Treatment of Pathological Gambling with Carbamazepine

Haller, Reinhard; Hinterhuber, Hartmann

doi:10.1055/s-2007-1014292

Cited by 82 publications

(22 citation statements)

References 0 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The inhibitors commonly in use are Clomipramine and Fluvoxamine. Many reports exist in the literature on the use of these agents with some success regarding several parameters of pathological gambling such as decreased gambling urge and gambling behaviour [102][103][104]. Second lines of treatment have involved mood stabilizers.…”

Section: Pharmacotherapy Of Pathological Gambling (Pg)mentioning

confidence: 99%

See 1 more Smart Citation

Amino Acids in Pathological Gambling and in its Alleviation: Pharmacological Approaches

Gupta¹

2010

TOADDJ

View full text Add to dashboard Cite

Labelling Pathological gambling (PG) with a tag of Socio-Psychological problem more than medical causes hampers its pharmacological treatment. Because of this, its neurobiology has been studied only a little, limited to abnormalities in the serotonergic, noradrenergic and dopaminergic systems. Besides this; studies on the role of precursors of these neurotransmitters are almost negligible. Higher concentrations of known precursors like tryptophan, tyrosine and phenyl alanine have been reported in the CSF of pathological gamblers. In addition to this, recently many other inhibitory and excitatory amino acids like GABA, taurine, aspartic and glutamic acids have been found to be in much higher concentration, providing a basis for the candidate amino acids in the therapy of PG. Many of these amino acids have beneficial actions in a number of CNS problems. On this basis, as most of these amino acids are non-toxic and natural, such amino acids can be used as supplements /compliments in PG therapy. One of these amino acids, taurine, a sulfur containing amino acid which is now part of various energy drinks, anti-ageing and anti-diabetes formulas, mood enhancers and many more alternative medicine applications, also could exert beneficial actions in alleviating PG. Therapy with amino acids also has its own limitations; hence development of pro-drug derivatives of these amino acids may constitute a new class of therapeutic agent for PG. This review is a blended form of synthesis and synopsis about various amino acids in the context of PG, considering their potential utility and providing a provocative stimulus for scientific thinkers.

show abstract

Section: Pharmacotherapy Of Pathological Gambling (Pg)mentioning

confidence: 99%

“…Though some data are available in the literature, it is unclear how much improvement specific to gambling has been achieved. Another agent Carbamazepine is also in use as a mood stabilizer with improvement in gambling behaviour [104]. The third sets of agents used are opioid antagonists.…”

Section: Pharmacotherapy Of Pathological Gambling (Pg)mentioning

confidence: 99%

Amino Acids in Pathological Gambling and in its Alleviation: Pharmacological Approaches

Gupta¹

2010

TOADDJ

View full text Add to dashboard Cite

show abstract

“…In addition, in an open-label trial, the serotonin antagonist nefazodone has been found to be effective in PG. 97 PG seems to respond to a wider range of monotherapies than OCD; notably, there are case reports 98,99 and a singleblind study 100 suggesting that mood stabilizers are effective in PG.We recently completed a double-blind, placebo-controlled study of sustained-release lithium in PG patients with comorbid bipolar disorder. Lithium significantly improved both impulsive gambling and affective instability compared with placebo in this population.…”

Section: Pathological Gamblingmentioning

confidence: 99%

The obsessive-compulsive spectrum disorders

Hollander

Benzaquen²

1997

International Review of Psychiatry

133

127

View full text Add to dashboard Cite

“…Case reports of pathological gambling (PG) have shown abstinence from gambling or reduced levels of gambling with self-help gamblers anonymous groups (Comer, 1978), as well as with the medications carbemazepine (Haller & Hinterhuber, 1994), chlomipramine (Hollander, Frenkel, DeCaria, Trungold, & Stein, 1992), and citalopram (Zimmerman, Breen, & Posternak, 2002). Small-sample randomassignment controlled studies have shown that amelioration can occur with cognitive-behavioral therapy (Ladouceur et al, 2001;Toneatto & Sobell, 1990), fluvoxamine (Hollander, 2000), and naltrexone (Kim, Grant, Adson, & Shin, 2001).…”

Section: Introduction Literature Reviewmentioning

confidence: 99%

“…Short-term outcomes, i.e., under a few months, in uncontrolled studies have ranged from 100% improvement in the anecdotal cases (Comer, 1978;Haller & Hinterhuber, 1994;Hollander et al, 1992;Toneatto & Sobell, 1990) to 87% in an open-label study (Hollander et al, 1998). Controlled studies have shown much lower short-term rates, i.e., 7-28% improvement with placebo versus 33%, 54%, and 75% improvement with fluvoxamine, cognitive therapy, and naltrexone (Hollander, 2000;Kim et al, 2001;Ladouceur et al, 2001).…”

Section: Introduction Literature Reviewmentioning

confidence: 99%

Remission from Pathological Gambling among Hispanics and Native Americans

Westermeyer

Cañive²,

Thuras

et al. 2006

Community Ment Health J

View full text Add to dashboard Cite

This community survey studied remission from pathological gambling (PG) among American Indian (AI) and Hispanic American (HA) veterans. Remission was defined as having a lifetime diagnosis of PG, but no gambling symptoms in the last year. Sample consisted of 1624 AI and Hispanic veterans. Instruments included demographic data, the computer-based algorithmic Quick Diagnostic Interview Schedule Symptom, and three symptom checklists, one each for substance related problems (MAST/AD), anxiety and depressive symptoms (BSI-57), and combat-related post-trauma symptoms (PCL/M). Remission was associated with absence of a current Axis 1 diagnosis, especially absence of a current post-traumatic stress disorder.

show abstract

Treatment of Pathological Gambling with Carbamazepine

Cited by 82 publications

References 0 publications

Amino Acids in Pathological Gambling and in its Alleviation: Pharmacological Approaches

Amino Acids in Pathological Gambling and in its Alleviation: Pharmacological Approaches

The obsessive-compulsive spectrum disorders

Remission from Pathological Gambling among Hispanics and Native Americans

Contact Info

Product

Resources

About