Treatment of Odontogenic Phlegmons in Patients Taking Into Account the Biorithm of Life

Аветіков, Давид Соломонович; Lychman, V. O.; Локес, Катерина Петрівна; Steblovsky, Dmitriy V; Bondarenko, V.V.; Shlykova, O. A.

doi:10.36740/wlek202106111

Cited by 19 publications

(11 citation statements)

References 16 publications

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“…Позитивні результати щодо нормалізації імунологічної реактивності організму пацієнта було доведено за умов використання препаратів групи адаптогенів, які мають імуномодулюючу (нормалізуючу) дію незалежно від типу реагування організму на інфекційний процес [5,6]. Добре себе зарекомендувало використання антиоксидантів з метою Актуальні проблеми сучасної медицини корекції метаболічних порушень та підвищення антиоксидантного захисту організму, яке обумовлено підвищеним рівень вільно-радикального окислення за умов гнійно-запальних процесів [7].…”

Section: вступunclassified

Processes of Free Radical Oxidation in Therapy for Patients With Odontogenic Phlegmons in Maxillo-Facial Area in the Presence of Ischemic Heart Disease

Kiptilyi,

Yatsenko,

Lychman

et al. 2023

Act. Probl. of the Modern Med.

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A large cohort of scientists is dealing with the issue of improving the treatment of maxillofacial odontogenic phlegmons. The course of these diseases is impacted by a significant number of factors, one of which is ishemic heart disease. Quercetin is a powerful antioxidant with a pronounced antioxidant effect. The use of 2-ethyl-6-methyl-3-hydroxypyridine succinate leads to increased oxidation of components, that is, to a synergistic antioxidant effect. The purpose of this study is to enhance the therapy of odontogenic phlegmons of maxillofacial area in patients with ishemic heart disease through the combined use of drugs with antioxidant, antihypoxant and angioprotective effects. Materials and methods. 80 patients with odontogenic phlegmon of maxillofacial area were examined. The participants were categorized into the following groups: Group 1 received parenteral quercetin, Group 2 received a combination of quercetin and intravenous administration of 2-ethyl-6-methyl-3-hydroxypyridine succinate, Group 3 received standard treatment (20 individuals), and Group 4 (control) comprised individuals without concomitant pathology who received the treatment according to a standard protocol (20 patients). To analyze the state of free radical oxidation processes in blood serum, the content of diene conjugates was studied. Results. The level of diene conjugates was increased when compared to the control group by 93.2%, 95.0% and 96.2% for the 1st, 2nd and 3rd clinical groups, respectively. On the third day of observation, patients with coronary heart disease displayed an increase in the studied indicator by 99.1%, 100.6%, and 97.8%, respectively, compared to the controls. After 5 days, in all four clinical groups, there was a decrease in diene conjugates content in blood serum compared to the previous observation period by 6.9%, 8.2%, 5.3% and 11.8%, respectively. A tendency to a gradual decrease in the content of diene conjugates was observed on the 7th day of observation in all groups by 5.5%, 6.8%, 4.2% and 11.8%, respectively, with its increase relative to the control by 112.9 %, 108.7% and 118.2% for the 1st, 2nd and 3rd clinical groups, respectively. On the 9th day of observation, a decrease in DC content by 2.7% was found only in patients of the 2nd clinical group. At the final follow-up period, a decrease in this marker was noted in all studied clinical groups relative to the previous follow-up period by 5.1%, 6.9%, 2.3%, and 9.7%, respectively. Conclusion: Under the combined administration of quercetin and 2-ethyl-6-methyl-3-hydroxypyridine succinate alongside a standard treatment protocol, the reduction in the level of diene conjugates in blood serum was most significant among patients with coronary heart disease, particularly in the later stages following surgical treatment.

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Section: вступunclassified

Processes of Free Radical Oxidation in Therapy for Patients With Odontogenic Phlegmons in Maxillo-Facial Area in the Presence of Ischemic Heart Disease

Kiptilyi,

Yatsenko,

Lychman

et al. 2023

Act. Probl. of the Modern Med.

