Treatment of Oral Mucositis Using Platelet-Rich-Fibrin: A Retrospective Study on Oncological Patients

Miranda, Michele; Gianfreda, Francesco; Rosa, Ariádene Cristina Pértile de Oliveira; Fiorillo, Luca; Cervino, Gabriele; Cicciù, Marco; Bollero, Patrizio

doi:10.1097/scs.0000000000009450

Journal of Craniofacial Surgery

2023

DOI: 10.1097/scs.0000000000009450

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Treatment of Oral Mucositis Using Platelet-Rich-Fibrin: A Retrospective Study on Oncological Patients

Michele Miranda

Francesco Gianfreda

Ariádene Cristina Pértile de Oliveira Rosa

et al.

Abstract: Oral mucositis is an inflammatory mucosal demolition frequently observed during treatments for neoplastic diseases such as chemotherapy or radiation therapy. The side effects of these treatments often drastically reduce patients’ quality of life. Oral mucositis is the result of the systemic consequences of chemotherapy and radiotherapy, which due to their cytotoxic and local effects, lead to pain and severe ulceration with a consequent decrease in the quality of life of affected subjects. Plasma rich in fibrin… Show more

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Cited by 3 publications

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Comparison of Histological, Clinical, and Radiographic Outcomes of Postextraction Ridge Preservation by Allogenic Bone Grafting With and Without Injectable Platelet‐Rich Fibrin: A Double‐Blinded Randomized Controlled Clinical Trial

Talebi Ardakani,

Rezaei Esfahrood,

Mashhadiabbas

et al. 2024

International Journal of Dentistry

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Objectives: This randomized controlled clinical trial compared the histological, clinical, and radiographic outcomes of postextraction ridge preservation by allogenic bone grafting with and without injectable platelet‐rich fibrin (I‐PRF).Materials and Methods: Twenty single‐rooted maxillary and mandibular teeth to be extracted and replaced by dental implants were randomly divided into two groups (n = 10). Cone‐beam computed tomography (CBCT) scans were obtained preoperatively to assess bone dimensions and ridge width. The teeth were then extracted, and tooth socket preservation was performed with allograft and collagen type 1 in the control group and allograft, collagen type 1, and I‐PRF in the intervention group. CBCT scans were obtained again 3 months after the first stage of surgery, and the second stage of surgery was performed for implant placement, ridge width measurement, and obtaining a biopsy sample. Radiographic bone width, clinical bone width, and radiographic bone height were measured. A histomorphometric method was applied to quantify residual graft material, new bone formation, and nonmineralized tissues. The data were analyzed with Student’s t‐test and Mann–Whitney U test (α = 0.05).Results: The intervention group showed a significantly smaller reduction in radiographic bone width (P = 0.038) and clinical bone width (P = 0.033), reduction in radiographic bone height (P = 0.213) was not significant. A significantly lower percentage of residual graft particles (P = 0.021) and a significantly higher mean percentage of newly formed bone (P = 0.038) than the control group. However, the difference in the percentage of nonmineralized tissue (P = 0.208) was not significant.Conclusion: Despite the optimal outcome of ridge preservation in both groups, the application of allograft plus I‐PRF yielded superior histological, clinical, and radiographic results compared with allograft alone, and this difference was significant in most variables.

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Comparison of Histological, Clinical, and Radiographic Outcomes of Postextraction Ridge Preservation by Allogenic Bone Grafting With and Without Injectable Platelet‐Rich Fibrin: A Double‐Blinded Randomized Controlled Clinical Trial

Talebi Ardakani,

Rezaei Esfahrood,

Mashhadiabbas

et al. 2024

International Journal of Dentistry

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Low-level laser treatment’s ability to reduce dry socket pain

Minervini,

Franco,

Martelli

et al. 2024

AOS

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After a tooth extraction, a dry socket is a common problem that can cause excruciating pain and prevent healing. Antiseptic dressings have historically been the mainstay of treatments for this illness in order to lower bacteria and accelerate healing. Alveogyl is a medicated dressing composed of butamben, iodoform, and eugenol is conventionally used to manage the pain associated with dry socket. The purpose of this study is to assess how well laser therapy treats alveolitis symptoms. The idea that laser therapy is an excellent tool for treating alveolitis is what motivated this meta-analysis. This systematic review aims to evaluate the effects of Level Laser Therapy (LLT) in the treatment of dry socket. Methods: A literature search was done on PubMed, Lilacs, Web of Science, Scopus, and Cochrane using the keywords entered, and papers published between January 2000 and September 2023 were taken into consideration. The terms “laser” and “dry socket” have been merged using the Boolean conjunction AND; the results show that 65 studies could be identified using the three search engines. Only five were selected to create the current systematic study and metanalysis. The meta-analysis demonstrated that laser therapy is superior to the traditional Alvogyl treatment in managing alveolitis symptoms, especially in pain reduction. The overall effect demonstrated a mean difference of −2.01 (95% CI: −2.43 to −1.59) on the third day of treatment, with a p < 0.05, indicating statistical significance. Conclusion: The quantitative analysis showed that Low-Level Laser Therapy demonstrated promising potential in managing alveolitis symptoms, particularly in terms of pain reduction, when compared to traditional treatments like Alvogyl. Despite the results indicating a statistically significant reduction in pain, the evidence does not conclusively establish laser therapy as a complete substitute for conventional therapies. Further high-quality studies with larger sample sizes and standardized protocols are required to confirm its long-term efficacy and to assess its broader applicability in clinical settings.

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Oral Manifestations of Graft vs. Host Disease: A Comprehensive Review for Best Practice in Dentistry

Miranda,

Gianfreda,

Carlotta

et al. 2023

Medicina

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Graft-versus-host disease (GVHD) is a complication of hematopoietic stem cell transplantation (HSCT). GVHD may also develop following solid transplants or blood transfusions if white blood cells are transferred. GVHD affects multiple organs, including the oral tissues. This pictorial review provides a background of GVHD to dental practitioners, describes the most common oral manifestations of GVHD, and highlights the main treatment modifications needed to deliver dental care to patients with GVHD. A narrative review enriched with clinical data was performed by searching the scientific literature for all articles regarding GVHD and oral manifestations/therapies. All articles without exclusion criteria, except animal tests, were included in the above review. Acute GVHD may manifest in the oral mucosa; however, it often develops immediately following HSCT when routine dental treatment is postponed. Chronic GVHD may manifest in the oral mucosa, the salivary glands, and the musculoskeletal compartment. It may indirectly affect the teeth and the oral flora, putting the patient at risk for infections. Importantly, GVHD poses an increased risk for oral cancer. GVHD has a wide range of oral manifestations, some of which may affect dental treatment.

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Treatment of Oral Mucositis Using Platelet-Rich-Fibrin: A Retrospective Study on Oncological Patients

Cited by 3 publications

References 24 publications

Comparison of Histological, Clinical, and Radiographic Outcomes of Postextraction Ridge Preservation by Allogenic Bone Grafting With and Without Injectable Platelet‐Rich Fibrin: A Double‐Blinded Randomized Controlled Clinical Trial

Comparison of Histological, Clinical, and Radiographic Outcomes of Postextraction Ridge Preservation by Allogenic Bone Grafting With and Without Injectable Platelet‐Rich Fibrin: A Double‐Blinded Randomized Controlled Clinical Trial

Low-level laser treatment’s ability to reduce dry socket pain

Oral Manifestations of Graft vs. Host Disease: A Comprehensive Review for Best Practice in Dentistry

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