Treatment of Papillon‐Lefèvre syndrome periodontitis

Pacheco, J. J.; Coelho, Carlos; Salazar, Filomena; Contreras, Adolfo; Slots, Jørgen; Velazco, Corsina

doi:10.1034/j.1600-051x.2002.290414.x

Cited by 50 publications

(53 citation statements)

References 28 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Of the 31 papers retrieved, 13 reported on the use of microbial analysis to guide patient treatment. [10][11][12][13][14][15][16][17][18][19][20][21][22] Another 11 reported a differential response to treatment depending on the detection or lack of detection of specific microorganisms. [23][24][25][26][27][28][29][30][31][32][33] The remaining papers were included primarily as background references.…”

Section: Resultsmentioning

confidence: 99%

See 1 more Smart Citation

Microbial Identification in the Management of Periodontal Diseases. A Systematic Review

Listgarten

Loomer

2003

Ann Periodontol

View full text Add to dashboard Cite

1. The published material suggests that microbiological monitoring may be useful in management of selected patients who do not respond to standard therapy. 2. Some practitioners consider microbial identification a valuable adjunct to managing patients with certain forms of periodontitis, although there is a lack of strong evidence to this effect. 3. Additional research is needed to address this issue.

show abstract

Section: Resultsmentioning

confidence: 99%

“…In the remaining 10 reports, 10,13,14,[16][17][18][19][20][21][22] 13 of the 17 patients presented had reportable data. Of these, all but one 22 had been treated with adjunctive antibiotics.…”

Section: Articles Reporting the Use Of Microbiological Identificationmentioning

confidence: 91%

Microbial Identification in the Management of Periodontal Diseases. A Systematic Review

Listgarten

Loomer

2003

Ann Periodontol

View full text Add to dashboard Cite

show abstract

“…Some case reports described favorable results after early extraction of all erupted teeth, followed by an edentulous period, to prevent subsequent infection of the non-erupted teeth [10,11,[35][36][37]. However, successful cases in which A. actinomycetemcomitans had either not been detected before treatment or had been eliminated by treatment have also been described that did not include large-scale extractions [7,9,32,[38][39][40]. Success of periodontal therapy in PLS may be related to infection with A. actinomycetemcomitans and its elimination, respectively.…”

Section: Discussionmentioning

confidence: 95%

Cytokine production by leukocytes of Papillon–Lefèvre syndrome patients in whole blood cultures

et al. 2011

View full text Add to dashboard Cite

Papillon-Lefèvre syndrome (PLS) is characterised by aggressively progressive periodontitis combined with palmo-plantar hyperkeratosis. It is caused by "loss of function" mutations in the cathepsin C gene. The hypothesis behind this study is that PLS patients' polymorphonuclear leukocytes (PMNs) produce more proinflammatory cytokines to compensate for their reduced capacity to neutralize leukotoxin and to eliminate Aggregatibacter actinomycetemcomitans. Production of more interleukin (IL)-8 would result in the attraction of more PMNs. The aim of this study was to evaluate the cytokine profile in PLS patients' blood cultures. Blood was sampled from eight PLS patients (one female) from six families (antiinfective therapy completed: six; edentulous: two) with confirmed cathepsin C mutations and deficient enzyme activity. Nine healthy males served as controls. Whole blood cultures were stimulated with highly pure lipopolysaccharide (LPS) from Escherichia coli R515 and IL-1β plus tumor necrosis factor (TNF)-α. Thereafter, release of IL-1β (stimulation: LPS and LPS plus adenosine triphosphate), IL-6, IL-8, interferon-inducible protein (IP)-10, and interferon (IFN)-γ (stimulation: LPS, IL-1β/TNFα) were detected by ELISA. Medians of cytokine release were, with the exception of IP-10, slightly higher for PLS than for controls' cultures. None of these differences reached statistical significance. Increased production of IL-1β, IL-6, IL-8, IP-10, or IFNγ as a significant means to compensate for diminished activity and stability of polymorphonuclear leukocyte-derived proteases could not be confirmed in this study. Cytokine profiles in blood cultures may not be used to identify PLS patients.

show abstract

“…Pueden ser afectados ambos tipos de denticiones. Estudios de asociación con este síndrome han mostrado que está causado por la mutación del gen de la catepsina, localizado en el cromosoma 11 (55,56). La catepsina C es una cistein-proteasa expresada de forma abundante en varios tejidos incluido el epitelio y algunas células del sistema inmune como los polimorfonucleares.…”

Section: Desórdenes Genéticosunclassified

El papel de la genética en la aparición y desarrollo de la periodontitis: I: evidencias científicas de la asociación entre periodontitis y genética

Rodrigo-Gómez¹,

Oteo-Calatayud²,

Alonso-Rosado

et al. 2007

Avances en Periodoncia

View full text Add to dashboard Cite

Treatment of Papillon‐Lefèvre syndrome periodontitis

Abstract: This study suggests that controlling the periodontopathic microbiota by appropriate antibiotic and conventional periodontal therapy can arrest Papillon-Lefèvre syndrome periodontitis.

Cited by 50 publications

References 28 publications

Microbial Identification in the Management of Periodontal Diseases. A Systematic Review

Microbial Identification in the Management of Periodontal Diseases. A Systematic Review

Cytokine production by leukocytes of Papillon–Lefèvre syndrome patients in whole blood cultures

El papel de la genética en la aparición y desarrollo de la periodontitis: I: evidencias científicas de la asociación entre periodontitis y genética

Contact Info

Product

Resources

About