Treatment of pemphigus and linear IgA dermatosis with nicotinamide and tetracycline: A review of 13 cases

Chaffins, Marsha; Collison, Daniel W.; Fivenson, David P.

doi:10.1016/s0190-9622(08)80651-2

Cited by 155 publications

(71 citation statements)

References 15 publications

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“…nicotinic acetylcholine receptor agonist choline (51)(52)(53) and inhibition of the acetylcholine hydrolyzing enzyme acetylcholinesterase (54,55) Used to treat PV patients both systemically and topically (35), producing steroid-sparing effects; usually combined with either tetracycline (32)(33)(34)56) or minocycline (57)…”

Section: ␣7mentioning

confidence: 99%

Mechanisms of Mitochondrial Damage in Keratinocytes by Pemphigus Vulgaris Antibodies

Kalantari-Dehaghi

Chen²,

Deng³

et al. 2013

Journal of Biological Chemistry

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Background: Previous studies suggested that mitochondrial antibodies contribute to pemphigus vulgaris (PV). Results: PV sera elicited mitochondrial damage, and mitochondria-protecting drugs exhibited protective effect in cell culture and mouse skin. Conclusion: PV antibodies altered O 2 respiration, disrupted electron transfer chain, and increased reactive oxygen species. Significance: Results provide the mechanism of therapeutic action and justify the use of mitochondria-protecting drugs in PV.

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Section: ␣7mentioning

confidence: 99%

Mechanisms of Mitochondrial Damage in Keratinocytes by Pemphigus Vulgaris Antibodies

Kalantari-Dehaghi

Chen²,

Deng³

et al. 2013

Journal of Biological Chemistry

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“…This combination possesses numerous anti-inflammatory and immunomodulatory properties 5,11,16,28,30,34,36) . Tetracycline and niacinamide have also been used in a wide variety of dermatoses in humans, including SP 6,11,30) . Anecdotal veterinary literature indicates that TCN is effective for the treatment of 25% of the cases of canine SP 5,8,28,34) .…”

Section: Introductionmentioning

confidence: 99%

Efficacy of Tetracycline and Niacinamide for the Treatment of Superficial Pemphigus (Pemphigus Foliaceus, Pemphigus Erythematosus) in 34 Dogs (1995-2010)

et al. 2011

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Thirty-four dogs with superficial pemphigus (pemphigus foliaceus, pemphigus erythematosus) were treated with tetracycline and niacinamide (TCN). Follow-up information was available for 29 dogs and 62% of those responded satisfactorily to TCN. Success or failure of TCN treatment was not associated with patient sex, duration of disease prior to treatment, previous systemic glucocorticoid therapy, the presence or absence of pruritus, duration of TCN administration, TCN dosage, ability to reduce the frequency of administration of TCN, or distribution of skin lesions.

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“…30 The mean maintenance dose of dapsone required to sustain a clinical response has been reported to be approximately 100mg daily. 31 One of the most common and almost invariable adverse effects of dapsone is hemolytic anemia. This usually occurs in patients with glucose-6-phosphate dehydrogenase (G-6-PD) deficiency.…”

Section: Dapsonementioning

confidence: 99%

“…Another short-term adverse effect of dapsone that can be potentially fatal is the 'sulfone syndrome'. 31 This syndrome is a hypersensitivity reaction to dapsone, characterized by druginduced hepatitis, fever, and rash occurring within 2 months of starting the drug. Other adverse effects such as methemoglobinemia, agranulocytosis, and neuropathies can also occur.…”

Section: Dapsonementioning

confidence: 99%

Pemphigus Vulgaris: An Insight on Conventional and Emerging Treatment Modalities

Hasan¹,

Khan²,

Sherwani³

et al. 2013

Int. Res. J. Pharm.

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According to Sir William Osler, Mouth is the mirror of the body which reflects systemic diseases. The oral mucosa may be affected by a variety of mucocutaneous diseases and oral lesions may occur first or very early in several muco-cutaneous disorders. Pemphigus is a group of potentially life threatening, chronic auto immune disorder characterized by epithelial blistering affecting muco-cutaneous surfaces. Autoantibodies in pemphigus vulgaris are directed against desmoglein in epithelial desmosomes, and the immune deposits result in intra-epithelial splitting (acantholysis). Oral lesions in the form of blisters and erosions are the first to manifest, and diagnosis is made by positive nikolsky's sign, coupled with characterstic histopathology and immunofluorescent features. Corticosteroids form the mainline of treatment, but adjuvant and newer therapies are also been used at an increasing rates. This article deals about the etiopathogenesis, clinical characterstics, diagnosis and treatment strategies for pemphigus vulgaris.

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Treatment of pemphigus and linear IgA dermatosis with nicotinamide and tetracycline: A review of 13 cases

Cited by 155 publications

References 15 publications

Mechanisms of Mitochondrial Damage in Keratinocytes by Pemphigus Vulgaris Antibodies

Mechanisms of Mitochondrial Damage in Keratinocytes by Pemphigus Vulgaris Antibodies

Efficacy of Tetracycline and Niacinamide for the Treatment of Superficial Pemphigus (Pemphigus Foliaceus, Pemphigus Erythematosus) in 34 Dogs (1995-2010)

Pemphigus Vulgaris: An Insight on Conventional and Emerging Treatment Modalities

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