Treatment of neuroblastoma with intraspinal extensions

Thoracic neuroblastic tumors in childhood

“…Thoracic NBTs may present with findings of spinal cord compression and it is known that NBT is the most frequent malignant cause of spinal cord compression in childhood 21. In these cases, laminectomy and/or radiotherapy lead to complications in the long‐term.…”

Treatment and outcome of neuroblastoma with intraspinal extension: A systematic review

“…to 100%. 1,10,34,35,41,46,48,50,51 The severity of the motor deficit at diagnosis was reported in 15 studies. 1,8,10,11,34,37,41,42,[46][47][48][49][50][51]53 The symptom to diagnosis interval, reported as a mean or median, showed considerable variation, ranging from 3 days to 2 months (median 25.5 days).…”

“…1,10,34,35,41,46,48,50,51 The severity of the motor deficit at diagnosis was reported in 15 studies. 1,8,10,11,34,37,41,42,[46][47][48][49][50][51]53 The symptom to diagnosis interval, reported as a mean or median, showed considerable variation, ranging from 3 days to 2 months (median 25.5 days). 1,8,10,11,[33][34][35]37,[46][47][48][49][50][51]53 Nineteen studies reported on the prevalence of neurological motor deficit at the end of follow-up, which ranged from 17 to 69% (median 50%).…”

“…1,8,10,11,34,37,41,42,[46][47][48][49][50][51]53 The symptom to diagnosis interval, reported as a mean or median, showed considerable variation, ranging from 3 days to 2 months (median 25.5 days). 1,8,10,11,[33][34][35]37,[46][47][48][49][50][51]53 Nineteen studies reported on the prevalence of neurological motor deficit at the end of follow-up, which ranged from 17 to 69% (median 50%). 1,8,10,11,[33][34][35][36][37]40,41,[46][47][48][50][51][52][53] Fourteen studies described the severity of the motor deficit at this time point.…”

“…1,8,10,11,[33][34][35][36][37]40,41,[46][47][48][50][51][52][53] Fourteen studies described the severity of the motor deficit at this time point. 1,8,10,11,[33][34][35]41,[46][47][48]50,51,53 Because of lack of uniformity in classification criteria, a comparison between the studies was not possible.…”