Treatment of odontogenic abscesses: comparison of primary and secondary removal of the odontogenic focus and antibiotic therapy

Baum, Sven Holger; Ha-Phuoc, A.-K.; Mohr, Christopher

doi:10.1007/s10006-020-00835-w

Cited by 9 publications

(5 citation statements)

References 31 publications

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“…Thus, our results raise the question of when a tooth extraction alone is insufficient as treatment for OI or if infection spread is not identified at a sufficiently early stage. On the other hand, even though prompt OI care is known to require simultaneous tooth extraction [23,37], it is often not made in time [21]. In addition, the extraction itself may in some cases predispose the patient to infection spread.…”

Section: Discussionmentioning

confidence: 99%

Health status in patients hospitalised for severe odontogenic infections

Furuholm

Rautaporras

Uittamo

et al. 2021

Acta Odontologica Scandinavica

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Objective: Previous findings refer to certain predisposing medical conditions that compound the risk of developing severe and potentially lethal acute odontogenic infections (OI). The objective of this study was to clarify this rationale and infection severity in general. Material and methods: Records of patients aged !18 years requiring hospital care for deep OI were retrospectively investigated. The main outcome variable was need for intensive care unit (ICU) treatment. Additional outcome variable was occurrence of infection complications and/or distant infections. Several parameters describing patients' prior health and recent dental treatment were set as independent variables. Results: Of the 303 acute OI patients included, 71 patients (23%) required treatment in the ICU, with no significant difference between previously healthy and patients with disease history. OIs originating from teeth in the mandible compared with maxilla had 7.8-fold risk (p ¼ .007) for ICU treatment in binary logistic regression analyses. Elevated levels of infection parameters at hospital admission predicted further ICU stay. Infection complications and/or distant infections occurred in 7.6% of patients, of which septicaemia and pneumonia were the most common. The mortality rate was 0.3%. Infection complications and/or distant infections occurred significantly more often in smokers (p ¼ .001) and in patients with excessive consumption of alcohol or drugs (p ¼ .025), however smoking showed 3.5folded independent risk for infection complications and/or distant infections (p ¼ .008) in logistic regression. Conclusions: Severe OIs often occur in previously healthy patients. Smokers in particular are prone to the most serious OIs.

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Section: Discussionmentioning

confidence: 99%

Health status in patients hospitalised for severe odontogenic infections

Furuholm

Rautaporras

Uittamo

et al. 2021

Acta Odontologica Scandinavica

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“…The identified RCTs could not be included in the systematic review either because the Narrative review on effectiveness of antibiotics in pericoronitis outcomes were not separately reported for endodontic and periodontal abscesses (or pericoronitis) [27][28][29][30][31], because the efficacy of two antibiotics was compared with each other in the absence of a placebo or control group [27,28,30,[32][33][34][35][36], or because no separate outcomes were provided for patients in whom antibiotics were used as a single treatment versus patients in whom antibiotics were used as adjunctive treatment (Table 5) [27,28]. Very recently, two retrospective cohort studies were published, but they were both restricted to hospitalised patients (while the focus of this systematic review was on patients treated in the ambulatory setting) and not limited to periodontal abscesses, but most importantly, there was no control group, so they could not provide an answer to our research question either (Table 6) [37,38]. Comparable concerns apply to the older studies published by Taani [39], Hafström et al [40], Sasaki [41], and Smith and Davies [42].…”

Section: Discussionmentioning

confidence: 99%

Should systemic antibiotics be prescribed in periodontal abscesses and pericoronitis? A systematic review of the literature

Leroy

Bourgeois

Verleye

et al. 2022

European J Oral Sciences

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This study assessed whether systemic antibiotics are beneficial or harmful in patients who present with an acute periodontal abscess or pericoronitis, with or without systemic involvement, and, if antibiotics are beneficial, which type, dosage, and duration are the most effective. Medline, Embase, and the Cochrane Library were screened from 1948 up to 1 April 2022 for systematic reviews, randomised clinical trials (RCTs), and other studies. Dedicated websites were consulted for systematic reviews, clinical practice guidelines, and health technology assessments on the topic. Outcomes of interest comprised tooth survival, swelling, pain, tooth mobility, periodontal probing depth, suppuration, adverse effects, quality of life measurements, and medication required for pain relief. Overall, five guidelines, seven systematic reviews, 15 RCTs, and 34 other studies were identified and selected for full-text assessment, but none of them fulfilled the inclusion criteria. At present there is no single randomised or non-randomised controlled trial assessing the harms and clinical effectiveness of systemic antibiotics in adults with a periodontal abscess or pericoronitis.

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“…Since their discovery, antibiotics have become essential in successfully combating infectious diseases to improve human health [1,2]. In dentistry, antibiotics are selectively used for orofacial infections of odontogenic and non-odontogenic origins such as dental abscess, pulpal necrosis, periodontal diseases, dental caries, dental trauma, adenoiditis, otomastoiditis, and in prophylaxis [2][3][4][5]. Penicillin beta-lactam and amoxicillin, along with clindamycin, are the most widely prescribed oral antibiotic agents in dentistry, prophylactically and for therapeutic use, for their broad-spectrum antimicrobial activity of the former and as an alternate to penicillin allergic responses for the latter [1,6,7].…”

Section: Introductionmentioning

confidence: 99%

Potential Synergistic Inhibition of Enterococcus faecalis by Essential Oils and Antibiotics

John,

Lee,

Lamichhane

et al. 2023

Applied Sciences

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Recurrent infections after root canal treatments often involve Enterococcus faecalis, a microorganism closely associated with therapy failures due to its biofilm production, survival in nutrient-deprived conditions, and antibiotic tolerance. Essential oils (EOs), which display antimicrobial and antibacterial properties, exhibit inhibitory effects on the growth of many microorganisms including E. faecalis. This study assessed the in vitro efficacy of combining 5% antibiotics (kanamycin 2.5 mg/mL, streptomycin 2.5 mg/mL, gentamicin 1.5 mg/mL, and ampicillin 5 mg/mL) with cinnamon (1.25% to 5%) or clove (25% and 50%) EOs in inhibiting the growth of E. faecalis, using disk diffusion tests. Disks were treated with EOs-only, antibiotics-only, or EO–antibiotic combinations, placed on BEA agar plates, and incubated for 24 h, and the zones of inhibition were measured. Results showed that EOs (cinnamon and clove) and 5% antibiotics, by themselves, had robust growth inhibition of E. faecalis across all tested concentrations. Moreover, combining 5% aminoglycosides (kanamycin 2.5 mg/mL, streptomycin 2.5 mg/mL, and gentamicin 1.5 mg/mL) with 5% cinnamon EO produced significantly enhanced antimicrobial effect than the corresponding 10% antibiotic solution alone. These findings suggest that combining cinnamon EO with aminoglycoside antibiotics can achieve significant inhibition of E. faecalis at a lower concentration of antibiotics compared to using a higher dose of antibiotics alone. Further in vivo studies should determine the safety, efficacy, and treatment duration, with the potential to reduce antibiotic dosages and associated toxicity while preventing recurrent infections.

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Treatment of odontogenic abscesses: comparison of primary and secondary removal of the odontogenic focus and antibiotic therapy

Cited by 9 publications

References 31 publications

Health status in patients hospitalised for severe odontogenic infections

Health status in patients hospitalised for severe odontogenic infections

Should systemic antibiotics be prescribed in periodontal abscesses and pericoronitis? A systematic review of the literature

Potential Synergistic Inhibition of Enterococcus faecalis by Essential Oils and Antibiotics

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