinophilic granulocytes observed in most polyps is often not related to allergy.

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Section: Introductionmentioning

confidence: 99%

The So-Called ‘Allergic’ Nasal Polyp

Davidsson¹,

Hellquist²

1993

ORL

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“…Topical GCS treatment has been shown to reduce polyp size, as well as the associated nasal symptoms (38,71,108). Even more interesting is the finding that GCS treatment after a polypectomy reduces the number of recurrences, especially in patients who have previously been subjected to frequent polypectomies (42,79).…”

Section: Nasal Polypsmentioning

confidence: 89%

Glucocorticosteroids and rhinitis

Mygind

1993

Allergy

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“…Several randomized clinical trials have shown these medications to be effective treatments for NP (table 1) [8,13,64,65,66,67,68,69,70,71,72,73,74,75,76]. There are few or no randomized, controlled published trials that evaluate the effectiveness of the INSs flunisolide, triamcinolone, or beclomethasone in polyposis [77].…”

Section: Resultsmentioning

confidence: 99%

“…There are few or no randomized, controlled published trials that evaluate the effectiveness of the INSs flunisolide, triamcinolone, or beclomethasone in polyposis [77]. Two studies with beclomethasone from the 1970s showed significant symptom improvement, but they were likely too short in duration (3 and 4 weeks) to show effects on polyp size [64,65]. …”

Section: Resultsmentioning

confidence: 99%

Evidence-Based Management of Nasal Polyposis by Intranasal Corticosteroids: From the Cause to the Clinic

Bachert¹

2011

Int Arch Allergy Immunol

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Background: Nasal polyposis is an inflammatory disorder involving the mucosa of the nose and paranasal sinuses and affecting approximately 2–4% of the general population. Methods: A literature search of Medline and Embase was conducted to obtain an overview of the epidemiology, pathophysiology, and current treatment of nasal polyposis, focusing on evidence-based efficacy of intranasal corticosteroids (INSs) as primary and postoperative therapy. Recent research on INSs in nasal polyp treatment, along with notable historic findings, was reviewed. Results: Nasal polyps are mostly characterized by eosinophil infiltration, a complex inflammation of nasal mucosa, and possibly production of polyclonal IgE. Current treatment modalities include INSs, oral corticosteroids, and surgery; surgery is generally limited to those with an insufficient response to medical treatment. Because of their effects on eosinophil-dominated inflammation, INSs and oral corticosteroids are the primary medical treatment strategies. The very low (≤1%) systemic bioavailability of newer INSs minimizes the systemic adverse effects seen with oral corticosteroids. Conclusion:Based on randomized, controlled trials, guidelines recommend INSs as first-line therapy for nasal polyps and for care after polypectomy. Clinical data suggest INSs are effective in reducing polyp size and relieving nasal symptoms. INS treatment has also reduced nasal polyp recurrence in patients undergoing functional endoscopic sinus surgery. Treatment with these mainstay options has been found to improve quality of life, which, along with symptom improvement, is a key factor in disease treatment.

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Treatment of nasal polyps with intranasal beclomethasone dipropionate aerosol

Cited by 100 publications

References 4 publications

The So-Called ‘Allergic’ Nasal Polyp

The So-Called ‘Allergic’ Nasal Polyp

Glucocorticosteroids and rhinitis

Evidence-Based Management of Nasal Polyposis by Intranasal Corticosteroids: From the Cause to the Clinic

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