Treatment of patients with venous insufficiency with fresh plant horse chestnut seed extract: A review of 5 clinical studies

Abstract

Extracts from the seed of the horse chestnut (Aesculus hippocastanum L.) have traditionally been used to treat patients with chronic venous insufficiency and to alleviate its associated symptoms, including lower leg swelling. The efficacy of preparations that contain horse chestnut seed extract (HCSE) is believed to be due largely to an inhibitory effect on the catalytic breakdown of capillary wall proteoglycans. Aesculaforce is a fresh plant HCSE that is available as an oral tincture, as tablets (20 mg or 50 mg), and as topical gel. Four clinical trials in patients with chronic venous insufficiency and 1 study in patients with varicose veins demonstrated the effectiveness of these preparations through the objective measure of reduction in lower leg edema and the subjective alleviation of leg pain, heaviness, and itching. Safe, well tolerated, and acceptable to patients, the fresh plant HCSE preparation Aesculaforce offers a real alternative in the treatment of patients with mild to moderate venous insufficiency.

Rare adipose disorders (RADs) masquerading as obesity

“…9) Flavonoids: Daflon is a flavonoid that has been used to treat lymphedema [171][172][173] ; it may be expensive and is unlikely available by prescription. Other flavonoids such as those for venous disease [174] have not been formerly tested in lipedema participants. The International Society of Lymphology does not endorse the use of flavonoids as a substitute for LDT.…”

Horse Chestnut (Aesculus Hippocastanum) for Venous Insufficiency

“…It is also combined with butcher's broom (Ruscus aculeatus) and Gotu cola (Centella asiatica) for the treatment of cellulite, keloid scars, hematomas and easy bruising , dermatological conditions, telangectasias, anal fissures, perineal lesions, burns, and general wound regeneration [20][21][22][23].…”

EFFECTS OF LIGHT AND MOISTURE ON GROWTH AND MORPHOLOGICAL CHARACTERISTICS OF HORSECHESTNUT (Aesculus hippocastanum L.) SEEDLINGS IN THE WESTERN BLACKSEA REGION IN TURKEY

“…In this context, to give immediate response to differences in root length 50% humidity, and light intensity, but light buds length and remains unresponsive to differences in growth medium intensity up to 60% humidity. After this issue made especially moisture content of 40% root length of the horse chestnut trees in a similar research is increasing rapidly and it is emphasized that this case can easily be determined in light textured soils (Suter et al, 2006).…”