Treatment of Periodontal Disease Significantly Affects the Rate of Cardiovascular Events in Patients With Chronic Kidney Disease

Gowdak, Luís Henrique Wolff; Santos‐Paul, Marcela Alves dos; Neves, Ricardo Simões; Paula, Flavio de; Bortolotto, Luiz; César, Luiz Antonio Machado; Ramires, José Antônio Franchini; David‐Neto, Elias; Lima, José Antônio Moreira

doi:10.1016/s0735-1097(19)30776-4

Cited by 2 publications

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“…Therefore, it is difficult to clarify the direct link between periodontitis and CKD outcomes. Nevertheless, a recent study showed that the risk of developing CVDs over 24 months was lower in patients with CKD treated with periodontal disease, which suggests an important role of periodontitis in cardiovascular outcomes of patients with CKD [16].…”

Section: Discussionmentioning

confidence: 99%

“…This was a retrospective cohort study including adolescent and adult patients aged 16 [9]), lipid profile, calcium, and phosphate, among others) were obtained from the electronic medical records system. Panoramic X-ray was performed for pre-KT dental examination and analyzed retrospectively by two periodontists for periodontal grading according to the new classification of periodontal diseases developed in 2017 by Tonetti et al [10].…”

Section: Study Design and Patientsmentioning

confidence: 99%

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The effect of periodontitis on recipient outcomes after kidney transplantation

Min

Park

Yang

et al. 2022

Kidney Res Clin Pract

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Background: Recent several reports have demonstrated that periodontitis is prevalent and adversely affects the survival in patients with chronic kidney disease (CKD) or end-stage kidney disease. However, its impact on transplant outcomes remains uncertain.Methods: This retrospective cohort study included 136 and 167 patients, respectively, who underwent living donor kidney transplantation (KT) at Seoul National University Hospital from July 2012 to August 2016 and Korea University Hospital from April 2008 to October 2018. We divided patients into three groups according to stages of periodontitis based on a new classification system. Results: Patients with severe periodontitis were older, had a higher prevalence of diabetes, a higher body mass index and C-reactive protein level, a lower cardiac output, and were more likely to be smokers, indicating its association with chronic systemic inflammation. After KT, stage IV periodontitis was independently associated with a lower incidence of acute T cell-mediated rejection, suggesting the possible effect of periodontitis on immune function. However, 1-year and 3-year estimated glomerular filtration rates were not different. Among the KT recipients followed up more than 3 years, new-onset cardiovascular disease occurred in nine patients, and coronary artery disease occurred more frequently in patients with stage IV periodontitis. However, diabetes was the independent predictor of new-onset coronary artery disease in multivariate logistic regression analysis.Conclusion: Our findings showed that periodontitis might be an important player in determining posttransplant outcomes in recipients. Further interventional trials to test whether treating periodontitis could modify transplant outcome are needed.

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Section: Discussionmentioning

confidence: 99%

Section: Study Design and Patientsmentioning

confidence: 99%

The effect of periodontitis on recipient outcomes after kidney transplantation

Min

Park

Yang

et al. 2022

Kidney Res Clin Pract

View full text Add to dashboard Cite

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Associative Parallels, Interrelations and Interdependencies Between Clinical Features of Dental Pathology and Cardiovascular Diseases

Galonsky

Surdo

Chernov³

et al. 2021

Actual Problems in Dentistry

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Subject. Diseases of the cardiovascular system are characterised by oral cavity manifestations which possible has inverse relationships. Prevalence and features of hard oral tissues, mucosa of the oral cavity and periodontium in cardiovascular patients is investigated. Aim — to form a list of main trends and scientific practical prospects related to cardiovascular diseases and dental pathology. Methods. In order to perform analysis of the studied topic, a review of 30 periodicals dated 2007-2019 was performed. Results. The analysis of Russian and foreign scientific literature resulted in formulation of three main groups of dental diseases with peculiarities in manifestations if IHD and HD: 1. Diseases of hard oral tissues; 2. Diseases of the mucous coat of the oral cavity; 3. Periodontium tissue diseases. Examination of oral cavity hygienic condition in CVD patients showed worse values in comparison with the control group. A major emphasis is placed on the role of C-reactive protein and the role of systemic inflammation in dental and cardiovascular pathology. Also, there is data regarding treatment of periodontium tissues and its influence on the cardiovascular system. Inverse interaction was noted: intake of medicines against the main pathology exerted influence on the oral cavity condition. Conclusion. The performed review of Russian and foreign literature makes it possible to conclude that the data presented is insufficient to draw any firm conclusion. Of principal interest are periodontium tissue diseases and their correlation with general somatic pathology, indicative of which is a significant number of practical researches devoted to this issue. However, the data analysed are of controversial character and do not make it possible to form a single trajectory for management of such patients and assessment of not only dental but also general somatic status of the patient.

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Treatment of Periodontal Disease Significantly Affects the Rate of Cardiovascular Events in Patients With Chronic Kidney Disease

Cited by 2 publications

References 0 publications

The effect of periodontitis on recipient outcomes after kidney transplantation

The effect of periodontitis on recipient outcomes after kidney transplantation

Associative Parallels, Interrelations and Interdependencies Between Clinical Features of Dental Pathology and Cardiovascular Diseases

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