Treatment of Oral Lichen Sclerosus with 1% Pimecrolimus Cream

Kim, Chi Yeon; Kim, Jin Gu; Oh, Chang Wug

doi:10.5021/ad.2010.22.3.326

Cited by 16 publications

(14 citation statements)

References 10 publications

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“…Kim et al [108] recently added an oral case of LS in a 7-year-old girl successfully treated with pimecrolimus cream 1 % twice daily for 8 weeks. After unsatisfactory treatment with ultrapotent topical corticosteroids, the lesion improved within 4 weeks of treatment with pimecrolimus and disappeared after 12 weeks.…”

Section: Treatmentmentioning

confidence: 99%

Diagnosis and Treatment of Lichen Sclerosus

2012

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Lichen sclerosus (LS) is a chronic, inflammatory, mucocutaneous disorder of genital and extragenital skin. LS is a debilitating disease, causing itch, pain, dysuria and restriction of micturition, dyspareunia, and significant sexual dysfunction in women and men. Many findings obtained in recent years point more and more towards an autoimmune-induced disease in genetically predisposed patients and further away from an important impact of hormonal factors. Preceding infections may play a provocative part. The role for Borrelia is still controversial. Trauma and an occlusive moist environment may act as precipitating factors. Potent and ultrapotent topical corticosteroids still head the therapeutic armamentarium. Topical calcineurin inhibitors are discussed as alternatives in the treatment of LS in patients who have failed therapy with ultrapotent corticosteroids, or who have a contraindication for the use of corticosteroids. Topical and systemic retinoids may be useful in selected cases. Phototherapy for extragenital LS and photodynamic therapy for genital LS may be therapeutic options in rare cases refractory to the already mentioned treatment. Surgery is restricted to scarring processes leading to functional impairment. In men, circumcision is effective in the majority of cases, but recurrences are well described. Anogenital LS is associated with an increased risk for squamous cell carcinoma of the vulva or penis. This review updates the epidemiology, clinical presentation, histopathology, pathogenesis, and management of LS of the female and male genitals and extragenital LS in adults and children.

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Section: Treatmentmentioning

confidence: 99%

Diagnosis and Treatment of Lichen Sclerosus

2012

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“…IF examination of biopsy was performed in four cases, and only the present case 1 first showed positive findings: linear IgG, IgM, and fibrin deposits at the basement membrane suggesting pemphigoid. However, the second IF examination 13 months later yielded negative results.…”

Section: Discussionmentioning

confidence: 61%

“…In addition, several major histocompatibility complex genes occur more often in LS patients than in controls. 31,32,[35][36][37][38][39][40] IF examination of biopsy was performed in four cases, 12,14,41 and only the present case 1 first showed positive findings: linear IgG, IgM, and fibrin deposits at the basement membrane suggesting pemphigoid. However, the second IF examination 13 months later yielded negative results.…”

Section: Ols Patients Are Often Older Than Oral Submucosis Fibrosismentioning

confidence: 99%

Oral lichen sclerosus: a systematic review of reported cases and two new cases

2018

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Lichen sclerosus (LS) is a chronic inflammatory mucocutaneous disease with uncertain etiology. It occurs as white plaque-like lesions mostly in the anogenital skin. Oral mucosal involvement is extremely rare. This study aims to summarize the features of published oral lichen sclerosus (OLS) and two new cases. A systematic search of the English literature from 1955 to 2016 was performed in MEDLINE, Scopus, and Web of Science, and cross-references were searched manually. Search phrases included "lichen sclerosus," "mouth," "oral," "lip," "palate," "floor of mouth," "tongue," "gingiva," "buccal mucosa," and "mouth diseases." Cases with clinical and histopathological confirmation of diagnosis of OLS were included. A total of 41 (39 published and 2 new) histologically confirmed OLS cases were available. The median age of OLS patients was 31 years, and 66% of the patients were female. Most of the OLS lesions were asymptomatic. They were located in the labial mucosa (n = 20), lip (n = 15), buccal mucosa (n = 14), gingiva (n = 12), tongue (n = 12), and palate (n = 7). OLS is rare and typically presents as asymptomatic, white, plaque-like lesions. Malignant transformation of preexisting OLS has not been reported.

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“…Clinically, it presents as white, sometimes painful, pruritic papules or plaques. Despite its predilection for the anogenital regions the condition can occur throughout the body, although lesions of the oral mucosa are exceedingly rare and those involving the gingiva are even more so . In the oral mucosa LS is seen typically in middle‐aged females, the most common sites being the lower lip, buccal mucosa and upper lip .…”

mentioning

confidence: 99%

“…Histologically, LS is characterized by an atrophic thinned epidermis with blunted rete ridges, hydropic degeneration of the basal layer, and dermal collagen sclerosis with an underlying band of lymphocytic infiltrate. These features tend to overlap in both skin and oral mucosal lesions …”

mentioning

confidence: 99%