“…None of the case reports excluded described an adverse event, but rather correspond to early clinical experience including technical tools. Finally, 12 reported clinical series were included, reporting outcomes from 375 patients corresponding to the following references as summarized in Table 1: A, 20 B, 21 C, 22 D, 23 E, 24 F, 25 G, 26 H, 27 I, 28 J, 29 K, 30 and L. 31 32,33 Once the membrane was placed over the microfractured defect by gluing, the stable position of the membrane was checked by flexing and extending the joint 10 times. • • In one study center, MFx was not always used but rather replaced or complemented by stem cell transplantation (study F, Gobbi et al 25 ), or not used at all and only bone marrow concentrate was used (study E, Skowronski et al 24 ).…”