Treatment of pediatric molluscum contagiosum with 10% potassium hydroxide solution

Can, Burçe; Topaloglu, Filiz; Kavala, Mukaddes; Türkoğlu, Zafer; Zindancı, İlkin; Sudogan, Sibel

doi:10.3109/09546634.2012.697988

Cited by 24 publications

(18 citation statements)

References 9 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Erythema (33.3%), pruritus (22.2%), desquamation (18.5%), contact allergic (5.5%), and irritant dermatitis (5.5%) were also noted, but their frequency was not statistically significant. Burning sensation or stinging during application was the most common side effect of KOH in previous studies, similar to this study, 7,9,14,20 while others have also noted erythema and crusting, 20 hyperpigmentation, 10,17 and hypopigmentation. 12, 13 Short reported both stinging (20%) and hyperpigmentation (20%) as the most common side effects.…”

Section: Side Effects Of Therapiessupporting

confidence: 89%

“…In other work where skin phototypes were not specified, only one of the three hypopigmentation conditions persisted. 17 Permanent hypopigmentation as a complication of KOH treatment is considered as the most important and undesired side effect in dark skinned Sudanese children evaluated in this study.…”

Section: Side Effects Of Therapiesmentioning

confidence: 88%

“…12, 13 Short reported both stinging (20%) and hyperpigmentation (20%) as the most common side effects. 21 A secondary infection with prolonged treatment, 7,17 hypertrophic scar, 17 ulceration, 12,14,19,22 erythema, 9,12,14,15,19 pruritus, 9,12,14 desquamation, 9,12,14,15,19 hypopigmentation, 13,14,17 and hyperpigmentation 9,13,17,19 are other side effects of KOH in the treatment of MC reported in the literature.…”

Section: Side Effects Of Therapiesmentioning

confidence: 99%

“…[4][5][6] Keratolytic solutions act by dissolving the keratin, causing local destruction of the skin. 7 Previous studies have shown the efficacy of KOH in the treatment of MC, in various concentrations and comparisons with other treatments since 1999 [7][8][9][10][11][12][13][14][15][16][17][18][19][20][21][22] as well as topical SAL preparations. 9,15,22,23 There are only two studies that have assessed efficacy of KOH in comparison with SAL in fair skinned children with MC.…”

Section: Introductionmentioning

confidence: 99%

See 3 more Smart Citations

Efficacy and Side Effects of Topical Applications of Two Different Solutions in the Treatment of Molluscum Contagiosum in a City in Africa: An Open, Randomized, Comparative Clinical Trial

Öztürk

2019

J Pediatr Infect Dis

View full text Add to dashboard Cite

Molluscum contagiosum (MC) is one of the most common viral infections in African children. However, there is no work investigating the treatment of MC in dark skinned children in Africa. In this study, we aimed to compare efficacy and side effects of topical application of 10% potassium hydroxide (KOH) and 16.7% salicylic acid (SAL) and lactic acid (LAC) combination in the treatment of MC in Sudan, Africa. This is a prospective, randomized, and comparative study. The inclusion criterion was the presence of at least 10 lesions. The exclusion criteria were the use of any topical MC treatment during the last 2 weeks, immunosuppression, periorbital and perioral involvement, the history of hypersensitivity to any kind of keratolytics, and the presence of concomitant bacterial skin infections. The main efficacy outcome was the complete remission or partial remission. Three visits were performed: baseline visit (diagnosis, randomization, and therapy initiation), visit 1 for follow-up (at 15–30 days after initiation of therapy and for study end), and visit 2 for postclearing assessment (at 60th day after the initiation of therapy). Chi-squared (χ2) test was used. All patients (n = 101) participating completed the 60 days of follow-up period. Post 60 days of treatment, the rates of complete resolution in 55 patients treated with 10% KOH solution and 47 patients treated with 16.7% SAL + LAC combination solution were 87.0 and 85.1% (p > 0.05), respectively. The rates of partial resolution in the group treated with KOH solution and in patients treated with SAL + LAC combination solution were 12.9% and 14.8% (p > 0.05), respectively. Major side effects in KOH group were burning sensation or stinging during application (48.1%, p = 0.0009) and hypopigmentation (38.8%, p = 0.007) while it was desquamation (23.4%, p > 0.05) in the SAL + LAC combination group. Results indicate both 10% KOH solution and SAL + LAC combination solution showed good efficacy in the treatment of MC in African children. Neither 10% KOH nor the SAL + LAC combination solution was found superior to other in the treatment, while the latter was noted to have fewer side effects. Permanent hypopigmentation is an important and undesired side effect of 10% KOH treatment.

show abstract

Section: Side Effects Of Therapiessupporting

confidence: 89%

Section: Side Effects Of Therapiesmentioning

confidence: 88%

Section: Side Effects Of Therapiesmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Efficacy and Side Effects of Topical Applications of Two Different Solutions in the Treatment of Molluscum Contagiosum in a City in Africa: An Open, Randomized, Comparative Clinical Trial

Öztürk

2019

J Pediatr Infect Dis

View full text Add to dashboard Cite

show abstract

“…Recently, some studies have demonstrated the effectiveness of potassium hydroxide (KOH), in various concentrations of 5%, 15% and 20% for MC treatment (2)(3)(4)(5). However, there is no study comparing KOH treatment with cryotherapy.…”

Section: Introductionmentioning

confidence: 99%

Comparison of 10% potassium hydroxide solution versus cryotherapy in the treatment of molluscum contagiosum: An open randomized clinical trial

Handjani

Behazin²,

Sadati

2013

Journal of Dermatological Treatment

View full text Add to dashboard Cite

show abstract

Interventions for cutaneous molluscum contagiosum

Wouden

Sande

Kruithof

et al. 2017

Cochrane Database of Systematic Reviews

View full text Add to dashboard Cite

No single intervention has been shown to be convincingly effective in the treatment of molluscum contagiosum. We found moderate-quality evidence that topical 5% imiquimod was no more effective than vehicle in terms of clinical cure, but led to more application site reactions, and high-quality evidence that there was no difference between the treatments in terms of short-term improvement. However, high-quality evidence showed a similar number of general side effects in both groups. As the evidence found did not favour any one treatment, the natural resolution of molluscum contagiosum remains a strong method for dealing with the condition.

show abstract

Treatment of pediatric molluscum contagiosum with 10% potassium hydroxide solution

Abstract: Even though 10% KOH solution is associated with some local side effects, it is a safe, effective, inexpensive and noninvasive alternative treatment of MC in children.

Cited by 24 publications

References 9 publications

Efficacy and Side Effects of Topical Applications of Two Different Solutions in the Treatment of Molluscum Contagiosum in a City in Africa: An Open, Randomized, Comparative Clinical Trial

Efficacy and Side Effects of Topical Applications of Two Different Solutions in the Treatment of Molluscum Contagiosum in a City in Africa: An Open, Randomized, Comparative Clinical Trial

Comparison of 10% potassium hydroxide solution versus cryotherapy in the treatment of molluscum contagiosum: An open randomized clinical trial

Interventions for cutaneous molluscum contagiosum

Contact Info

Product

Resources

About