Treatment of Oral Pemphigus Vulgaris

Chrysomallis, Fotis; Ioannides, Demetris; Teknetzis, A; Panagiotidou, D; Minas, A.

doi:10.1111/j.1365-4362.1994.tb01003.x

Cited by 70 publications

(63 citation statements)

References 24 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Eine bessere Wirksamkeit, insbesondere auf Schleimhautläsionen des PV ist für diese Therapie jedoch nicht belegt. So konnten Chrysomallis et al [8] beim Vergleich zwischen Prednison (40 mg) als Monotherapie und der Kombination aus 40 mg Prednison und verschiedenen Cyclophosphamiddosierungen keinen signifikanten Unterschied zwischen den jeweiligen Gruppen nachweisen. Auch die Kombination von Prednisolon mit Cyclosporin zeigte gegenüber der Monotherapie mit Prednisolon keinen Vorteil [15].…”

Section: Immunsuppressiver Therapieansatzunclassified

Gold

et al. 2007

View full text Add to dashboard Cite

High-dose steroids in combination with other immunosuppressant substances, usually azathioprine, are the therapy of choice in pemphigus vulgaris. Complete remission can be difficult to achieve, with mucosal lesions often recalcitrant. We describe two patients in whom gold in the form of sodium aurothiomalate was effective in resolving mucosal lesions. Initially both patients were treated with high-dose corticosteroids, one in combination with mycophenolate mofetil. Their oral lesions proved to be stubborn but responded well to intramuscular gold, which also showed a steroid-sparing effect, so that the dosage of corticosteroids could be reduced to a minimum. Sodium aurothiomalate was continued until both patients were in remission without any side effects.

show abstract

Section: Immunsuppressiver Therapieansatzunclassified

Gold

et al. 2007

View full text Add to dashboard Cite

show abstract

“…Baseline disease severity, which was assessed by different severity assessment tools, ranged from mild to severe; four trials did not report it [14,21,22,27] (Table 1).…”

Section: Trials Included In the Reviewmentioning

confidence: 99%

“…The follow-up period ranged from 1 to 60 months. The characteristics and main efficacy results of the 20 trials are displayed in Table 1 [8][9][10][11][12][13][14][15][16][17][18][19][20][21][22][23][24][25][26][27]. The majority of studies included patients with newly diagnosed disease [8, 10-12, 14, 16, 18, 21] or a combination of newly diagnosed disease and recurrent disease [9,13,19,20,22,25,27].…”

Section: Trials Included In the Reviewmentioning

confidence: 99%

Treatment of Pemphigus Vulgaris and Pemphigus Foliaceus: A Systematic Review and Meta-Analysis

et al. 2014

View full text Add to dashboard Cite

show abstract

“…Unless there are only localized oral lesions, in which case treatment with topical corticosteriods suffices for a time, systemic corticosteriods (e.g prednisolone) are essential, sometimes administered intravenously. Once the condition is under control , the dosage of prednisolone can be reduced (7,21,22). Adjuncts or alternatives include azathioprine, cyclosporin , cyclophosphamide, dapsone, levamisole, prostaglandin E2, chlorambucil and immunoglobulins (22)(23)(24).…”

Section: Introductionmentioning

confidence: 99%

Pemphigus vulgaris and complications of systemic corticosteroid therapy: a case report

Sakallıoğlu

Açıkgöz

Keleş

et al. 2003

Journal of Oral Science

View full text Add to dashboard Cite

Abstract:Pemphigus refers to a group of diseases characterized by painful lesions caused by intraepidermal acantholytic structures in the skin and mucous membrane. The exact nature of the disease remains unknown. Pemphigus is a rare chronic mucocutaneous disease characterized by intra-epithelial bulla formation, due to autoantibodies directed against proteins of the desmosome-tonofilament complex between keratinocytes. The bullous lesions are painful, slow to heal and with a tendency to become invasive. Any part of the oral cavity may be affected, with the soft palate, buccal mucosa and lips being the most common sites. The high doses and prolonged administration of corticosteroids often required to control the disease result in several side effects, many of which are serious or life-threatening. In the present case, steroid treatment was begun at 180 mg/day and subsequently increased to 250 mg/day and 350mg/day Oral lesions were treated locally with 0.2 % chlorhexidine gluconate in addition to systemic corticosteroids containing an immunosuppressive. Oral lesions were observed to recur without healing completely. Respiratory problems occured, necessitating direct lung radiographs and computerised tomography. Pulmonary embolism was diagnosed and the patient was transferred to the vascular surgery department. Unfortunately the patient died due to pulmonary embolism on the seventh day. Pemphigus vulgaris (PV) is a chronic autoimmune mucocutaneous disease that often primarily involves the oral cavity. Therefore, early diagnosis of oral symptoms is crucial for the successful treatment of PV. Although there is no consensus regarding the initial steroid dosage needed to induce remission, it is suggested that high doses of corticosteriods may cause fatal complications. (J. Oral Sci. 45, 165-169, 2003)

show abstract

Treatment of Oral Pemphigus Vulgaris

Abstract: Oral pemphigus most likely represents an initial stage of a disease that can become generalized. Administration of moderate doses of steroids alone is effective in controlling the disease.

Cited by 70 publications

References 24 publications

Gold

Gold

Treatment of Pemphigus Vulgaris and Pemphigus Foliaceus: A Systematic Review and Meta-Analysis

Pemphigus vulgaris and complications of systemic corticosteroid therapy: a case report

Contact Info

Product

Resources

About