Treatment of osteoarthritis of the knee with a topical diclofenac solution: a randomised controlled, 6-week trial [ISRCTN53366886]

Baer, P.; Thomas, Lisa M.; Shainhouse, Zev

doi:10.1186/1471-2474-6-44

Cited by 99 publications

(86 citation statements)

References 24 publications

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“…The topical diclofenac solution was found to be significantly more effective than the other applications for the WOMAC pain, stiffness and physical function indices, and pain during activity as well as global patient assessment 13) . In a similar study by Baer et al 14) , patients with knee osteoarthritis were treated with topical diclofenac solution. Statistically significant improvements in WOMAC pain, stiffness and physical function, and patient global assessment scores were seen compared to a group treated with placebo.…”

Section: Discussionmentioning

confidence: 99%

Comparison of the Effectiveness of Pulsed and Continuous Diclofenac Phonophoresis in Treatment of Knee Osteoarthritis

et al. 2009

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Section: Discussionmentioning

confidence: 99%

Comparison of the Effectiveness of Pulsed and Continuous Diclofenac Phonophoresis in Treatment of Knee Osteoarthritis

et al. 2009

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“…Topical diclofenac and ibuprofen have been shown to be effective in acute soft tissue injuries, such as ankle sprains as well as arthritic knee pain [68,72,73]. Furthermore, topical diclofenac has been shown to be effective in reducing myofascial pain, however, with no effect on the myofascial trigger point pain threshold [74].…”

Section: Topical Analgesicsmentioning

confidence: 99%

Acute Pain Management in the Emergency Department

Samcam¹,

Papa²

2016

Pain Management

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The most common presenting complaint to the emergency department (emergency room) is pain. Unfortunately, pain is still undertreated in this setting. Literature has shown that treatment of pain not only improves patient satisfaction but also improves mood, decreases length of hospital stay, and decreases mortality. Various pharmacological options are available for treating acute pain, ranging from oral, intravenous, and intramuscular medications; topical agents; and peripheral nerve blocks. Objectively assessing and documenting a patient's pain is the key to determining treatment. The approach to a patient with acute pain requires an experienced clinician who is aware of the pharmacology of analgesics and anesthetics, contraindications, precautions, side effects, administration methods, and monitoring requirements.This chapter briefly covers the pathophysiology of acute pain and the different treatment modalities available to the emergency physician.

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“…In these studies, minor skin dryness was a common complaint in 36-39% of patients. In 5-6% of patients skin dryness lead to discontinuation of treatment [42,46]. More serious gastrointestinal complaints were limited and cardiovascular side effects were not evaluated.…”

Section: Randomised Clinical Trials Focused On Oa Of the Kneementioning

confidence: 99%

“…In RCTs involving patients with OA of the knee, 1.5% topical diclofenac induced a significant reduction in pain relief, morning stiffness and improvement in functional mobility and patient global assessment in patients in durations of 4 week [43], 6 week [42] and 12 week trials [46] compared to placebo. In these studies, minor skin dryness was a common complaint in 36-39% of patients.…”

Section: Randomised Clinical Trials Focused On Oa Of the Kneementioning

confidence: 99%

“…Several studies have shown the therapeutic benefits of topical diclofenac and its role in pain management where sufficient concentrations of diclofenac is distributed to the target tissue and in so doing produces a therapeutic effect. There are currently a range of published studies, meta-analyses and systematic reviews, and working party recommendations that have explored the use of topical diclofenac as part of pain management for patients with OA of the knee [41][42][43][44][45][46][47], sports injury [19], soft tissue injury [36,[48][49][50], actinic ketatoses [51] and acute migraine attacks [52]. Key studies are identified in Table 1.for OA of the knee and Table 2 for sports injury studies and meta-analyses.…”

Section: Clinical Efficacymentioning

confidence: 99%

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Topical diclofenac: clinical effectiveness and current uses in osteoarthritis of the knee and soft tissue injuries

Banning

2008

Expert Opinion on Pharmacotherapy

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Topical diclofenac: Clinical effectiveness and current uses in osteoarthritis of the knee and soft tissue injuries.Maggi Banning, EdD, M.Sc, PGDE, B.Sc. Senior lecturer, Brunel University.Background: Diclofenac is a commonly used non steroidal anti-inflammatory drug (NSAID) for symptom control in osteoarthritis (OA) of the knee and soft tissue injuries. Although treatment with oral diclofenac is associated with serious adverse effects involving both the gastrointestinal and renal systems, these adverse effects are thought to be limited with topical diclofenac formulations without loss of efficacy.Objective: the aim of this review is to explore the available evidence in relation to the pharmacokinetics, efficacy and reported adverse effects of the topical diclofenac formulations available. Results/conclusions: In the majority of studies examined, topical diclofenac formulations with sodium lotion, lecithin or epolamine gel, patch or plaster were either superior or equivalent to oral diclofenac formulations or placebo.Topical diclofenac significantly reduced pain and morning stiffness and improved physical function and patient global assessment without major adverse effects reported in patients with OA of the knee and provided significant pain relief in patients with sports and soft tissue injuries involving the ankle, knee or shoulder. In the majority of studies reported the predominant adverse effect involved pruritus or rash at the site of application or nausea. The principle outcome of these studies is that topical diclofenac is a safe and practical alternative as a method of treatment in OA of the knee or as an alternative treatment for sports and soft tissue injury.

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Treatment of osteoarthritis of the knee with a topical diclofenac solution: a randomised controlled, 6-week trial [ISRCTN53366886]

Cited by 99 publications

References 24 publications

Comparison of the Effectiveness of Pulsed and Continuous Diclofenac Phonophoresis in Treatment of Knee Osteoarthritis

Comparison of the Effectiveness of Pulsed and Continuous Diclofenac Phonophoresis in Treatment of Knee Osteoarthritis

Acute Pain Management in the Emergency Department

Topical diclofenac: clinical effectiveness and current uses in osteoarthritis of the knee and soft tissue injuries

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