Treatment of osteoporosis: Current status and recent advances

Theodorou, Daphne J.; Theodorou, Stavroula J.; Sartoris, David J.

doi:10.1007/s12019-002-0048-2

Cited by 9 publications

(4 citation statements)

References 163 publications

(153 reference statements)

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“…Treatment options for osteoporosis have substantially improved in recent years [1,2,[4][5][6]: appropriate antiresorptive or anabolic medications are available to prevent future fractures.…”

Section: Bisphosphonates Are the Most Common Therapy For Osteoporosismentioning

confidence: 99%

Differences in persistence, safety and efficacy of generic and original branded once weekly bisphosphonates in patients with postmenopausal osteoporosis: 1-year results of a retrospective patient chart review analysis

Ringe

Möller

2009

Rheumatol Int

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Section: Bisphosphonates Are the Most Common Therapy For Osteoporosismentioning

confidence: 99%

Differences in persistence, safety and efficacy of generic and original branded once weekly bisphosphonates in patients with postmenopausal osteoporosis: 1-year results of a retrospective patient chart review analysis

Ringe

Möller

2009

Rheumatol Int

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“…Durch die eff ektive Schmerzlinderung wird die Physiotherapie erleichtert, und die Patienten k ö nnen so ihre Mobilit ä t erhalten bzw. wiedererlangen [20] . Dar ü ber hinaus konnte eine signifi kante Reduktion der Beeintr ä chtigung von Alltagsaktivit ä ten (z.…”

Section: Zufriedenheit Mit Der Schmerztherapieunclassified

Oral osmotisches Hydromorphon für die symptomatische Behandlung chronischer Osteoporose bedingter Schmerzen unter alltäglichen Routinebedingungen

Ringe¹,

Hesselbarth²,

Vehreschild³

et al. 2010

Akt Rheumatol

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“…In recent treatment advances substances such as bisphosphonates, calcitonin, SERMs (raloxifene) and strontium ranelate are recommended more than estrogen. In addition, next to calcium and vitamin D application, bone stimulating agents such as parathyroid hormone or thiazide diuretics are applied for osteoporosis treatment (National Osteoporosis Foundation, 2008;Theodorou and Theodorou, 2002). The present study examined the effects of black cohosh extract BNO 1055 on metaphyseal fracture healing in ovariectomy-induced osteopenia in rats and compared its effect with that of 17-β-estradiol administered at a physiological dosage.…”

Section: Introductionmentioning

confidence: 99%

Absence of positive effect of black cohosh (Cimicifuga racemosa) on fracture healing in osteopenic rodent model

Kolios

Daub

Sehmisch

et al. 2010

Phytotherapy Research

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The healing of predominantly metaphyseal fractures in postmenopausal osteoporosis is delayed and comparatively poor. Due to the potential side effects of HRT, natural alternatives are appealing. The aim of this study was to determine whether Cimicifuga racemosa extract BNO 1055 improves metaphyseal fracture healing in severe osteopenic bone in rats. Thirty-three 12-week-old female rats developed severe osteopenia during 10 weeks after ovariectomy. After metaphyseal tibial-osteotomy and standardized T-plate-osteosynthesis, the healing periods in ovariectomized rats (C), 17-α-estradiol (E) and Cimicifuga racemosa (CR) supplemented diets were assessed for 35 days. Changes in callus morphology were evaluated qualitatively by biomechanical testing and quantitatively in microradiographies and fluorochrome-labeled histological sections. The CR-supplementation slightly improved callus quality and trabecular bone formation. It significantly enhanced the endosteal callus density compared to C group (Cl.Dn.e C: 59.08 ± 21.89, E: 45.95 ± 18.39, CR: 60.85 ± 18.66*), though most of the other morphological parameters examined showed no improvement. The time course of fracture healing did not change due to CR. Estrogen-supplementation enhanced the biomechanical properties of the fracture site. Trabecular bone was improved indicating the physiological endosteal healing process. The CR-supplementation did not exhibit positive effects in severe (senile) osteopenic fracture healing as seen in early (postmenopausal) osteoporosis in rats. Callus formation was slightly improved under CR. Estrogen improved fracture healing in severe osteopenic bone, while the extent of callus formation played a minor role.

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Treatment of osteoporosis: Current status and recent advances

Abstract: With the advent of new treatment choices, osteoporosis should no longer be considered an inevitable part of aging but rather a disease that can be treated. This article provides an overview of recent advances in treatment of osteoporosis.

Cited by 9 publications

References 163 publications

Differences in persistence, safety and efficacy of generic and original branded once weekly bisphosphonates in patients with postmenopausal osteoporosis: 1-year results of a retrospective patient chart review analysis

Differences in persistence, safety and efficacy of generic and original branded once weekly bisphosphonates in patients with postmenopausal osteoporosis: 1-year results of a retrospective patient chart review analysis

Oral osmotisches Hydromorphon für die symptomatische Behandlung chronischer Osteoporose bedingter Schmerzen unter alltäglichen Routinebedingungen

Absence of positive effect of black cohosh (Cimicifuga racemosa) on fracture healing in osteopenic rodent model

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