Treatment of pagetoid reticulosis with intensity modulated radiation therapy

Mount, Charles E.; Ferraro, D.J.; Gru, Alejandro A.; Bradbury, Matthew; Cornelius, Lynn A.

doi:10.5070/d32010024251

Cited by 4 publications

(6 citation statements)

References 9 publications

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“…The hallmark feature of WKD is the presence of atypical cytotoxic T‐lymphocytes confined to the epidermis and was confirmed in our analysis as 97.7% of the cases displayed epidermotropism 16 . Other histopathological findings include epidermal infiltration of atypical T‐lymphocytes that may exhibit pleomorphism, irregular or hyperchromatic nuclei, perinuclear “haloes,” “pagetoid” distribution, acanthosis, hyperkeratosis, and parakeratosis 5,17,18 …”

Section: Discussionsupporting

confidence: 75%

“…Age at diagnosis ranged from 2 years to 89 years, suggesting a wide age range at the time of presentation. 5,11 The most common manifestation of WKD appears to be a single, slow-growing, asymptomatic, erythematous plaque, which was confirmed in our analysis as 92.3% of cases presented as a slow-growing lesion, and 85% were plaques.…”

Section: Patient Characteristics and Clinical Presentationsupporting

confidence: 77%

“…Though previously thought to be most associated with males in the sixth decade and beyond, 10 our analysis found the average age of patient presentation to be 47.8 years with only a slight predilection for males with 54.6% of cases. Age at diagnosis ranged from 2 years to 89 years, suggesting a wide age range at the time of presentation 5,11 …”

Section: Discussionmentioning

confidence: 99%

“…The atypical T‐lymphocytes can present as either CD4+/CD8+, CD4+/CD8−, CD4−/CD8+, or CD4−/CD8− 2 . This variability is also present for other immunohistochemical markers, compromising their utility as a diagnostic tool for WKD 5 …”

Section: Introductionmentioning

confidence: 99%

“…2 This variability is also present for other immunohistochemical markers, compromising their utility as a diagnostic tool for WKD. 5 Numerous therapeutic options for WKD are available and include surgical excision, radiotherapy, photochemotherapy, localized chemotherapy, and psoralen plus ultraviolet A (PUVA). 6 As a result of the varying efficacy of each modality, patients are often treated with a combination of techniques.…”

Section: Introductionmentioning

confidence: 99%

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Woringer‐Koloppdisease (localized pagetoid reticulosis): a systematic review

et al. 2022

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Objective Woringer-Kolopp disease (WKD), also known as localized pagetoid reticulosis, is a rare variant of mycosis fungoides as described by the World Health Organization-European Organization for Research and Treatment of Cancer (WHO-EORTC) classification system for cutaneous lymphomas. Our objective was to conduct a comprehensive review that describes and evaluates patient demographics, clinical presentation, immunohistochemical findings, management, and outcomes of WKD. Methods The databases PubMed, Embase, and Cochrane Library were searched for relevant literature. Patient demographics, imaging, treatments, and other clinical characteristics were obtained. The literature search was conducted on December 7, 2020.Studies were included if they contained primary data related to WKD. Non-pertinent studies, non-English studies, non-human studies, review articles, or studies with insufficient case information were excluded. The quality of the included studies and the risk of bias were evaluated using the Grades of Recommendation, Assessment, Development, and Evaluation Group (GRADE) criteria ( 2016), Oxford Centre for Evidence-Based Medicine: Levels of Evidence (OCEBM) (March 2009), and the Methodological Index for Non-Randomized Studies (MINORS) criteria (2003).Results A total of 84 studies with 143 patients met the inclusion criteria for this study. The most common chief complaint was an asymptomatic, slow-growing, and erythematous plaque. The average time from initial skin eruption to presentation was 97.6 months.Histologically, 128 cases of WKD displayed epidermotropism (97.7%). Various therapies, including radiotherapy, surgery, and local chemotherapy, were used. In total, 92 (78.6%) cases had complete remission and 11 (9.4%) cases recurred. Conclusions WKD is a rare cutaneous T-cell lymphoma that often presents as a single plaque on the extremities with an indolent course and a favorable prognosis. However, it is often misdiagnosed, leading to delays in treatment. The diagnosis of WKD involves clinical appraisal, a biopsy of suspicious lesions, and immunohistochemistry. Monotherapy appears to be preferred compared to combination therapy for WKD with radiotherapy demonstrating among the highest cure rates and lowest recurrence. Future retrospective and prospective studies are needed to accurately determine the epidemiology, prognosis, and effective treatments for WKD. Limitations include a possibility of missed studies, heterogeneity in reporting methods, publication, and selection bias.What is already known about this topic?• Woringer-Kolopp disease (WKD) is a rare variant of mycosis fungoides as described by the World Health Organization-European Organization for Research and Treatment of Cancer (WHO-EORTC) classification system for cutaneous lymphomas.• Qualitative systematic analysis can generate new insights compared to individual findings.What does this study add?• Demonstrates the need for accurate diagnosis of Cutaneous T-Cell Lymphomas.

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Section: Discussionsupporting

confidence: 75%

Section: Patient Characteristics and Clinical Presentationsupporting

confidence: 77%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Woringer‐Koloppdisease (localized pagetoid reticulosis): a systematic review

et al. 2022

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Annular Scaly Plaque on the Left Foot: Answer

Hijazi¹,

Sprinkle

Sangüeza³

2018

The American Journal of Dermatopathology

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Pagetoid Reticulosis: Report of Two Cases and Review of the Literature

Larson

Wick²

2016

Dermatopathology

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Pagetoid reticulosis is a rare variant of mycosis fungoides that presents with a large, usually single, erythematous, slowly growing scaly plaque containing an intraepidermal proliferation of neoplastic T lymphocytes. Histopathologically, this disease has distinctive attributes. In this report, we present two cases of pagetoid reticulosis, compare its microscopic features to those of ‘classical' mycosis fungoides, and provide a brief review of the pertinent literature.

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Treatment of pagetoid reticulosis with intensity modulated radiation therapy

Cited by 4 publications

References 9 publications

Woringer‐Koloppdisease (localized pagetoid reticulosis): a systematic review

Woringer‐Koloppdisease (localized pagetoid reticulosis): a systematic review

Annular Scaly Plaque on the Left Foot: Answer

Pagetoid Reticulosis: Report of Two Cases and Review of the Literature

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