Treatment of Neonatal Graves' Disease with Sodium Ipodate

Joshi, Renu; Kulin, Howard E.

doi:10.1177/000992289303200314

Cited by 7 publications

(1 citation statement)

References 12 publications

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“…These may or may not reach normal values with nadir reductions of 31% to 65% in 1 to 2 weeks. These drugs have been used effectively in both adult and neonatal Graves' disease (10,11,31,(52)(53)(54), as part of a preoperative regimen for thyroidectomy (55)(56)(57), in destruction-induced thyroiditis (12,32), and in massive levothyroxine overdose (49,50). Escape from inhibition occurs after 2 to 12 weeks when these agents are used as sole therapy (5,6,9,58).…”

Section: Clinical Usementioning

confidence: 99%

The Use of Oral Radiographic Contrast Agents in the Management of Hyperthyroidism

Fontanilla

Schneider²,

Sarne³

2001

Thyroid

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Oral iodinated radiographic contrast agents such as ipodate and iopanoic acid form an important part of the armamentarium used to treat hyperthyroidism. They rapidly and dramatically reduce serum triiodothyronine (T3) levels by inhibiting conversion of thyroxine (T4) to T3 in the periphery and by blocking secretion from the thyroid. Potential risks from the large iodine load resulting from their use limit their widespread applicability. In addition, they are ineffective when used alone on a long-term basis. However, these agents may be especially useful in treating thyrotoxic patients preoperatively, in neonatal Graves' disease, in massive levothyroxine ingestion, and when other conventional antithyroid drugs are unsuccessful or contraindicated.

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