Treatment of Pain in Cancer: Towards Personalised Medicine

Everdingen, M.H.J. van den Beuken-van; Kuijk, Sander M. J. van; Janssen, Daisy J.A.; Joosten, Elbert A.J.

doi:10.3390/cancers10120502

Cited by 49 publications

(46 citation statements)

References 71 publications

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“…Neuropathic cancer pain is associated with poor outcomes [7,8]. A study in 2012 found that neuropathic cancer pain was associated with more oncological treatment, greater analgesic requirements (including strong opioids and adjuvant analgesics) and reduced performance status than those with nociceptive pain [8].…”

Section: Definitions and Epidemiologymentioning

confidence: 99%

Cancer-Related Neuropathic Pain

Edwards

Mulvey

Bennett

2019

Cancers

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Neuropathic pain in cancer is common and debilitating. It is important to differentiate neuropathic pain from other cancer-related pains as it is associated with worse pain outcomes and requires different treatment strategies. This review summarises recent updates to pain classification, aetiology, pain assessment and current recommendations for treatment in patients with cancer-related neuropathic pain.

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Section: Definitions and Epidemiologymentioning

confidence: 99%

Cancer-Related Neuropathic Pain

Edwards

Mulvey

Bennett

2019

Cancers

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“…Bone cancer pain (BCP) is often severe and intractable, and has a strong effect on the quality of life of cancer patients. But no breakthrough has been achieved yet with regard to the therapeutic strategies and mechanisms of BCP (Falk and Dickenson, 2014;van den Beuken-van Everdingen et al, 2018). Therefore, novel and more efficacious therapies are imperative to improve the quality life of patients.…”

Section: Introductionmentioning

confidence: 99%

Liquiritin Alleviates Pain Through Inhibiting CXCL1/CXCR2 Signaling Pathway in Bone Cancer Pain Rat

Xie

et al. 2020

Front. Pharmacol.

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Bone cancer pain (BCP) is an intractable clinical problem, and lacked effective drugs for treating it. Recent research showed that several chemokines in the spinal cord are involved in the pathogenesis of BCP. In this study, the antinociceptive effects of liquiritin, which is an active component extracted from Glycyrrhizae Radix, were tested and the underlying mechanisms targeting spinal dorsal horn (SDH) were investigated. The BCP group displayed a significant decrease in the mechanical withdrawal threshold on days 6, 12, and 18 when compared with sham groups. Intrathecal administration of different doses of liquiritin alleviated mechanical allodynia in BCP rats. The results of immunofluorescent staining and western blotting showed that liquiritin inhibited BCPinduced activation of astrocytes in the spinal cord. Moreover, intrathecal administration of liquiritin effectively inhibited the activation of CXCL1/CXCR2 signaling pathway and production of IL-1b and IL-17 in BCP rats. In astroglial-enriched cultures, Lipopolysaccharides (LPS) elicited the release of chemokine CXCL1, and the release was decreased in a dose-dependent manner by liquiritin. In primary neurons, liquiritin indirectly reduced the increase of CXCR2 by astroglial-enriched-conditioned medium but not directly on the CXCR2 target site. These results suggested that liquiritin effectively attenuated BCP in rats by inhibiting the activation of spinal astrocytic CXCL1 and neuronal CXCR2 pathway. These findings provided evidence regarding the the antinociceptive effect of liquiritin on BCP.

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“…11 In fact, 40% of cancer patients have reported to experience pain in varying degrees. 12,13 A number of studies conducted in European countries and in other parts of the world also revealed similar results, 14–16 however, inadequate pain management in cancer is indeed a current challenge in China. As far as we know, one of the problems is the regulation of opioid distribution and its accessibility for treatment purposes.…”

Section: Introductionmentioning

confidence: 67%

A multicentre survey of pain management in cancer patients and physicians attending radiotherapy clinics in Shandong Province, China

Tan

et al. 2019

J Int Med Res

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Objective To obtain a better understanding of the prevalence and management of pain in patients undergoing radiotherapy for cancer in Shandong Province, China. Methods This cross-sectional study used a questionnaire during face-to-face interviews to collect data from physicians and patients regarding the recognition, prevalence and treatment of pain during the waiting period before commencement of radiotherapy and during the radiotherapy period. Physicians and patients were recruited from 10 tertiary Class A hospitals across Shandong Province, China. Results A total of 184 patients and 87 physicians were recruited to the study. During the waiting period, pain was reported by the physicians according to their experience to affect 26.0% of patients, which almost agreed with the patients’ data (36.5%; 160 of 438). During the radiotherapy period, there was a significant difference in the reported prevalence of pain during the radiotherapy period between the physicians’ data (23.0%) based on their experience and the patients’ data (84.1%; 169 of 201 patients). The majority of physicians (98.9%; 86 of 87) agreed to the use opioids for pain management and 90.8% (79 of 87) were satisfied with the analgesic effect, but more than half of the patients who received pain treatment reported inadequate analgesia. Conclusion There was a high incidence of cancer pain, but insufficient assessment, inadequate treatment and inadequate education about pain in both the waiting and radiotherapy periods.

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Treatment of Pain in Cancer: Towards Personalised Medicine

Cited by 49 publications

References 71 publications

Cancer-Related Neuropathic Pain

Cancer-Related Neuropathic Pain

Liquiritin Alleviates Pain Through Inhibiting CXCL1/CXCR2 Signaling Pathway in Bone Cancer Pain Rat

A multicentre survey of pain management in cancer patients and physicians attending radiotherapy clinics in Shandong Province, China

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