Treatment of oral ranula in HIV-positive patient

Kusano, Yusuke; Ikeda, Ryoukichi; Saito, Yasuhito; Yamazaki, Masato; Tateda, Yutaka; Kitaya, Shiori; Shoji, Fumi; Suzuki, Takahiro; Noguchi, Naoya; Seki, Masafumi; Ohta, Nobuo

doi:10.1016/j.anl.2020.02.009

Cited by 3 publications

(1 citation statement)

References 11 publications

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“…Among the 32 included studies, there were a total of 489 patients with benign cystic lesions. Twenty patients were lost 33 2016 High Hasan 35 2018 High Kim 36 2012 Moderate Miwa 38 2007 High Woo 41 2003 High Wong 45 2017 Moderate Dool 48 2007 Moderate Kusano 50 2020 Moderate Monama 16 2010 High Watanabe 54 2002 High Taguchi 55 2005 Moderate Echavez 18 1994 High Total to follow-up and excluded from analysis, leaving 474 benign cystic lesions in 469 patients, including 5 patients with bilateral lesions. The mean duration of follow-up for all patients was 14.8 months (median, 14 months; range, 4-48 months).…”

Section: Demographicsmentioning

confidence: 99%

Sclerotherapy for Benign Cystic Lesions of the Head and Neck: Systematic Review of 474 Cases

Talmor

Nguyen

Mir

et al. 2021

Otolaryngol.--head neck surg.

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Objective The role of sclerotherapy for vascular lesions of the head and neck is well established. However, the efficacy of sclerotherapy for benign cystic lesions of the head and neck is less clear. The objective of this review is to determine the efficacy and safety of sclerotherapy for benign cystic lesions of the head and neck. Data Sources PubMed/MEDLINE, Cochrane Library, and Embase. Review Methods The PRISMA guidelines (Preferred Reporting Systems for Systematic Reviews and Meta-analyses) were followed for this systematic review. Studies of patients with benign head and neck cystic masses treated primarily with sclerotherapy were included. Thirty-two studies met criteria for inclusion. Results A total of 474 cases of sclerotherapy were reviewed. Agents comprised OK-432, ethanol, doxycycline, tetracycline, and bleomycin. Lesions in the analysis were ranula, thyroglossal duct cyst, branchial cleft cyst, benign lymphoepithelial cyst, parotid cyst, thoracic duct cyst, and unspecified lateral neck cyst. A total of 287 patients (60.5%) had a complete response; 132 (27.9%) had a partial response; and 55 (11.6%) had no response. OK-432 was the most widely utilized agent, with a higher rate of complete response than that of ethanol (62.0% vs 39.4%, P = .015). Fifty-three cases (11.2%) required further surgical management. One case of laryngeal edema was reported and managed nonoperatively. Conclusion Sclerotherapy appears to be a safe and efficacious option for benign cystic lesions if malignancy is reliably excluded. Efficacy rates are comparable to those of sclerotherapy for vascular malformations. The rate of serious complications is low, with 1 incident of airway edema reported in the literature.

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Section: Demographicsmentioning

confidence: 99%

Sclerotherapy for Benign Cystic Lesions of the Head and Neck: Systematic Review of 474 Cases

Talmor

Nguyen

Mir

et al. 2021

Otolaryngol.--head neck surg.

View full text Add to dashboard Cite

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OK-432 Treatment of Ranula Intruding into the Cervical Region

Ohta

Shirane

Fukase³

et al. 2022

Clinics and Practice

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Objectives: Plunging ranula intruding into the cervical region is rare and a standard therapy has not yet been consolidated. This paper investigates the outcomes and side effects of OK-432 treatment in patients with a ranula extending into the cervical region. Methods: The study design and setting consisted of a planned data collection at Tohoku Medical and Pharmaceutical University and Fukase Clinic. Eight patients with ranula extending into the cervical region received OK-432 treatment between January 2016 and February 2019. OK-432 treatment was performed for patients with ranula extending into the cervical region. Results: In all patients, a total shrinkage and marked reduction in lesions were observed without local scars or deformations after OK-432 treatment. Complications were local swelling and mild fever (37.5–38.5 °C), which lasted a few days in half of the patients. Conclusions: OK-432 treatment is straightforward, secure, and efficacious and can be substituted for surgery in the treatment of ranula extending into the cervical region.

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OK-432 treatment of pediatric patients with recurrent thyroglossal duct cyst after surgery

Ohta

Fukase²,

Nakazumi

et al. 2021

Otolaryngol Pol

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Introduction: Recurrent thyroglossal duct cyst after surgery is not a rare condition and first-line treatment has not been established yet. Aim: Evaluation of outcomes and complications of OK-432 treatment in patients with recurrent thyroglossal duct cyst after surgery. Material and methods: This study is designed as a case series with planned data collection at Tohoku Medical and Pharmaceutical University and Fukase Clinic. Five patients with recurrent thyroglossal duct cyst after surgery received this therapy between January 2014 and February 2020 on an outpatient basis, without hospitalization. OK-432 solution was injected into the lesion using an 18- or 27-gauge needle, depending on the location and size of the lesion, as well as on possible complications. Results: Lesions showed marked reduction or total shrinkage in all patients, with no local scarring or deformity at the injection site. Side effects manifested as local pain at the site of injection and fever (37.5–38.5°C) observed in three patients, but the symptoms resolved within a few days. Conclusions: Since OK-432 therapy is simple, easy, safe and effective, it can be used as an alternative to surgery in the treatment of recurrent thyroglossal duct cyst after surgery.

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Treatment of oral ranula in HIV-positive patient

Cited by 3 publications

References 11 publications

Sclerotherapy for Benign Cystic Lesions of the Head and Neck: Systematic Review of 474 Cases

Sclerotherapy for Benign Cystic Lesions of the Head and Neck: Systematic Review of 474 Cases

OK-432 Treatment of Ranula Intruding into the Cervical Region

OK-432 treatment of pediatric patients with recurrent thyroglossal duct cyst after surgery

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