Treatment of periodontal intrabony defects using autologous platelet‐rich fibrin and titanium platelet‐rich fibrin: a randomized, clinical, comparative study

Abstract

The present study demonstrated that marked improvements in the clinical parameters and radiographic outcomes were noted with both autologous PRF and TPRF in the treatment of IBD.

Evaluation of titanium-prepared platelet-rich fibrin and leucocyteplatelet-rich fibrin in the treatment of intra-bony defects: Arandomized clinical trial

“…In the present study, the intra-group comparison revealed a significant original defect fill in both the T-PRF and L-PRF groups. In contrast, inter-group comparisons significantly favored the T-PRF group, which is quite different from the results reported by Chatterjee et al, 19 who found a higher percentage of defect fill for T-PRF with no significant difference. Moreover, the results of inter-group comparisons concerning original defect fill are different from the results reported by Mitra et al, 29 who showed no significant difference between the T-PRF and L-PRF groups.…”

“…30 In the present study, intra-group comparisons showed a significant decrease in PPD from baseline to 9 months in both the T-PRF and L-PRF groups, whereas inter-group comparisons revealed nonsignificant differences. This was consistent with Chatterjee et al, 19 Sharma and Pradeep 8 , and Patel et al 31 However, the mean reduction in PPD values of the L-PRF group in the present study was higher than that in a study by Patel et al, 31 where the followup period was one year. Thus, PRF (both T-PRF and L-PRF) serves as a reservoir for growth factors and cytokines, which decrease the levels of matrix metalloproteinase-8 and interleukin-1β and increase tissue inhibitors of matrix metalloproteinase-1 levels, resulting in periodontal soft tissue healing.…”

“…In the present study, a significant mean CAL gain was noted from baseline to 9 months in both groups in intra-group comparisons, consistent with Chatterjee et al, 19 and Mitra et al 29 This gain in CAL reflects proper wound healing in the presence of T-PRF and L-PRF. Thus, CAL is considered as an endpoint of regenerative attempts around natural dentition in regenerative studies.…”

“…However, inter-group comparisons revealed a non-significant result, indicating that the change was the same in both T-PRF and L-PRF groups. This is consistent with Chatterjee et al, 19 Chacko et al, 28 and Mitra, DK et al, 29 who showed a significant decrease in PI and GI values during a 9-month follow-up period for intra-group comparisons and a non-significant reduction in inter-group comparisons. This can be interpreted as useful; repeated removal of plaque biofilm as well as oral hygiene maintenance by the patients contributed to a proper environment for healing and decreasing gingival inflammation.…”

“…For accurate measurements, acrylic stents with grooves were customized for every patient. 19 Intra-examiner calibration was achieved when 10 patients’ measurements were assessed 24 hours apart before the initiation of the study. Calibration was taken into account only when the values at baseline and 24 hours were similar up to ±1 mm at 90% level.…”