Treatment of Oral Verrucous Carcinoma With Carbon Dioxide Laser

Azevedo, Luciane Hiramatsu; Galletta, V.; Eduardo, Carlos; Sousa, Suzana Cantanhede Orsini Machado de; Migliari, Dante Antônio

doi:10.1016/j.joms.2006.10.024

Cited by 13 publications

(12 citation statements)

References 29 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…6,7 Some studies have supported the use of the CO 2 laser for the surgical treatment of oral malignancies in the early stages (eg, T1N0 and T2N0 carcinomas) [8][9][10] or even more advanced stages of verrucous carcinoma. 11 Major advantages of the CO 2 laser mentioned in the literature include instant disinfection, nearly bloodless surgery, favorable wound healing, minimal scarring, and decreased postoperative pain. 3,4,[12][13][14] The CO 2 laser can be used in different modes, ranging from continuous wave to pulsed modes in the range of microseconds emitted with a defined frequency.…”

mentioning

confidence: 99%

Does a Pulsed Mode Offer Advantages Over a Continuous Wave Mode for Excisional Biopsies Performed Using a Carbon Dioxide Laser?

Suter

Altermatt²,

Dietrich

et al. 2012

Journal of Oral and Maxillofacial Surgery

View full text Add to dashboard Cite

mentioning

confidence: 99%

Does a Pulsed Mode Offer Advantages Over a Continuous Wave Mode for Excisional Biopsies Performed Using a Carbon Dioxide Laser?

Suter

Altermatt²,

Dietrich

et al. 2012

Journal of Oral and Maxillofacial Surgery

View full text Add to dashboard Cite

“…Utilizing a laser for excision biopsy of oral malignancy in an early stage has been reported. 25,[29][30][31] The nature of the lesion and water content appear to have an impact on the thermal effect during excision, as the most prominent thermal effect in our study was observed in a focal fibrous hyperplasia lesion. In the sample with the lowest value, the thermal effect in both epithelium and connective tissue was so minimal that it was considered by the pathologist to be proximal to 0 (≃).…”

Section: Discussionmentioning

confidence: 64%

Could the super-pulsed CO2 laser be used for oral excisional biopsies?

Tenore¹,

Palaia²,

Mohsen³

et al. 2019

Adv Clin Exp Med

View full text Add to dashboard Cite

Background. The main purpose of a biopsy is microscopic examination and diagnosis. Keeping the margins of specimens safe and readable is always fundamental to detecting marginal infiltrations or malignant transformation. Numerous options and tools have been introduced for biopsy procedures. Lasers are one of these options that provide many enhancements to clinical and surgical biopsy procedures in comparison to scalpels.Objectives. The aim of the present study is to quantify the thermal artefacts in histological specimens obtained using a CO 2 laser from different oral mucosal lesions and to evaluate if the resulting thermal effect hinders the histological examination. This aim is accomplished through quantitatively and qualitatively assessing the thermal effect in both the epithelium and connective tissue. Material and methods.A super-pulsed CO 2 laser (10,600 nm) was used to obtain 10 excision biopsy samples. The parameters were a power of 4.2 W in focused mode and a frequency of 80 Hz in super-pulse mode. The histological analysis was performed with an optical microscope. Computerized imaging software was utilized to quantitatively evaluate the thermal effect in both the epithelium and connective tissue expressed in microns. Results.The thermal effect of the CO 2 laser was limited to the surgical resection margins in all the specimens and did not hinder the histological analysis. Thermal artefacts were observed in 3 specimens. The range of thermal effects in the epithelial tissue was between 184 μm and 2,292 μm, while in the connective tissue it was between 133 μm and 2,958 μm. Conclusions.The resulting thermal effects of using a CO 2 laser did not hamper the histological evaluation. Utilizing a laser in biopsy procedures should be tailored. Not only should laser parameters and safety margins be taken into consideration but also the working time, clinical accessibility, and the nature and water content of the tissue.

show abstract

“…Laser microsurgery using a surgical microscope helps the surgeon distinguish between healthy and tumor tissue and preserve even more normal tissue by taking narrower margins. [33][34][35] The CO 2 laser has proved to be an effective means of treating verrucous carcinoma by total excision in cutting mode. 26 Verrucous carcinoma is a slow-growing, nonmetastasizing form of squamous cell carcinoma that is most frequently found in (but not limited to) the mouth.…”

Section: Malignant Lesions and Aggressive Benign Lesionsmentioning

confidence: 99%