Treatment of Oligospermia with the Amino Acid Arginine

Schachter, A; Friedman, Shmuel; Goldman, Jack A.; Eckerling, B

doi:10.1002/j.1879-3479.1973.tb00901.x

Cited by 20 publications

(8 citation statements)

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“…L-Arginine is known to increase spermatogenesis and acts as a source of energy for normal sperm motility in the form of arginine phosphoric acid. Schachter et al (1973) have suggested that a deficiency in L-arginine due to poor diet, improper absorption, or abnormally active decomposition causes a subsequent derangement of metabolism in tissues undergoing frequent mitosis. Other reports (Bernard, 1967;Tanimura, 1967;Keller and Polakoski, 1975;Jungling and Bunge, 1976) describe a correlation between L-arginine deficiency and loss of spermatogenesis and a decrease in the motility of the sperm cells.…”

Section: Introductionmentioning

confidence: 99%

Arginine Activates Glycolysis of Goat Epididymal Spermatozoa: An NMR Study

Patel

Srivastava

Phadke

et al. 1998

Biophysical Journal

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The present study explores the mechanism underlying the action of L-arginine on the metabolic activity of spermatozoa. Goat epididymal spermatozoa were incubated with different concentrations of L-arginine to determine its effect on the utilization of glucose, fructose, and pyruvate. NMR techniques have been applied to elucidate the effect of L-arginine, L-lysine, and L-ornithine on the glycolysis of epididymal goat spermatozoa. Whereas 31P NMR has been used to estimate the change of pH in the presence of different concentrations of L-arginine, 13C NMR has been used to estimate the substrate consumption and lactate production. At optimal concentration of L-arginine, the forward metabolic rates have been found to increase by two to three times over control experiments. Arginine is not consumed in these reactions, but acts as an activator. Longitudinal relaxation time (T1) measurements indicate that the guanidino group of L-arginine plays an active role in binding to cells. The amino acid L-lysine is less effective, and L-ornithine is ineffective.

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Section: Introductionmentioning

confidence: 99%

Arginine Activates Glycolysis of Goat Epididymal Spermatozoa: An NMR Study

Patel

Srivastava

Phadke

et al. 1998

Biophysical Journal

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“…These molecules act as chelating agents (especially of toxic metals), serve as oxidizable substrates for spermatozoa, provide buffers with protective influence on sperm cells, and undergo further metabolic changes in semen under the influence of transaminases and deaminases. Our results indicating the presence of arginine in goat cauda EF are highly implicated in its effect, in particular, stimulation of mammalian sperm motility in vitro (27)(28)(29), and in its beneficial effect on the sperm count for oligospermic semen after massive oral doses (30,31).…”

Section: Discussionmentioning

confidence: 89%

Identification of Low-Molecular-Weight Compounds in Goat Epididymis Using Multinuclear Nuclear Magnetic Resonance

Patel

Srivastava

Phadke

et al. 1999

Analytical Biochemistry

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“…L-Arginine is of critical importance for normal spermatogenesis and maintenance of in vivo sperm motility [7,9,121. L-arginine also stimulates the motility of ejaculated human sperm in vitro in a concentration dependent manner [6].…”

Section: Introductionmentioning

confidence: 99%

Arginine Induced Stimulation of Rabbit Sperm Motility

Radany

Atherton

1981

Archives of Andrology

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L-Arginine stimulation of ejaculated rabbit sperm motility was quantitated by a spectrophotometric procedure. Stimulation of sperm motility was correlated to arginine concentration, incubation time, and pH. A maximum increase in motility of 85% was apparent for up to 7 hr with 10(-1) M L-arginine. A significant decrease in the ability of L-arginine to stimulate sperm motility was observed at pH values less than 7.0 and greater than 8.0. The percent stimulation was inversely proportional to the initial motility of the sperm sample.

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Treatment of Oligospermia with the Amino Acid Arginine

Cited by 20 publications

References 1 publication

Arginine Activates Glycolysis of Goat Epididymal Spermatozoa: An NMR Study

Arginine Activates Glycolysis of Goat Epididymal Spermatozoa: An NMR Study

Identification of Low-Molecular-Weight Compounds in Goat Epididymis Using Multinuclear Nuclear Magnetic Resonance

Arginine Induced Stimulation of Rabbit Sperm Motility

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