Treatment of Orofacial Granulomatosis—9-Month Follow-up: A Case Report

Krasniqi, Mirlinda Sopi; Dalipi, Zana Sllamniku; Dragidella, Donika; Kondirolli, Labinota

doi:10.1177/11795476231160046

Cited by 1 publication

(2 citation statements)

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“…The treatment of OFG typically involves local and/or systemic corticosteroids [ 5 , 16 , 25 ]. All our patients received corticosteroid treatment, resulting in a significant improvement in oral manifestations 1 month after treatment initiation.…”

Section: Discussionmentioning

confidence: 99%

“…Te etiology of this disease has yet to be elucidated; however, it is reported to be associated with allergies and related diseases such as hay fever, bronchial asthma, and atopic dermatitis [1][2][3]. Furthermore, OFG tends to develop in individuals aged 20-40 years and limited literature has described its occurrence and management in pediatric patients [4,5]. Herein, we present a series of four pediatric patients who developed OFG in the lips and gingiva in one case and gingiva alone in three cases.…”

Section: Introductionmentioning

confidence: 99%

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Orofacial Granulomatosis among Pediatric Patients Well Controlled by Corticosteroid Treatment: A Rare Case Series

Kimura,

Sakata,

Takezaki

et al. 2024

Case Reports in Pediatrics

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Orofacial granulomatosis (OFG) is a rare disease entity characterized by nonnecrotizing granulomatous inflammation in the oral and maxillofacial regions, typically characterized by recurrent or persistent edema, primarily in the lips and occasionally in the gingiva. OFG is often associated with Crohn’s disease and sarcoidosis, and an accurate diagnosis requires systemic examination of patients. Pediatric patients possess unique oral conditions where dental plaque rapidly forms, especially during tooth replacement due to tooth crowding. Moreover, controlling oral hygiene can be challenging, rendering it difficult to distinguish plaque-induced gingivitis from nonplaque-induced gingivitis. We elucidate the reports of pediatric patients who developed OFG in the lips and/or gingiva alone, which was well controlled through corticosteroid treatment. The patients demonstrated recurrent lips and/or gingival swelling with redness, which failed to improve despite oral health care and treatment with antibiotics and/or corticosteroid ointment. Incision biopsy was performed, which demonstrated granulomatous inflammation. Further systemic examination ruled out Crohn’s disease and sarcoidosis and confirmed OFG diagnosis. Corticosteroid treatment orally or through gargling was administered to the patients, which provided improvement of symptoms after 1 month. As OFG may be associated with intractable diseases, monitoring the patient regularly is crucial. Pediatric patients with OFG require a collaborative approach with pediatricians and pediatric dentists to manage their oral and overall health.

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Section: Discussionmentioning

confidence: 99%