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“…В результаті у цих пацієнтів були порушені процеси регенерації, змінені терміни перебігу фаз ранового процесу, загоєння ран подовжувалося в 2-3 рази (зокрема, при компенсованому ЦД терміни утворення грануляційної тканини та рубця збільшувалися в 1,5-2 рази, а при некомпенсованому діабеті -навіть у 2,5 рази), у хворих середньою та тяжкою формою діабету, як правило, спостерігалося ускладнене протягом післяопераційного періоду. Аналогічні дані наводять інші автори [1,3].…”

Section: методика дослідженняunclassified

“…Мінімізацію появи рубців на обличчі та оптимізацію косметичного результату ідеально починати до ушивання рани або, у випадку травми, під час первинної обробки рани. Навіть якщо початкове загоєння було незадовільним, зовнішній вигляд рубця можна покращити в післяопераційний період [2,3]. З попередніх досліджень доведено, що на формування післяопераційного рубця впливає також і хронотип людини [4], який відіграє фундаментальну роль у регуляції біологіч-них функцій, температури тіла, гормональну секрецію, споживання їжі, а також когнітивну та фізичну працездатність [5].…”

Section: вступunclassified

“…На наш погляд, важкі наслідки у цих хворих на попередніх етапах лікування були зумовлені взаємозв'язком погано лікованої гнійної інфекції з некомпенсованим ЦД. Це і є основа синдрому «взаємного обтяження», що означає нову форму захворювання зі специфічною несприятливою течією, яка вимагає, на нашу думку, принципово нового підходу до лікування [2,3,4,5,6].…”

unclassified

“…Підвищену сприйнятливість до інфекцій у пацієнтів з ЦД пов'язують з порушеннями захисних функцій імунної системи, посиленням клітинної адгезії мікроорганізмів, наявністю мікро-та макроангіопатії, нейропатії, а також підвищеною частотою консервативних і хірургічних втручань [3,7].…”

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Modern Conception of Treating Purulent Inflammatory Diseases of Face and Neck in Patients With Diabetes Mellitus

Steblovskiy¹

2022

Act. Probl. of the Modern Med.

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The issue of surgical treatment of purulent infection in people suffering from diabetes mellitus is becoming increasingly important that can be explained by a significant growth of diabetes worldwide. The combination of diabetes mellitus and surgical infection forms a closed vicious circle, in which the infection negatively affects metabolic processes, increasing insulin insufficiency and acidosis, while metabolic and microcirculation disorders worsen the course of reparative processes in the lesion. A lack of insulin in patients with diabetes mellitus results in the disorganization of carbohydrate metabolism that is manifested by hyperglycemia, glycosuria, a decrease in the content of glycogen in tissues and, first of all, in the liver. Liver dysfunction, in turn, leads to water-salt and protein metabolisms changes. The impairment of protein metabolism is manifested in a decrease in its synthesis and an increase in its breakdown. As a result, the formation of glucose from amino acids becomes more intensive. The accumulation of ketone bodies and acetone under an almost complete inability to synthesize fats leads to ketoacidosis. The goal of this work is to analyze the treatment outcomes of patients with diabetes mellitus who had various purulent and inflammatory diseases of the maxillofacial area. The treatment of purulent wounds in the patients with diabetes mellitus requires the participation of an endocrinologist to control criteria, which can objectively reflect the course of the wound healing including cytological examination of wound impressions, morphological examination of wound tissues, determination of indicators of tissue homeostasis in the lesion. The use of the methods described above, as well as the scope and direction of therapy in each specific case should be based on the teach approach to this comorbidity. Noteworthy, the course of purulent and inflammatory diseases of the maxillofacial area under diabetes mellitus is peculiar and atypical, often leading to the development of formidable complications and even death. Effective treatment of foci of inflammation under decompensated diabetes is a hard task. Special attention should be paid to the study of the etiopathogenetic mechanisms of the development of purulent-inflammatory diseases of the maxillofacial area in patients with diabetes mellitus and to the development of new treatment algorithms. Close cooperation of maxillofacial surgeons and endocrinologists will help preserve life quality and life expectance of the patients with diabetes mellitus.

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Expression of periferal core molecular clock genes in oral mucosa depends on the chronotype in patients with maxillofacial cellulitis

Локес

Lychman

Izmailova

et al. 2023

Journal of Oral Biology and Craniofacial Research

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Treatment of Odontogenic Phlegmons in Patients Taking Into Account the Biorithm of Life

Cited by 19 publications

References 16 publications

Processes of Free Radical Oxidation in Therapy for Patients With Odontogenic Phlegmons in Maxillo-Facial Area in the Presence of Ischemic Heart Disease

Processes of Free Radical Oxidation in Therapy for Patients With Odontogenic Phlegmons in Maxillo-Facial Area in the Presence of Ischemic Heart Disease

Modern Conception of Treating Purulent Inflammatory Diseases of Face and Neck in Patients With Diabetes Mellitus

Expression of periferal core molecular clock genes in oral mucosa depends on the chronotype in patients with maxillofacial cellulitis

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