The purpose of this study was to determine return-to-play (RTP), performance and career survivorship for National Football League (NFL) athletes sustaining pectoralis major (PM) injuries with comparison among grades of injury and between nonoperative and operative management. Methods: Publicly available data from the 1998e2020 NFL seasons were reviewed to identify athletes with PM injuries. Athlete characteristics were collected 1 season before and 2 seasons after injury. Percent of total games played in a season, player efficiency rating (PER), and Pro Football Focus (PFF) grades were compared for the preinjury season and 2 postinjury seasons. Kaplan-Meier survivorship plots were computed for RTP and postinjury career length, whereas a log-rank test was used to compare survivorship differences. Results: In total, 258 PM injuries were reported at a mean age of 27.1 AE 3.3 years. A total of 126 surgical repairs occurred in 48.8% (n ¼ 126) of injuries, with athletes undergoing repair possessing a lower RTP rate and longer time to RTP compared to athletes treated conservatively (P < .001). Survival analysis revealed shorter career length for athletes sustaining PM tears compared to strains (P < .001), although no difference in career length was appreciated on the basis of injury management (P ¼ .980). Defensive linemen and wide receivers had lower PER during their second postinjury seasons (P ¼ .019 and .030, respectively), whereas defensive linemen had lower PFF grades during their second post-injury seasons (P ¼ .044). Conclusion: NFL athletes requiring PM repair may experience a lower likelihood of RTP, and longer RTP timing, likely because of higher-grade injuries. Defensive linemen and wide receivers experiencing PM injuries are at risk for diminished performance post-injury. Career length does not appear to be affected based on injury management. Level of Evidence: Level III, cohort study. P ectoralis major (PM) injuries are uncommon injuries that generally occur during weightlifting when an eccentric load is placed on the arm with the shoulder in extension, abduction, and external rotation. 1,2 A subset of PM injuries has been reported during sports competition, such as American football. 1,[3][4][5][6][7][8][9][10][11][12][13] Recent evidence supports repair over nonoperative management for complete PM tears, with operatively treated patients demonstrating superior functional outcomes, strength, and cosmesis when compared to those treated conservatively. 1,2,4,[14][15][16][17] However, there remains a role for nonoperative management and physical therapy for athletes with lower grade PM strains and partial tears; however, comparative studies are lacking. 1,15,16 The PM muscle is a fan-shaped muscle over the anterior thorax with 2 distinct heads: a sternocostal head and clavicular head. 1,18,19 The sternocostal head arises from the sternum and ribs and the clavicular head arises from the proximal half of the clavicle. 1,18,19 These heads converge into a tendon distal to the axilla, From Midwest Orthopaedics a...