Treatment of Non-melanoma Skin Cancers in the Absence of Mohs Micrographic Surgery

Ferry, Andrew M.; Sarrami, Shayan M.; Hollier, Pierce C.; Gerich, Caitlin F.; Thornton, James F.

doi:10.1097/gox.0000000000003300

Cited by 22 publications

(21 citation statements)

References 55 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…31 Independent of the zone(s) that are affected, locoregional tissue transfer and skin grafting techniques are the primary reconstructive options used when correcting partial thickness defects. 2,[32][33][34] Biologic wound agents are also a part of the reconstructive approach to partial thickness cheek defects; however, their use is limited to certain clinical scenarios (►Fig. 6).…”

Section: Cheek Reconstructionmentioning

confidence: 99%

Use of Biologic Agents for Lip and Cheek Reconstruction

et al. 2022

Self Cite

View full text Add to dashboard Cite

The unique requirements of reconstructing cheek defects, often with its proximity to the mobile elements of the face including the lip and the eyelid, have been met very handily with the directed and thoughtful use of biologic wound healing agents. One of the key advantages of these agents is their ability to provide coverage for the mobile elements of the cheek and the lip in patients with multiple co-morbidities. These agents are successfully used where the standard cheek closure techniques including cervicofacial advancement flap are contraindicated due to its anesthetic requirement. Additionally, lip reconstruction involves examining the lip's three anatomic layers: mucosa, muscle, and skin. The defects must be planned for reconstruction based on the involvement of these layers. This paper serves to introduce the use of biologic wound healing agents depending on the involvement of these layers. The authors provide specific illustrations of these agents based on defect location, tissue involvement, and severity of the defect to help with procedural planning to reconstruct a very aesthetically involved part of the face.

show abstract

Section: Cheek Reconstructionmentioning

confidence: 99%

Use of Biologic Agents for Lip and Cheek Reconstruction

et al. 2022

Self Cite

View full text Add to dashboard Cite

show abstract

“…31 Independent of the zone(s) that are affected, locoregional tissue transfer and skin grafting techniques are the primary reconstructive options used when correcting partial thickness defects. 2 32 33 34 Biologic wound agents are also a part of the reconstructive approach to partial thickness cheek defects; however, their use is limited to certain clinical scenarios ( Fig. 6 ).…”

Section: Cheek Reconstructionmentioning

confidence: 99%

“…1 Even though most skin cancers exhibit limited metastatic potential and have a favorable prognosis, all histological subtypes can be locally destructive necessitating extensive surgical resection. 2 3 Plastic surgeons are frequently tasked with reconstructing postablative defects of the cheeks and lips given the aesthetically sensitive nature of these facial structures. Furthermore, these regions play a pivotal role in one's ability to perform multiple vital functions including interpersonal communication and the consumption of solids and liquids.…”

mentioning

confidence: 99%

Use of Biologic Agents for Lip and Cheek Reconstruction

Depani

Thornton

2021

Semin Plast Surg

Self Cite

View full text Add to dashboard Cite

The unique requirements of reconstructing cheek defects, often with its proximity to the mobile elements of the face including the lip and the eyelid, have been met very handily with the directed and thoughtful use of biologic wound healing agents. One of the key advantages of these agents is their ability to provide coverage in patients with multiple comorbid conditions for the mobile elements of the cheek where the cervicofacial advancement flap is contraindicated due to its anesthetic requirement. The biologic agents are also highly successful coverage options for patients who have limited skin laxity to provide for proper skin closure using the standard cheek closure techniques with local flaps. In addition, these agents provide an ability to provide stable wound closure with minimal wound care while waiting for the excisional biopsy results to be finalized. This article describes the unique indications for biologic wound agents, including preservation of lip and eyelid mobile element anatomy without retraction from a local flap, which has not been previously described.

show abstract

“…Liquid nitrogen cryotherapy is one of the common cryotherapy methods for the treatment of cSCC. However, it is more widely used for malignant tumors with superficial location, small diameter (less than 2 cm), and low metastatic risk (4,19,20). In this study, the argon-helium cryoablation was used for the treatments of elderly cSCC patients with large tumor sizes.…”

Section: Discussionmentioning

confidence: 99%

Argon–Helium Cryoablation for Cutaneous Squamous Cell Carcinoma in the Elderly

Huang¹,

Xu²

2022

Front. Oncol.

View full text Add to dashboard Cite

Cutaneous squamous cell carcinoma (cSCC) is a common type of malignant neoplasm in non-melanoma skin cancer (NMSC). Most cases of simple cSCC are considered curable by surgical removal of the lesion. However, clinical treatments for cSCC with medium- or large-sized lesions are difficult. Meanwhile, the effectiveness of the treatments is not guaranteed, especially for elderly patients, because of an intolerance to surgical resection or other adjuvant modalities. In such cases, safe and effective treatments with excellent aesthetic outcomes are urgently needed. In this study, we reported 6 elderly cSCC patients with medium- or large-sized lesions treated with argon–helium cryoablation. The average age of all 6 patients was 78 years (range 72–85 years). They were all diagnosed with cSCC with a median tumor size of 5.8 cm (range 2.5–15.5 cm) and dermal invasion. Complete ablation was achieved in all cases after a single ablation session (2 freeze–thaw cycles). Patients experienced mild pain and hemorrhage after ablation, but the symptoms were manageable. One patient developed infection and fever because of extensive necrosis of the tumor, which was eventually cured after treatment. All patients obtained good cosmetic outcomes, and their quality of life improved significantly. In the 5-year follow-up study, 4 patients were alive while 2 patients died of unrelated diseases 3 years after cryotherapy. None of the 6 patients had a recurrence. These results suggested the feasibility of argon–helium cryoablation as a novel therapeutic strategy for elderly cSCC with medium- or large-sized lesions.

show abstract

Treatment of Non-melanoma Skin Cancers in the Absence of Mohs Micrographic Surgery

Cited by 22 publications

References 55 publications

Use of Biologic Agents for Lip and Cheek Reconstruction

Use of Biologic Agents for Lip and Cheek Reconstruction

Use of Biologic Agents for Lip and Cheek Reconstruction

Argon–Helium Cryoablation for Cutaneous Squamous Cell Carcinoma in the Elderly

Contact Info

Product

Resources

About